Fig. 1
Fig. 2
Fig. 3
Fig. 4
Dose-response parameters (arithmetic mean with 90% confidence interval), based on the tension, frequency and amplitude of contractions in immature pigs, cyclic pigs on days 12–14 of the estrous cycle and early pregnant pigs on days 12–16 of pregnancy treated with concentrations of bisphenol A and F increasing from 10−13 to 10−1 M
| Parameters | Tension | Amplitude | Frequency | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Immature | Cyclic | Pregnant | Immature | Cyclic | Pregnant | Immature | Cyclic | Pregnant | |
| BPA 8.887 (8.433–9.341) | 6.451 (6.201–6.700) | 16.73 (15.64–17.81) | 24.82 (23.34–26.30) | 23.09 (22.21–23.97) | 27.20 (25.66–28.73) | 12.74 (11.17–14.31) | 6.037 (5.713–6.360) | 8.235 (6.842–9.629) | |
| Emax | 8.340 BPF (7.948–8.731) | 10.03 (9.776–10.29) | 8.386 (7.657–9.114) | 22.00 (21.45–22.56) | 28.77 (28.23–29.31) | 23.68 (21.24–26.13) | 9.702 (8.885–10.52) | 5.055 (4.808–5.302) | 4.978 (4.687–5.270) |
| 5.966 BPA (5.071–6.861) | 4.321 (2.913–5.728) | 10.09 (7.973–12.21) | 10.98 (8.672–13.28) | 12.11 (10.95–13.27) | 21.56 (21.01–22.11) | 4.188 (3.280–5.096) | 2.676 (2.122–3.229) | 4.325 (3.958–4.692) | |
| E0 | BPF 6.756 (6.561–6.950) | 8.619 (8.504–8.735) | 2.383 (0.1448–4.622) | −0.07270 (−0.4302–0.2848) | −1.726 (−2.557−0.8954) | 10.30 (8.076–12.53) | 0.1706 (−0.2099–0.5510) | 0.9818 (0.8362–1.127) | −0.7278 (−1.361−0.09438) |
| Span | BPA 2.921 (1.937–3.905) | 2.130 (0.7245–3.536) | 6.632 (4.296–8.968) | 13.84 (11.24–16.45) | 10.98 (9.603–12.36) | 5.635 (4.026–7.245) | 8.554 (6.768–10.34) | 3.361 (2.752–3.970) | 3.910 (2.478–5.342) |
| BPF 1.584 (1.153–2.015) | 1.415 (1.135–1.695) | 6.002 (3.812–8.192) | 22.08 (21.44–22.72) | 30.50 (29.55–31.44) | 13.38 (10.15–16.61) | 9.531 (8.639–10.42) | 4.073 (3.791–4.355) | 5.706 (5.052–6.360) | |
| −3.775 BPA (−4.633−2.916) | −1.758 (−2.769−0.7461) | −3.807 (−4.703−2.911) | −2.192 (−2.608−1.776) | −2.477 (−2.793−2.161) | −10.17 (−10.87−9.477) | −5.665 (−6.325−5.004) | −2.061 (−2.441−1.681) | −10.11 (−11.01−9.210) | |
| LogIC50 | −6.622 BPF (−7.489−5.755) | −7.314 (−7.925−6.703) | −1.634 (−2.302−0.9650) | −4.799 (−5.226−4.372) | −2.225 (−2.294−2.155) | −5.113 (−5.772−4.453) | −7.070 (−7.351−6.789) | −7.292 (−7.497−7.087) | −1.830 (−2.057−1.604) |
| BPA 1.554 | −11.34 | 24.19 | 9.012 | −5.332 | −11.53 | 1.141 | −30.13 | −18.68 | |
| AIC | BPF −37.77 | −50.61 | −8.395 | −19.02 | −17.05 | 14.35 | −19.84 | −46.59 | −32.40 |
| BPA 0.6702 | 0.4082 | 1.601 | 0.8928 | 0.5143 | 0.3188 | 0.6596 | 0.1981 | 0.3078 | |
| RMSE | BPF 0.1477 | 0.09013 | 0.4571 | 0.2268 | 0.3277 | 1.072 | 0.2943 | 0.08467 | 0.1816 |