Effects of vitamin C and magnesium L-threonate treatment on learning and memory in lead-poisoned mice Cover

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Effects of vitamin C and magnesium L-threonate treatment on learning and memory in lead-poisoned mice

Journal of Veterinary Research

Volume 65 (2021): Issue 2 (June 2021)

By: Kemajl Bislimi, Ilir Mazreku, Jeton Halili, Valbona Aliko, Kushtrim Sinani and Liridon Hoxha

Open Access

|Jun 2021

Figures & Tables

Latency or time from the start of the trial to the platform entry. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C– vitamin C; MgT – magnesium L-threonate

Latency to first entry into the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day)
Vit C – vitamin C; MgT – magnesium L-threonate — Latency to first entry into the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate

Number of entries in the platform zone (line crossing). Data were calculated as the mean of blocks of trials (nine trials per day)
Vit C – vitamin C; MgT – magnesium L-threonate — Number of entries in the platform zone (line crossing). Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate

Time in the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C – vitamin C; MgT – magnesium L-threonate

Catalase activity level (CAT IU/ mg protein) in Swiss albino mouse liver, kidney, pancreas and brain tissue after administration of lead acetate

Group
		Control (n = 10)	Pb (n = 10)	Pb+Vit C (n = 10)	Pb+MgT (n = 10)	MgT (n = 10)
Organ	Liver	222.5 ± 45.61	501.8 ± 70.10*	229.3 ± 54.13	250.2 ± 81.52	204.9 ± 50.02
	Pancreas	18.5 ± 8.98	51.2 ± 16.12*	31.3 ± 17.54	26.3 ± 13.22	37.3 ± 16.75
	Kidney	97.3 ± 34.56	269.1 ± 55.89**	124.6 ± 43.54	105.3 ± 52.23	130.5 ± 42.54
	Brain	3.9 ± 2.86	8.1 ± 3.05*	9.3 ± 3.67*	8.9 ± 3.11*	4.4 ± 2.26

Lead concentration (mg/kg) in the brains of mice treated with different combinations of chemicals

Group
Parameter	Control (n = 10)	Pb (n = 10)	Pb+Vit C (n = 10)	Pb+MgT (n = 10)	MgT (n = 10)
Pb	0.35 ± 0.001	1.58 ± 0.009*	1.67 ± 0.039*	0.94 ± 0.035*	0.41 ± 0.025

Average values of body weight and food and water intake during the 40 days of treatment

Group	Initial average body weight (g)	Terminal average body weight (g)	Average daily food intake (g)	Average daily water intake (mL)
Control	35.24	35.05	6.89	6.21
Pb	33.34	36.97	7.01	6.07
Pb+Vit C	32.24	35.69	6.51	6.11
Pb+MgT	33.52	35.91	6.78	6.15
MgT	34.04	37.12	7.12	6.52

Average organs weights in grams (liver, kidney, pancreas and brain) of mice (Mus musculus Swiss albino) after dissection

Group
		Control (n = 10)	Pb (n = 10)	Pb+Vit C (n = 10)	Pb+MgT (n = 10)	MgT (n = 10)
Organ	Liver	1.02 ± 0.29	0.89 ± 0.08	0.93 ± 0.16	0.92 ± 0.49	1.11 ± 0.26
	Pancreas	0.20 ± 0.10	0.17 ± 0.07	0.23 ± 0.07	0.15 ± 0.10	0.17 ± 0.05
	Kidney	0.38 ± 0.16	0.50 ± 0.08	0.56 ± 0.12	0.55 ± 0.10	0.43 ± 0.10
	Brain	0.35 ± 0.03	0.36 ± 0.05	0.35 ± 0.02	0.36 ± 0.02	0.36 ± 0.04

DOI: https://doi.org/10.2478/jvetres-2021-0032 | Journal eISSN: 2450-8608

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Language: English

Page range: 217 - 223

Submitted on: Nov 27, 2020

Accepted on: May 21, 2021

Published on: Jun 8, 2021

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Related subjects:

Molecular biology,

Microbiology and virology,

Life sciences, other,

Veterinary medicine

© 2021 Kemajl Bislimi, Ilir Mazreku, Jeton Halili, Valbona Aliko, Kushtrim Sinani, Liridon Hoxha, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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