Evaluation of oxidative stress parameters in dogs with brachycephalic obstructive airway syndrome before and after surgery

	Control	Grade 1	Grade 2	Grade 3
Number	9	5	16	13
Sex (female/male)	4/5	3/2	5/11	6/7
Age (years) Median; IQR	3.25; 1.84–3.96	3.75; 1.08–6.96	2.88; 1.14–7.11	1.75; 1.46–8.88
Weight (kg) Median; IQR	9.50; 8.45–11.25	9.56; 5.75–11.54	10.20; 7.78–12.53	9.60; 8.37–10.70
BCS Median; IQR	3.0; 3.0–3.5	3.0; 2.5–3.5	3.0; 3.0–4.0	3.0; 3.0–3.0

[i] BCS – body condition score; IQR – interquartile range (25th to 75th percentile)

Table 2

Clinical signs (mean) in groups of brachycephalic obstructive airway syndrome patients before and after surgery

	Respiratory signs	Gastrointestinal signs	Exercise intolerance	Sleep disorders
Grade 1
Before surgery	3.1	1.8	2.1	3.7
After surgery	1.5a	1.2	1.0	2.0a
Grade 2
Before surgery	3.2	2.3	1.8	4.1
After surgery	1.8a	1.6a	1.5	2.4a
Grade 3
Before surgery	3.1	2.1	1.8	3.8
After surgery	1.9a	1.4a	1.2a	2.7a

a Significant (P < 0.05) difference in comparison to values before surgery 1.0 means that the clinical sign was not present and 5.0 means that the clinical sign was always present

Table 3

Oxidative stress parameters (mean ± standard deviation) in groups of brachycephalic obstructive airway syndrome patients before and after surgery and in the control group

	SOD (U/g Hgb)	GPX (U/g Hgb)	MDA (μmol/L)
Grade 1
Before surgery	1821.1 ± 155.9a	451.7 ± 41.3	6.06 ± 1.80
After surgery	1816.5 ± 116.1	460.0 ± 49.9	6.37 ± 1.11
Grade 2
Before surgery	1554.4 ± 200.1	454.3 ± 83.1	6.68 ± 1.02
After surgery	1593.7 ± 207.4b	466.0 ± 76.7	6.49 ± 0.89
Grade 3
Before surgery	1543.1 ± 222.3	508.2 ± 97.6	6.53 ± 1.62
After surgery	1683.2 ± 222.8b	504.8 ± 80.8	6.22 ± 1.12
Control	1625.1 ± 280.4	501.7 ± 73.5	6.92 ± 0.97

SOD – superoxide dismutase; GPX – glutathione peroxidase MDA – malondialdehyde; U/g Hgb – units per gram of haemoglobin

a significant (P < 0.05) difference in comparison to activity determined in grade 2 and 3 groups before surgery

b significant (P < 0.05) difference in comparison to activity before surgery

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DOI: https://doi.org/10.2478/jvetres-2021-0027 | Journal eISSN: 2450-8608 (formerly 2300-3235)

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Language: English

Page range: 201 - 208

Submitted on: Sep 30, 2020

Accepted on: May 7, 2021

Published on: May 22, 2021

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Keywords:

brachycephalic obstructive airway syndrome,

malondialdehyde,

superoxide dismutase,

glutathione peroxidase,

oral surgery

Related subjects:

Life sciences,

Molecular biology,

Microbiology and virology,

Life sciences, other,

Medicine,

Veterinary medicine

© 2021 Vladimira Erjavec, Tomaž Vovk, Alenka Nemec Svete, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 65 (2021): Issue 2 (June 2021)