Fig.1

Fig. 2

First collection of mammary secretion (time 0) from cows in experimental in vivo tests
| Tested product | Patient | Predominant bacterial species isolated from milk sample | CFU/mL | SCC/mL |
|---|---|---|---|---|
| Group 1 treated with R4 | 1. | S. epidermidis | 902,000 | 169,800 |
| 2. | S. epidermidis | 385,000 | 1,000,000 | |
| 3. | S. Micrococcus schleiferi, spp. | 89,000 | 114,300 | |
| 4. | S. Micrococcus schleiferi, spp. | 49,000 | 190,800 | |
| 5. | S. epidermidis | 172,000 | 3,600 | |
| 6. | S. epidermidis | 312,000 | 51,900 | |
| 7. | S. epidermidis | 171,600 | 195,800 | |
| 8. | S. epidermidis | 364,000 | 240,000 | |
| Group 2 treated with R7 | 9. | S. epidermidis | 66,000 | 102,100 |
| 10. | S. epidermidis | 334,000 | 80,300 | |
| 11. | S. epidermidis, S. hominis | 125,000 | 39,000 | |
| 12. | S. epidermidis | 41,000 | 54,000 | |
| 13. | Bacillus spp. | 48,000 | 105,900 | |
| 14. | S. epidermidis | 37,000 | 10 000 | |
| 15. | S. aureus | 177,000 | 129,000 | |
| 16. | Streptococcus spp. | 247,900 | 1,000,000 | |
| Control group treated with antibiotics | 17. | Bacillus spp. | 223,000 | 10,000 |
| 18. | S. Aerococcus aureus, spp. | 525,000 | 1,004,600 | |
| 19. | S. aureus | 218,000 | 12,000 | |
| 20. | Corynebacterium spp. Staphylococcus spp. Micrococcus spp. | 220,000 | 88,900 |
Pathogens identified in normal and mastitic milk
| Identified microorganism | Gram +/− | Kit type | Code profile |
|---|---|---|---|
| Staphylococcus epidermidis | + | API Staph | 6 7 7 3 1 5 1 |
| Staphylococcus aureus | + | API Staph | ATCC 6538P |
| Staphylococcus schleiferi | + | API Staph | 6 7 3 2 5 5 3 |
| Staphylococcus hominis | + | API Staph | 6 7 3 2 1 1 2 |
| Aerococcus viridans | + | VITEK Identification | 0625703821500211 |
| Aerococcus viridans | + | VITEK Identification | 0625707930700413 |
| Staphylococcus aureus | + | VITEK Identification | 0209610546712053 |
| Bacillus cereus | + | API 50 CHB | 7212 |
| Corynebacterium spp. | + | VITEK Identification | 4407611554521210 |
| Micrococcus spp. | + | VITEK Identification | 0625703050500211 |
| Streptococcus agalactiae | + | VITEK Identification | 0205610554226611 |