Study of troponin, creatine kinase biomarkers, and histopathological lesions in experimental Nerium oleander toxicity in rats and mice

Figures & Tables

Experimental groups		First day	Second day	Third day	Fourth day
10 mg/kg	BALB/C	177.5 ± 34.7^a Different letters in the same column show significant differences between mice and rats (P < 0.05)	171.7 ± 36.7^c	175.8 ± 31.4^e	164.3 ± 32.1^g
10 mg/kg	Rat	1176 ± 89.4^b	886 ± 82.4^d	961 ± 78.1^f	615.8 ± 61.9^h

12.5 mg/kg	BALB/C	219.7 ± 38.4^a	207.9 ± 35.8^c	204.9 ± 33.1^e	171.7 ± 35.9^g
12.5 mg/kg	Rat	965 ± 81.6^b	966 ± 78.3^d	934 ± 85.2^f	733.5 ± 82.2^h

15 mg/kg	BALB/^c	187.3 ± 32.8^a	206.4 ± 34.2^c	281.6 ± 24.2^e	173.5 ± 33.6^g
15 mg/kg	Rat	815 ± 88.4^b	952 ± 72.6^d	879 ± 79.6^f	586.8 ± 69.4^h

20 mg/kg	BALB/C	217.8 ± 35.8^a	237.5 ± 32.8^c	231.4 ± 3.8^e	169.4 ± 34.8^g
20 mg/kg	Rat	973 ± 79.7^b	986 ± 81.7^d	981 ± 81.8^f	694.7 ± 71.2^h

control	BALB/^c	155.6 ± 9.4^a	158.91 ± 10.3^c	160.0 ± 11.9^e	138.3 ± 3.8^g
control	Rat	183.7 ± 11.6^b	186.42 ± 12.3^d	185.75 ± 13.6^f	144.1 ± 11.4^h

Experimental groups		First day	Second day	Third day	Fourth day
10 mg/kg	BALB/C	183.3 ± 31.4^a Different letters in the same column show significant differences between mice and rats (P < 0.05)	164.3 ± 32.1^c	171.7 ± 39.3^e	239.7 ± 38.5^g
10 mg/kg	Rat	586.4 ± 69.2^b	615.8 ± 61.9^d	607.4 ± 54.6^f	719.6 ± 92.3^h

12.5 mg/kg	BALB/C	192.4 ± 34.3^a	171.7 ± 35.9^c	188.4 ± 35.6^e	214.6 ± 41.2^g
12.5 mg/kg	Rat	609.8 ± 71.7^b	733.5 ± 82.2^d	664.7 ± 72.3^f	687.8 ± 85.1^h

15 mg/kg	BALB/C	251.2 ± 41.9^a	173.5 ± 33.6^c	207.1 ± 38.7^e	237.2 ± 39.1^g
15 mg/kg	Rat	598.9 ± 75.8^b	586.8 ± 69.4^d	654.3 ± 75.8^f	723.4 ± 78.2^h

20 mg/kg	BALB/C	234.8 ± 39.2^a	169.4 ± 34.8^c	211.4 ± 36.5^e	266.7 ± 30.9^g
20 mg/kg	Rat	643.6 ± 72.3^b	694.7 ± 71.2^d	677.8 ± 76.9^f	768.7 ± 89.4^h

control	BALB/C	37.3 ± 3.4^a	38.3 ± 3.8^c	38.0 ± 3.2^e	38.0 ± 3.6^g
control	Rat	42.9 ± 10.1^b	44.1 ± 11.4^d	43.7 ± 10.8^f	45.2 ± 12.7^h