Estimation of body composition and water data depends on the bioelectrical impedance device

Bellafronte, Natália T.; Batistuti, Marina R.; dos Santos, Nathália Z.; Holland, Héric; Romão, Elen A.; G. Chiarello, Paula

doi:10.2478/joeb-2018-0014

Figures & Tables

Regression analyze between BIS and SFBIA bias (BIS-SFBIA) with BMI. Data analyzed only for BMI subgroups. BIS, multifrequency bioelectrical impedance spectroscopy; BMI, body mass index; ECW, extracellular water; FFM, fat free mass; FM, fat mass; ICW, intracellular water; PA, phase angle; R, resistance; SFBIA, single-frequency bioelectrical impedance; TBW, total body water; Xc, reactance. (a) R; (b) Xc; (c) PA; (d) TBW; (e) ICW; (f) ECW; (g) FFM; (h) FM. Circle: underweight; Square: normal weight; Trapezium: overweight; Triangle: obese.

Regression analyze between BIS and SFBIA bias (BIS-SFBIA) with OH. Data analyzed only for CKD groups. BIS, multifrequency bioelectrical impedance spectroscopy; BMI, body mass index; CKD, chronic kidney disease; ECW, extracellular water; FFM, fat free mass; FM, fat mass; ICW, intracellular water; PA, phase angle; R, resistance; SFBIA, single-frequency bioelectrical impedance; TBW, total body water; OH, overhydration state; Xc, reactance. (a) R; (b) Xc; (c) PA; (d) TBW; (e) ICW; (f) ECW; (g) FFM; (h) FM.

Descriptive data for non-CKD subjects stratified in BMI subgroups and for CKD patients stratified in PD and HD subgroups

	BMI<18.5	18.5≤BMI<25	25≤BMI<30	BMI≥30	PD	HD
n	40	120	118	108	30	93
Women (%)	32	62	59	52	11	42
	(80)	(51)	(50)	(48)	(37)	(45)
Age (years)	26±4.2^a	29±3.9^a	29±4.6^a	30±5^a	52±19^b	47±13^c
	(20 to 38)	(20 to 40)	(20 to 40)	(20 to 40)	(15 to 81)	(20 to 76)
Weight (kg)	48±4.9^a	64±9.4^b	79±9.8^c	98±12^d	68±13^be	72±17^e
	(39 to 60)	(45 to 87)	(59 to 109)	(71 to 124)	(38 to 93)	(42 to 137)
BMI (kg/m²)	18±0.7^a	22±1.8^b	27±1.4^c	34±2.7^d	24±3.4^e	26±5^e
	(15 to 18)	(19 to 25)	(25 to 30)	(30 to 40)	(16 to 32)	(17 to 44)
OH (L)	-0.1±0.4^a	-0.3±0.7^a	-0.5±0.9^ab	-0.8±0.9^b	2.1±2.2^c	-0.9±1.9^b
	(-1.2 to 0.9)	(-1.9 to 1.5)	(-3.1 to 2.1)	(-3 to 1.8)	(-0.7 to 6.2)	(-5 to 6.0)
OH>1.1 L (%)	0	0	4	3	17	10
	(0)	(0)	(3)	(3)	(57)	(11)
OH<-1.1 L (%)	0	14	29	42	0	49
	(0)	(12)	(25)	(39)	(0)	(53)
FFM (kg)	34±6.3^a	43±11^b	45±13^b	46±13^b	34±6.6^a	38±9.7^a
	(26 to 51)	(26 to 70)	(27 to 76)	(25 to 76)	(24 to 56)	(20 to 60)
FFMI (kg/m²)	12±1.5^a	15±2.8^b	15±3.1^b	15±3.1^b	12±1.8^a	14±2.6^a
	(10 to 16)	(9 to 22)	(10 to 23)	(9 to 23)	(8 to 16)	(8 to 20)
FM (kg)	14±4^a	21±7.1^b	34±9.3^c	52±12^d	30±12^c	34±16^c
	(4 to 21)	(3 to 37)	(11 to 57)	(24 to 83)	(9 to 56)	(2 to 99)
FMI (kg/m²)	5±1.5^a	7±2.7^b	12±3.5^c	18±4.6^d	11±4.2^c	12±5.6^c
	(1 to 8)	(1 to 13)	(4 to 19)	(8 to 29)	(4 to 19)	(1 to 29)
PA (^ₒ)	5.8±0.5^a	6.6±0.8^b	6.8±0.8^b	6.8±0.8^b	4.7±1.1^c	6.1±1.2^a
	(4.8 to 7)	(4.8 to 8.2)	(5.3 to 9)	(5 to 8.9)	(2.8 to 7.1)	(3 to 9.1)
Impairment Nutritional status (%)¹	4	7	4	2	23	33
	(10)	(6)	(3)	(2)	(76)	(36)
DM (%)	0	0	0	0	10	61
	(0)	(0)	(0)	(0)	(33)	(66)
SAH (%)	0	0	0	0	19	61
	(0)	(0)	(0)	(0)	(63)	(66)
Residual Diuresis (ml)²					937±680***	170±330***
					(50 to 2000)	(0 to 2000)
Kt/V¹					2.6±0.9^***	1.5±0.3^***
					(1.4 to 4.5)	(1 to 2.5)
Duration of dialytic treatment					33±32^***	63±48^***
(months)²					(3 to 144)	(5 to 264)
Dialytic treatment >12 months (%)					21	82
					(70)	(88)

Statistics of BIS vs SFBIA data in CKD subjects (PD and HD subgroups)

PD subgroup (n=30)
						Bland-Altman
							95% limits of agreement
Data analysed	BIS	SFBIA	ICC	r	Bias^a (%)^b	95%CI Bias^c (%)^d	Lower	Upper
R (ohm)	533±83	532±83	0.03	0.04	1±115 (0.2±21)	42 to 44 (7.5 to 8)	-224	226
Xc (ohm)	44±15	48±14	-0.16	-0.2	-4±22 (-9±47)	-12 to 4.4 (-27 to 8.4)	-48	40
PA (^ₒ) TBW (L)	4.7±1.1 34±5.4	5.1±1 38±6.4	-0.23 0.59**	-0.2 0.75***	-0.5±1.6 (-10±34) -4.2±4.2 (-11±11)	-1.1 to 0.15 (-23 to 2.7) -5.7 to -2.6 (-16 to -7.4)	-3.7 -12	2.7 4.1
ECW (L)	17±3.3	19±3.2	0.47**	0.52**	-1.4±3.2 (-8.3±19)	-2.6 to -0.2 (-15 to -1.4)	-7.7	4.9
ICW (L)	17±2.7	20±3.9	0.40**	0.58**	-2.8±3.2 (-14±16)	-3.9 to -1.6 (-20 to -1.2)	-9	3.4
FFM (kg)	34±6.6	49±8.9	0.50**	0.79***	-15±8.3 (-36±17)	-18 to -12 (-43 to -30)	-31	1.3
FM (kg)	31±12	19±12	0.14*	0.44**	11±7.7 (95±257)	7.7 to 13 (1.0 to 191)	-4.5	26
HD subgroup (n=93)
					Bland-Altman
							95% limits of agreement
Data	BIS	SFBIA	ICC	r	Bias^a (%)^b	95%CI Bias^c (%)^d	Lower	Upper
analysed
R (ohm)	730±128	606±103	-0.03	-0.05	124±168 (18±25)	90 to 159 (13 to 23)	-206	454
Xc (ohm)	78±22	68±17	0.18*	0.16	10±25 (13±38)	5.2 to 16 (5.3 to 21)	-40	60
PA (^ₒ)	6.1±1.2	6.4±1.3	0.05	0.07	-0.3±1.7 (-5.3±29)	-0.7 to 0.1 (-11 to 0.6)	-3.7	3
TBW (L)	33±6.9	36±5.7	0.64**	0.71***	-2.6±5 (-8.5±14)	-3.7 to -1.6 (-11 to -5.6)	-12	7.1
ECW (L)	14±3.2	17±3.1	0.38**	0.51**	-2.6±3.1 (-18±19)	-3.3 to -2 (-21 to -14)	-8.8	3.5
ICW (L)	19±4.2	19±3.7	0.68**	0.68**	-0.01±3.2 (-0.7±17)	-0.7 to 0.6 (-4.1 to 2.8)	-6.3	6.2
FFM (kg)	38±9.7	49±7.9	0.65**	0.85***	-11±8.2 (-27±20)	-13 to -9.3 (-31 to -23)	-27	5.1
FM (kg)	34±16	23±13	0.32**	0.58**	11±8.2 (45±44)	9.5 to 13 (36 to 54)	-5	27

Statistics of BIS vs SFBIA data in non-CKD BMI stratified subgroup

Underweight subjects (n=40)
						Bland-Altman
							95% limits of agreement
Data analysed	BIS	SFBIA	ICC	r	Bias^a (%)^b	95%CI Bias^c (%)^d	Lower	Upper
R (ohm)	848±74	596±103	-0.02	-0.12	252+134 (35.5+18.9)	209 to 294 (29 to 42)	-10	513
Xc (ohm)	86±9.3	63±9.5	-0.03	-0.12	23+14 (31.1+18.1)	19 to 28 (25 to 37)	-4.6	51
PA (^ₒ)	5.8±0.5	6.1±0.6	0.12	0.09	-0.3+0.8 (-4.8+12.6)	-0.5 to -0.05 (-8.9 to -0.7)	-1.8	1.2
TBW (L)	27±3.9	30±4.1	0.38**	0.47**	-3.4+4.1 (-11.7+14.3)	-4.7 to -2 (-16 to -7.1)	-11	4.7
ECW (L)	11±1.4	14±2.2	0.20*	0.47**	-2.9+2 (-22.8+14.8)	-3.6 to -2.3 (-28 to -18)	-6.8	0.9
ICW (L)	16±2.6	16±1.9	0.45**	0.44**	-0.4+2.5 (-3.1+14.8)	-1.2 to 0.4 (-7.9 to 1.7)	-5.2	4.4
FFM (kg)	34±6.3	43±4.8	0.26*	0.59**	-9.1+5.1 (-24.4+13.9)	-11 to -7.5 (-29 to -20)	-19	1
FM (kg)	14±4	5±4.4	0.07*	0.27*	8.8+5.1 (81+202.4)	7.2 to 10 (15 to 147)	-1.1	19
Normal weight subjects (n=120)
						Bland-Altman
							95% limits of agreement
Data analysed	BIS	SFBIA	ICC	r	Bias^a (%)^b	95%CI Bias^c (%)^d	Lower	Upper
R (ohm)	718±99	621±97	-0.02	-0.05	97+141 (14.6+20.6)	71 to 122 (11 to 18)	-180	374
Xc (ohm)	82±9.6	63±8.9	0.04	0.13	19+12 (25.8+16.9)	16 to 21 (23 to 29)	-5.3	43
PA (^ₒ)	6.6±0.8	5.9±0.5	0.10	0.17	0.7+0.9 (11.1+14.1)	0.5 to 0.9 (8.6 to 14)	-1	2.5
TBW (L)	35±7.3	32±4.4	0.51**	0.62**	2.1+5.7 (4.9+16.7)	1.0 to 3.1 (1.8 to 7.9)	-9.1	13
ECW (L)	14±2.6	16±2.4	0.58**	0.66**	-1.3+2.1 (-9.4+14.3)	-1.7 to -0.9 (-12 to -6.8)	-5.4	2.7
ICW (L)	20±4.8	17±2	0.27*	0.56**	3.4+4 (16.2+19.4)	2.7 to 4.1 (13 to 20)	-4.4	11
FFM (kg)	43±11	47±5.6	0.52**	0.71***	-3.6+8.5 (-10.9+20)	-5.2 to -2.1 (-15 to -7.2)	-20	13
FM (kg)	21±7.1	18±6.5	0.21*	0.25*	3.6+8.3 (18.8+50.4)	2.1 to 5.1 (9.8 to 28)	-13	20
Overweight subjects (n=118)
						Bland-Altman
							95% limits of agreement
Data analysed	BIS	SFBIA	ICC	r	Bias^a (%)^b	95%CI Bias^c (%)^d	Lower	Upper
R (ohm)	650±78	547±102	0.01	0.02	102±128 (18±22)	79 to 126 (14 to 22)	-148	352
Xc (ohm)	77±9	62±8.3	0.01	-0.02	15±12 (21±18)	12 to 17 (18 to 24)	-9.6	39
PA (^ₒ)	6.8±0.8	6.6±0.9	0.01	0.01	0.2±1.2 (3±18)	-0.03 to 0.4 (-0.4 to 6.3)	-2.2	2.6
TBW (L)	38±7.7	37±6	0.52**	0.52**	0.8±6.8 (1.4±18)	-0.4 to 2.1 (-1.8 to 4.7)	-13	14
ECW (L)	16±2.8	17±2.8	0.65**	0.70***	-0.9±2.2 (-6.1±13)	-1.4 to -0.6 (-8.4 to -3.7)	-5.2	3.3
ICW (L)	22±5.1	20±3.5	0.30**	0.34**	1.8±5.1 (7.4±23)	0.9 to 2.8 (3.1 to 12)	-8.1	12
FFM (kg)	45±13	55±8.9	0.31**	0.46**	-9.5±12 (-21±24)	-12 to -7.4 (-26 to -17)	-32	13
FM (kg)	34±9.2	24±5.7	-0.07*	-0.13*	9.6±11 (31±41)	7.5 to 12 (24 to 39)	-13	32
Obese subjects (n=108)
						Bland-Altman
							95% limits of agreement
Data analysed	BIS	SFBIA	ICC	r	Bias^a (%)^b	95% CI Bias^c (%)^d	Lower	Upper
R (ohm)	596±77	482±53	0.07	0.19	114±85 (20.8+14.8)	98 to 130 (17.9 to 23.6)	-52	280
Xc (ohm)	71±9.3	61±6.9	-0.01	-0.01	9.8±12 (14.5+17.4)	8 to 12 (11.2 to 17.9)	-13	33
PA (^ₒ)	6.8±0.8	7.2±0.6	0.01	-0.05	-0.4±1 (-5.7+15.3)	-0.6 to -0.2 (-8.7 to -2.8)	-2.5	1.7
TBW (L)	42±8.2	42±5.4	0.70***	0.77***	-0.6±5.4 (-2.4+12.5)	-1.6 to 0.4 (-4.8 to 0.01)	-11	9.9
ECW (L)	18±3.1	19±2.9	0.79***	0.82***	-0.8±1.9 (-4.5+9.7)	-1.2 to -0.4 (-6.4 to -2.7)	-4.4	2.8
ICW (L)	24±5.3	23±2.4	0.53**	0.69**	0.2±4 (-0.9+16.6)	-0.5 to 1 (-4.1 to 2.3)	-7.6	8.1
FFM (kg)	46±12.9	64±8.1	0.26*	0.71***	-18±9.2 (-36.4+20.5)	-20 to -16 (-40.3 to -32.5)	-36	-0.5
FM (kg)	52±11.5	33±6.7	0.16*	0.61**	19±9.1 (43.3+18.7)	17.2 to 20.7 (39.7 to 46.9)	1	37

Estimation of body composition and water data depends on the bioelectrical impedance device

Figures & Tables

Figure 1

Figure 2

Descriptive data for non-CKD subjects stratified in BMI subgroups and for CKD patients stratified in PD and HD subgroups

Statistics of BIS vs SFBIA data in CKD subjects (PD and HD subgroups)

Statistics of BIS vs SFBIA data in non-CKD BMI stratified subgroup

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