The Value of Optical Coherence Tomography Parameters in Estimating Non-Critical Lesions in Patients with Acute Myocardial Infarction

	n	Min	Max	Mean	s.d.	FFR ≤ 0.8	s.d.	FFR > 0.8	s.d.	p value
FFR	151	0.41	0.98	0.81	0.10	0.72	0.07	0.88	0.04	<0.001
Age	151	36.00	81.00	60.41	10.42	61.00	10.19	59.97	10.63	0.55
OCT proximal area	151	2.83	20.56	8.84	3.04	8.45	2.95	9.13	3.09	0.17
OCT distal area	151	1.79	18.38	6.79	2.77	6.23	2.66	7.22	2.80	0.03
Average area	151	2.68	19.47	7.82	2.55	7.34	2.37	8.17	2.64	0.04
Lesion length	151	6.20	65.60	31.33	13.20	35.55	14.52	28.14	11.18	0.001
MLA	151	0.75	5.51	2.21	1.06	1.61	0.62	2.67	1.09	<0.001
%AS average reference		21.51	92.00	70.97	11.80	76.97	8.04	66.44	12.19	<0.001
Proximal reference diameter		1.90	5.11	3.27	0.57	1.25	0.28	1.59	0.36	<0.001
Distal reference diameter		1.51	4.84	2.86	0.58	2.76	0.56	2.98	0.58	0.02
Average reference diameter		1.84	4.97	3.08	0.50	3.00	0.48	3.17	0.51	0.03
Minimum diameter	151	0.84	2.53	1.44	0.37	1.25	0.28	1.59	0.36	<0.001
%Diameter stenosis (vs. average reference diameter)		26.18	83.69	46.78	10.19	50.35	10.17	42.05	8.15	<0.001
FFR ≤ 0.8		65	43%			65		86
Vessel	LAD	80	53.30%			47 (72.3%)		33 (38.4%)		<0.001
	RCA	38	25.30%
	LCX	33	21.85%
Male		127	84.10%			56 (86.2%)		71 (82.6%)		0.55
Smoker		46	30.50%			23 (35.4%)		23 (26.7%)		0.253
Hypertension		116	76.80%			45 (69.2%)		71 (82.6%)		0.055
Dyslipidemia		121	80310%			50 (76.9%)		71 (82.6%)		0.341
Diabetes mellitus		47	31.10%			20 (30.8%)		27 (31.4%)		0.93

OCT with 3D reconstruction. Severe malposition of the stent requiring 1:1 noncompliant balloon post dilatation.

ROC curve for OCT-derived MLA to predict FFR < 0.8. Sensibility 83.1%, specificity 68.6%, accuracy 74.8%.

AUC, Test result variable(s): MLA
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.810	0.035	0.000	0.741–0.879

AUC Test result variable(s): PAS
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.761	0.039	0.000	0.685–0.836

AUC Test result variable(s): MLA x
Area	Std. Error^a	P	Asymptotic 95% CI
0.835	0.045	0.000	0.747–0.922

Area under the ROC curve
Test result variable(s)	Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
%RMA	0.761	0.039	0.000	0.685–0.837
MLA x	0.810	0.035	0.000	0.741–0.879

Paired-sample area difference under the ROC curves
Test result pair(s)	Asymptotic	AUC difference		Std. error difference	Asymptotic 95% CI
RMA	-1.572	0.116	-0.049	0.269	-0.111–0.012
MLA x

ROC curve for PAS to predict FFR < 0.8. Sensibility 60.0%, specificity 80.2%, accuracy 71.5%.

AUC Test result variable(s): %PAS
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.752	0.055	0.000	0.644–0.861

AUC Test result variable(s): %AS average reference
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.926	0.052	0.000	0.823–1.000

AUC Test result variable(s): MLA x
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.916	0.046	0.000	0.826–1.000

AUC Test result variable(s): MLA x
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.866	0.069	0.004	0.731–1.000

AUC Test result variable(s): %AS average reference
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.823	0.094	0.010	0.638–1.000

ROC curve for MLA in the LAD. Sensibility 78.3%, specificity 75.8%, accuracy 77.2%.

ROC curve for PAS in the LAD. Sensibility 91.3%, specificity 51.5%, accuracy 74.7%.

ROC curve for MLA in the RCA. Sensibility 90.1%, specificity 77.8%, accuracy 81.6%.

ROC curve for PAS in the RCA. Sensibility 100.0%, specificity 33.3%, accuracy 52.6%.

ROC curve for MLA in the CX. Sensibility 100.0%, specificity 48.0%, accuracy 59.4%.

ROC curve for PAS in the CX. Sensibility 85.7%, specificity 76.0%, accuracy 78.1%.

TABLE 2.

Univariate predictors for FFR ≤ 0.8

	B	p value	Exp(B) (95% CI)
LAD location	1.434	0.000	4.19 (2.09-8.41)
OCT proximal reference area	0.077	0.173	0.93 (0.83-1.03
OCT distal reference area	0.140	0.034	0.87 (0.76-0.99)
Average reference area	0.138	0.050	0.87 (0.76-1)
Lesion length	0.045	0.001	1.05 (1.02-1.07
MLA	1.538	0.000	0.21 (0.12-0.38)
PAS vs. RA	0.110	0.000	1.12 (1.07-1.17)
PAS vs. proximal reference	0.103	0.000	1.11 (1.06-1.16)
PAS vs. distal reference	0.071	0.000	1.07 (1.04-1.11)

TABLE 3.

Multivariate predictors for FFR ≤ 0.8

	B	Wald	p value	Exp(B) (95% CI)
MLA	-2.317	27.369	0.000	0.099 (0.041 - 0.235)
LAD location	2.345	20.161	0.000	10.434 (3.749 – 29.04)
Lesion length	0.045	6.361	0.012	1.046 (1.01 – 1.084)
OCT distal reference area	0.241	5.215	0.022	1.273 (1.035 – 1.566)

References

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Articles in this issue

DOI: https://doi.org/10.2478/jce-2026-0003 | Journal eISSN: 2457-5518 | Journal ISSN: 2457-550X

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Language: English

Page range: 29 - 37

Submitted on: Jan 26, 2025

Accepted on: Mar 2, 2026

Published on: Mar 27, 2026

Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

acute myocardial infarction,

optical coherence tomography,

fractional flow reserve,

minimal lumen area,

percent luminal stenosis area,

critical cut-off point

Related subjects:

Emergency medicine and intensive-care medicine,

Radiology

© 2026 Bogdan Dragoescu, Liviu Stan, Vlad Ploscaru, Lucian Calmac, Cosmin Mihai, Mugur Marinescu, Nicoleta Popa Fotea, Daniel Tonu, Alexandra Dumitru, Diana Stanciulescu, Alexandru Scafa-Udriste, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 12 (2026): Issue 1 (March 2026)

The Value of Optical Coherence Tomography Parameters in Estimating Non-Critical Lesions in Patients with Acute Myocardial Infarction

Figures & Tables

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TABLE 2.

TABLE 3.

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