The Value of Optical Coherence Tomography Parameters in Estimating Non-Critical Lesions in Patients with Acute Myocardial Infarction

Bogdan Dragoescu; Liviu Stan; Vlad Ploscaru; Lucian Calmac; Cosmin Mihai; Mugur Marinescu; Nicoleta Popa Fotea; Daniel Tonu; Alexandra Dumitru; Diana Stanciulescu; Alexandru Scafa-Udriste

doi:10.2478/jce-2026-0003

Figures & Tables

OCT with 3D reconstruction. Severe malposition of the stent requiring 1:1 noncompliant balloon post dilatation.

ROC curve for OCT-derived MLA to predict FFR < 0.8. Sensibility 83.1%, specificity 68.6%, accuracy 74.8%.

ROC curve for PAS to predict FFR < 0.8. Sensibility 60.0%, specificity 80.2%, accuracy 71.5%.

ROC curve for MLA in the LAD. Sensibility 78.3%, specificity 75.8%, accuracy 77.2%.

ROC curve for PAS in the LAD. Sensibility 91.3%, specificity 51.5%, accuracy 74.7%.

ROC curve for MLA in the RCA. Sensibility 90.1%, specificity 77.8%, accuracy 81.6%.

ROC curve for PAS in the RCA. Sensibility 100.0%, specificity 33.3%, accuracy 52.6%.

ROC curve for MLA in the CX. Sensibility 100.0%, specificity 48.0%, accuracy 59.4%.

ROC curve for PAS in the CX. Sensibility 85.7%, specificity 76.0%, accuracy 78.1%.

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AUCTest result variable(s): %AS average reference
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.823	0.094	0.010	0.638–1.000

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Paired-sample area difference under the ROC curves
Test result pair(s)	Asymptotic	AUC difference		Std. error difference	Asymptotic 95% CI
RMA	-1.572	0.116	-0.049	0.269	-0.111–0.012
MLA x

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Area under the ROC curve
Test result variable(s)	Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
%RMA	0.761	0.039	0.000	0.685–0.837
MLA x	0.810	0.035	0.000	0.741–0.879

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AUCTest result variable(s): %AS average reference
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.926	0.052	0.000	0.823–1.000

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AUCTest result variable(s): %PAS
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.752	0.055	0.000	0.644–0.861

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AUC,Test result variable(s): MLA
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.810	0.035	0.000	0.741–0.879

Demographics, FFR, OCT and angiographic findings

	n	Min	Max	Mean	s.d.	FFR ≤ 0.8	s.d.	FFR > 0.8	s.d.	p value
FFR	151	0.41	0.98	0.81	0.10	0.72	0.07	0.88	0.04	<0.001
Age	151	36.00	81.00	60.41	10.42	61.00	10.19	59.97	10.63	0.55
OCT proximal area	151	2.83	20.56	8.84	3.04	8.45	2.95	9.13	3.09	0.17
OCT distal area	151	1.79	18.38	6.79	2.77	6.23	2.66	7.22	2.80	0.03
Average area	151	2.68	19.47	7.82	2.55	7.34	2.37	8.17	2.64	0.04
Lesion length	151	6.20	65.60	31.33	13.20	35.55	14.52	28.14	11.18	0.001
MLA	151	0.75	5.51	2.21	1.06	1.61	0.62	2.67	1.09	<0.001
%AS average reference		21.51	92.00	70.97	11.80	76.97	8.04	66.44	12.19	<0.001
Proximal reference diameter		1.90	5.11	3.27	0.57	1.25	0.28	1.59	0.36	<0.001
Distal reference diameter		1.51	4.84	2.86	0.58	2.76	0.56	2.98	0.58	0.02
Average reference diameter		1.84	4.97	3.08	0.50	3.00	0.48	3.17	0.51	0.03
Minimum diameter	151	0.84	2.53	1.44	0.37	1.25	0.28	1.59	0.36	<0.001
%Diameter stenosis (vs. average reference diameter)		26.18	83.69	46.78	10.19	50.35	10.17	42.05	8.15	<0.001
FFR ≤ 0.8		65	43%			65		86
Vessel	LAD	80	53.30%			47 (72.3%)		33 (38.4%)		<0.001
	RCA	38	25.30%
	LCX	33	21.85%
Male		127	84.10%			56 (86.2%)		71 (82.6%)		0.55
Smoker		46	30.50%			23 (35.4%)		23 (26.7%)		0.253
Hypertension		116	76.80%			45 (69.2%)		71 (82.6%)		0.055
Dyslipidemia		121	80310%			50 (76.9%)		71 (82.6%)		0.341
Diabetes mellitus		47	31.10%			20 (30.8%)		27 (31.4%)		0.93

j_jce-2026-0003_utab_003

AUCTest result variable(s): MLA x
Area	Std. Error^a	P	Asymptotic 95% CI
0.835	0.045	0.000	0.747–0.922

j_jce-2026-0003_utab_002

AUCTest result variable(s): PAS
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.761	0.039	0.000	0.685–0.836

j_jce-2026-0003_utab_009

AUCTest result variable(s): MLA x
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.866	0.069	0.004	0.731–1.000

j_jce-2026-0003_utab_008

AUCTest result variable(s): MLA x
Area	Std. Error^a	Asymptotic Sig.^b	Asymptotic 95% CI
0.916	0.046	0.000	0.826–1.000

Univariate predictors for FFR ≤ 0_8

	B	p value	Exp(B) (95% CI)
LAD location	1.434	0.000	4.19 (2.09-8.41)
OCT proximal reference area	0.077	0.173	0.93 (0.83-1.03
OCT distal reference area	0.140	0.034	0.87 (0.76-0.99)
Average reference area	0.138	0.050	0.87 (0.76-1)
Lesion length	0.045	0.001	1.05 (1.02-1.07
MLA	1.538	0.000	0.21 (0.12-0.38)
PAS vs. RA	0.110	0.000	1.12 (1.07-1.17)
PAS vs. proximal reference	0.103	0.000	1.11 (1.06-1.16)
PAS vs. distal reference	0.071	0.000	1.07 (1.04-1.11)

Multivariate predictors for FFR ≤ 0_8

	B	Wald	p value	Exp(B) (95% CI)
MLA	-2.317	27.369	0.000	0.099 (0.041 - 0.235)
LAD location	2.345	20.161	0.000	10.434 (3.749 – 29.04)
Lesion length	0.045	6.361	0.012	1.046 (1.01 – 1.084)
OCT distal reference area	0.241	5.215	0.022	1.273 (1.035 – 1.566)

The Value of Optical Coherence Tomography Parameters in Estimating Non-Critical Lesions in Patients with Acute Myocardial Infarction

Figures & Tables

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Demographics, FFR, OCT and angiographic findings

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Univariate predictors for FFR ≤ 0_8

Multivariate predictors for FFR ≤ 0_8

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