Pro-atherogenic and prothrombotic mechanisms of Lp(a)4
| Variables | All patients (n = 80) | With metoprolol (n = 40) | Without metoprolol (n = 40) | p value |
|---|---|---|---|---|
| Age (years), mean ± s.d. | 26.8 ± 4.54 | 25.90 ± 4.67 | 27.80 ± 4.25 | 0.67 |
| Gestational week at delivery, mean ± s.d. | 37.61 ± 1.17 | 37.20 ± 1.41 | 38.03 ± 0.66 | 0.06 |
| Birth weight, mean ± s.d. | 2,787.87 ± 356.09 | 2,746.50 ± 379.99 | 2,829.25 ± 330.06 | 0.30 |
| Body mass index, n (%) | 34 (42.5) | 12 (30.0) | 22 (55.0) | 0.041 |
| Urban environment, n (%) | 65 (81.2) | 36 (90.0) | 29 (72.5) | 0.083 |
| Preeclampsia, n (%) | 67 (83.8) | 38 (95.0) | 29 (72.5) | 0.006 |
| Prematurity, n (%) | 5 (6.2) | 5 (12.5) | 0 (0.0) | 0.021 |
| IUGR, n (%) | 8 (10.0) | 4 (10.0) | 4 (10.0) | 0.98 |
| Cesarean section | 72 (90.0) | 37 (92.5) | 35 (87.5) | 0.71 |
| Doppler changes in the 3rd trimester | 35 (43.8) | 18 (45.0) | 17 (42.5) | 0.82 |
| Oligoamnios | 6 (7.5) | 4 (10.0) | 2 (5.0) | 0.39 |
| CTG affected before birth | 27 (33.8) | 17 (42.5) | 10 (25.0) | 0.15 |
| Male sex, n (%) | 21 (26.2) | 11 (27.5) | 10 (25.0) | 0.79 |
| G1, n (%) | 53 (66.2) | 27 (67.5) | 26 (65.0) | 0.96 |
| G2, n (%) | 23 (28.7) | 11 (27.5) | 12 (30.0) | |
| G2, n (%) | 4 (5.0) | 5 (5.0) | 2 (5.0) | |
| P1, n (%) | 70 (87.5) | 34 (85.0) | 36 (90.0) | 0.73 |
| P2, n (%) | 10 (12.5) | 6 (15.0) | 4 (10.0) | |
| Prophylaxis with acetylsalicilic acid, n (%) | 29 (36.2) | 10 (25.0) | 19 (47.5) | 0.062 |
The relationship between preeclampsia and treatment with metoprolol and acetylsalicylic acid
| Variables | Odds ratio | 95% confidence interval | p value |
|---|---|---|---|
| Treatment with metoprolol | 0.0886 | 0.0171 to 0.4600 | 0.0039 |
| Prophylaxis with acetylsalicylic acid | 0.1456 | 0.0274 to 0.7736 | 0.0237 |