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Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review Cover

Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review

Open Access
|Jan 2026

References

  1. Podoll AS, Kozar R, Holcomb JB, Finkel KW. Incidence and outcome of early acute kidney injury in critically-ill trauma patients. PLoS One. 2013;8(10):e77376. doi: 10.1371/journal.pone.0077376.
  2. Centers for Disease Control NCfIPaC. Web-based Injury Statistics Query and Reporting System (WISQARS) [online] Accessed February 14, 2017. [Available from: https://www.cdc.gov/injury/wisqars/leadingcauses.html.
  3. Haines RW, Fowler AJ, Kirwan CJ, Prowle JR. The incidence and associations of acute kidney injury in trauma patients admitted to critical care: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2019;86(1):141–147. doi: 10.1097/TA.0000000000002085.
  4. Lopes MCBT, Bustillo RA, Whitaker IY. In-hospital complications after trauma due to road traffic accidents. Eur J Trauma Emerg Surg. 2023 Aug;49(4):1855–1862. doi: 10.1007/s00068-023-02264-2.
  5. Gunst M, Ghaemmaghami V, Gruszecki A, Urban J, Frankel H, Shafi S. Changing epidemiology of trauma deaths leads to a bimodal distribution. Proc (Bayl Univ Med Cent). 2010;23(4):349–54. doi: 10.1080/08998280.2010.11928649.
  6. Kleber C, Giesecke MT, Tsokos M, Haas NP, Schaser KD, Stefan P, Buschmann CT. Overall distribution of trauma-related deaths in Berlin 2010: advancement or stagnation of German trauma management? World J Surg. 2012;36(9):2125–30. doi: 10.1007/s00268-012-1650-9.
  7. Qi P, Huang MJ, Wu W, Ren XW, Zhai YZ, Qiu C, Zhu HY. Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury. Chin J Traumatol. 2024;27(2):97–106. doi: 10.1016/j.cjtee.2024.01.002.
  8. Perkins ZB, Captur G, Bird R, Gleeson L, Singer B, O’Brien B. Trauma induced acute kidney injury. PLoS One. 2019;14(1):e0211001. doi: 10.1371/journal.pone.0211001.
  9. Lai WH, Rau CS, Wu SC, Chen YC, Kuo PJ, Hsu SY, Hsieh CH, Hsieh HY. Post-traumatic acute kidney injury: a cross-sectional study of trauma patients. Scand J Trauma Resusc Emerg Med. 2016;24(1):136. doi: 10.1186/s13049-016-0330-4.
  10. Bihorac A, Delano MJ, Schold JD, Lopez MC, Nathens AB, Maier RV, Layon AJ, Baker HV, Moldawer LL. Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg. 2010; 252(1):158–65. doi: 10.1097/SLA.0b013e3181deb6bc.
  11. Shashaty MGS, Meyer NJ, Localio AR, Gallop R, Bellamy SL, Holena DN, Lanken PN, Kaplan S, Yarar D, Kawut SM, Feldman HI, Christie JD. African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients. J Crit Care. 2012;27(5):496–504. doi: 10.1016/j.jcrc.2012.02.002.
  12. Bagshaw SM, George C, Gibney RT, Bellomo R. A multi-center evaluation of early acute kidney injury in critically ill trauma patients. Ren Fail. 2008;30(6):581–589. doi: 10.1080/08860220802134649.
  13. Harrois A, Soyer B, Gauss T, Hamada S, Raux M, Duranteau J, Traumabase® Group. Prevalence and risk factors for acute kidney injury among trauma patients: a multicenter cohort study. Crit Care. 2018; 22(1):344. doi: 10.1186/s13054-018-2265-9.
  14. Li N, Zhao WG, Zhang WF. Acute kidney injury in patients with severe traumatic brain injury: implementation of the acute kidney injury network stage system. Neurocrit Care. 2011;14(3):377–81. doi: 10.1007/s12028-011-9511-1.
  15. Ahmed M, Sriganesh K, Vinay B, Umamaheswara Rao GS. Acute kidney injury in survivors of surgery for severe traumatic brain injury: incidence, risk factors, and outcome from a tertiary neuroscience center in India. Br J Neurosurg. 2015;29(4):544–8. doi: 10.3109/02688697.2015.1016892.
  16. Eriksson M, Brattström O, Mårtensson J, Larsson E, Oldner A. Acute kidney injury following severe trauma: Risk factors and long-term outcome. J Trauma Acute Care Surg. 2015;79(3):407–12. doi: 10.1097/TA.0000000000000727.
  17. Søvik S, Isachsen MS, Nordhuus KM, Tveiten CK, Eken T, Sunde K, Brurberg KG, Beitland S. Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis. Intensive Care Med. 2019; 45(4):407–19. doi: 10.1007/s00134-019-05535-y.
  18. Moore EM, Bellomo R, Nichol A, Harley N, Macisaac C, Cooper DJ. The incidence of acute kidney injury in patients with traumatic brain injury. Ren Fail. 2010;32(9):1060–5. doi: 10.3109/0886022X.2010.510234.
  19. Leditzke K, Wagner MEH, Neunaber C, Clausen JD, Winkelmann M. Neutrophil Gelatinase-associated Lipocalin Predicts Post-Traumatic Acute Kidney Injury in Severely Injured Patients. In Vivo. 2021;35(5):2755–2762. doi: 10.21873/invivo.12560.
  20. Yasuda R, Suzuki K, Okada H, Ishihara T, Minamiyama T, Kamidani R, Kitagawa Y, Fukuta T, Suzuki K, Miyake T, Yoshida S, Tetsuka N, Ogura S. Urinary liver-type fatty acid-binding protein levels may be associated with the occurrence of acute kidney injury induced by trauma. Front Med (Lausanne). 2024;11:1346183. doi: 10.3389/fmed.2024.1346183.
  21. Wu GY, Zhuang K, Liu Y, Wang ZF. [Value of urinary liver fatty acid-binding protein in assessing severity of brain trauma and predicting acute kidney injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36(11):1527–1530.
  22. Ostermann M, Zarbock A, Goldstein S, Kashani K, Macedo E, Murugan R, Bell M, Forni L, Guzzi L, Joannidis M, Kane-Gill SL, Legrand M, Mehta R, Murray PT, Pickkers P, Plebani M, Prowle J, Ricci Z, Rimmelé T, Rosner M, Shaw AD, Kellum JA, Ronco C. Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement. JAMA Netw Open. 2020;3(10):e2019209. doi: 10.1001/jamanetworkopen.2020.19209.
  23. Heegard KD, Stewart IJ, Cap AP, Sosnov JA, Kwan HK, Glass KR, Morrow BD, Latack W, Henderson AT, Saenz KK, Siew ED, Ikizler TA, Chung KK. Early acute kidney injury in military casualties. J Trauma Acute Care Surg. 2015;78(5):988–93. doi: 10.1097/TA.0000000000000607.
  24. Baitello AL, Marcatto G, Yagi RK. Risk factors for injury acute renal in patients with severe trauma and its effect on mortality. J Bras Nefrol. 2013;35(2):127–31. doi: 10.5935/0101-2800.20130021.
  25. Skinner DL, Hardcastle TC, Rodseth RN, Muckart DJJ. The incidence and outcomes of acute kidney injury amongst patients admitted to a level I trauma unit. Injury. 2014;45(1):259–64. doi: 10.1016/j.injury.2013.07.013.
  26. Elterman J, Zonies D, Stewart I, Fang R, Schreiber M. Rhabdomyolysis and acute kidney injury in the injured war fighter. J Trauma Acute Care Surg. 2015;79(4 Suppl 2):S171–4. doi: 10.1097/TA.0000000000000572.
  27. Stewart IJ, Sosnov JA, Howard JT, Chung KK. Acute kidney injury in critically injured combat veterans: a retrospective cohort study. Am J Kidney Dis. 2016;68(4):564–70. doi: 10.1053/j.ajkd.2016.03.419.
  28. Haines RW, Lin SP, Hewson R, Kirwan CJ, Torrance HD, O’Dwyer MJ, West A, Brohi K, Pearse RM, Zolfaghari P, Prowle JR. Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model. Sci Rep. 2018;8(1):3665. doi: 10.1038/s41598-018-21929-2.
  29. Martinez T, Harrois A, Codorniu A, Mongardon N, Pissot M, Popoff B, Leone M, Delhaye N, Vicaut E, Mathais Q, Legros V, Hanouz JL, Gatulle N, Ramonda V, Cohen B, Boutonnet M, Pottecher J, Libert N; Traumabase Group. Evaluation of severe rhabdomyolysis on day 30 mortality in trauma patients admitted to intensive care: a propensity score analysis of the Traumabase registry. Crit Care. 2024;28(1):382. doi: 10.1186/s13054-024-05158-w.
  30. Honiden S, McArdle JR. Obesity in the Intensive Care Unit. Clin Chest Med. 2009;30(3):581–99, x. doi: 10.1016/j.ccm.2009.05.007.
  31. Schetz M, De Jong A, Deane AM, Druml W, Hemelaar P, Pelosi P, Pickkers P, Reintam-Blaser A, Roberts J, Sakr Y, Jaber S. Obesity in the critically ill: a narrative review. Intensive Care Med. 2019;45(6):757–769. doi: 10.1007/s00134-019-05594-1.
  32. Levey AS. Defining AKD: The Spectrum of AKI, AKD, and CKD. Nephron. 2022;146(3):302–305.
  33. Messerer DAC, Halbgebauer R, Nilsson B, Pavenstädt H, Radermacher P, Huber-Lang M. Immunopathophysiology of trauma-related acute kidney injury. Nat Rev Nephrol. 2021;17(2):91–111. doi: 10.1038/s41581-020-00344-9.
  34. Evans RG, Gardiner BS, Smith DW, O’Connor PM. Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis. Am J Physiol Renal Physiol. 2008;295(5):F1259–70. doi: 10.1152/ajprenal.90230.2008.
  35. Bellomo R. Bench-to-bedside review: lactate and the kidney. Crit Care. 2002;6(4):322–6. doi: 10.1186/cc1518.
  36. Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury 2007;38(12):1336–45. doi: 10.1016/j.injury.2007.10.003.
  37. Harrois A, Libert N, Duranteau J. Acute kidney injury in trauma patients. Curr Opin Crit Care. 2017;23(6):447–456. doi: 10.1097/MCC.0000000000000463.
  38. Cha J, Clements TW, Ball CG, Kirkpatrick AW, Bax T, Mayberry J. Damage control packing: How long can it stay? Am J Surg. 2025:245:116232. doi: 10.1016/j.amjsurg.2025.116232.
  39. Jones DG, Nantais J, Rezende-Neto JB, Yazdani S, Vegas P, Rizoli S. Crystalloid resuscitation in trauma patients: deleterious effect of 5L or more in the first 24h. BMC Surg. 2018;18(1):93. doi: 10.1186/s12893-018-0427-y.
  40. Tubert P, Kalimouttou A, Bouzat P, David JS, Gauss T. Are crystalloid-based fluid expansion strategies still relevant in the first hours of trauma induced hemorrhagic shock? Crit Care. 2024 Dec 18;28(1):416. doi: 10.1186/s13054-024-05185-7.
  41. Hultström M. Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock-induced acute kidney injury. Acta Physiol (Oxf). 2013;209(1):11–25. doi: 10.1111/apha.12147.
  42. Mayeur N, Minville V, Jaafar A, Allard J, Al Saati T, Guilbeau-Frugier C, Fourcade O, Girolami JP, Schaak S, Tack I. Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice. Crit Care Med. 2011;39(9):2131–8. doi: 10.1097/CCM.0b013e31821f04f0.
  43. Van Meurs M, Wulfert FM, Jongman RM, Schipper M, Houwertjes MC, Vaneker M, Scheffer GJ, Teppema LJ, Aarts LPHJ, Heeringa P, Zijlstra JG, Molema G. Hemorrhagic shock-induced endothelial cell activation in a spontaneous breathing and a mechanical ventilation hemorrhagic shock model is induced by a proinflammatory response and not by hypoxia. Anesthesiology. 2011;115(3):474–82. doi: 10.1097/ALN.0b013e318229a640.
  44. Liu GQ, Zuo XH, Jiang LN, Zhang YP, Zhang LM, Zhao ZG, Niu CY. Inhibitory effect of post-hemorrhagic shock mesenteric lymph drainage on the HMGB1 and RAGE in mouse kidney. Ren Fail. 2016;38(1):131–6. doi: 10.3109/0886022X.2015.1105026.
  45. Tran A, Yates J, Lau A, Lampron J, Matar M. Permissive hypotension versus conventional resuscitation strategies in adult trauma patients with hemorrhagic shock: A systematic review and meta-analysis of randomized controlled trials. J Trauma Acute Care Surg. 2018;84(5):802–808. doi: 10.1097/TA.0000000000001816.
  46. Albreiki M, David Voegeli D. Permissive hypotensive resuscitation in adult patients with traumatic haemorrhagic shock: a systematic review. Eur J Trauma Emerg Surg. 2018 Apr;44(2):191–202. doi: 10.1007/s00068-017-0862-y.
  47. Rossaint R, Afshari A, Bouillon B, Cerny V, Cimpoesu D, Curry N, et al. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Crit Care. 2023;27(1):80. doi: 10.1186/s13054-023-04327-7.
  48. Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J. Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis. Scand J Trauma Resusc Emerg Med. 2018;26(1):107. doi: 10.1186/s13049-018-0572-4.
  49. Ho KH, Tarng YW, Chou YP, Lin HL. Permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock. Scand J Trauma Resusc Emerg Med. 2019;27(1):14. doi: 10.1186/s13049-019-0595-5.
  50. Lou X, Lu G, Zhao M, Jin P. Preoperative fluid management in traumatic shock: a retrospective study for identifying optimal therapy of fluid resuscitation for aged patients. Medicine. 2018;97(8):e9966. doi: 10.1097/MD.0000000000009966.
  51. Edwards M, Ley E, Mirocha J, Hadjibashi AA, Margulies DR, Salim A. Defining hypotension in moderate to severely injured trauma patients: raising the bar for the elderly. Am Surg. 2010;76(10):1035–8.
  52. Benhamed A, Batomen B, Boucher V, Yadav K, Isaac CJ, Mercier E, Bernard F, Blais-L’écuyer J, Tazarourte K, Emond M. Relationship between systolic blood pressure and mortality in older vs younger trauma patients - a retrospective multicentre observational study. BMC Emerg Med. 2023 Sep 19;23(1):105. doi: 10.1186/s12873-023-00863-1.
  53. Bridges LC, Waibel BH, Newell MA. Permissive Hypotension: Potentially Harmful in the Elderly? A National Trauma Data Bank Analysis. Am Surg. 2015 Aug;81(8):770–7.
  54. Ko A, Harada MY, Barmparas G, Smith EJT, Birch K, Barnard ZR, Yim DA, Ley EJ. Limit Crystalloid Resuscitation after Traumatic Brain Injury. Am Surg. 2017;83(12):1447–1452.
  55. Ley EJ, Clond MA, Srour MK, Barnajian M, Mirocha J, Margulies DR, Salim A. Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. J Trauma. 2011;70(2):398–400. doi: 10.1097/TA.0b013e318208f99b.
  56. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs. chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308(15):1566–72. doi: 10.1001/jama.2012.13356.
  57. Lee JY, Hong TH, Lee KW, Jung MJ, Lee JG, Lee SH. Hyperchloremia is associated with 30-day mortality in major trauma patients: a retrospective observational study. Scand J Trauma Resusc Emerg Med. 2016;24(1):117. doi: 10.1186/s13049-016-0311-7.
  58. U.S. Food and Drug Administration. FDA Safety Communication: boxed warning on increased mortality and severe renal injury, and additional warning on risk of bleeding, for use of hydroxyethyl starch solutions in some settings, 2013. Available at: http://www.fda.gov/biologicsbloodvaccines/safetyavailability/ucm358271.htm. Accessed November 25, 2013
  59. Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, Cooper C, Liu PY, Neff M, Awan AB, Warner K, Maier RV. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg. 2008;143(2):139–48; discussion 149. doi: 10.1001/archsurg.2007.41.
  60. Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG. Effect of a Buffered Crystalloid Solution vs. Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial. JAMA. 2015;314(16):1701–10. doi: 10.1001/jama.2015.12334.
  61. Zampieri FG, Machado FR, Biondi RS, Freitas FGR, Veiga VC, Figueiredo RC, Lovato WJ, Amêndola CP, Serpa-Neto A, Paranhos JLR, Guedes MAV, Lúcio EA, Oliveira-Júnior LC, Lisboa TC, Lacerda FH, Maia IS, Grion CMC, Assunção MSC, Manoel ALO, Silva-Junior JM, Duarte P, Soares RM, Miranda TA, de Lima LM, Gurgel RM, Paisani DM, Corrêa TD, Azevedo LCP, Kellum JA, Damiani LP, da Silva NB, Cavalcanti AB; BaSICS investigators and the BRICNet members. Effect of Intravenous Fluid Treatment With a Balanced Solution vs. 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021;326(9):1–12. doi: 10.1001/jama.2021.11684.
  62. Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, Delaney A, Gallagher M, Gattas D, Li Q, Mackle D, Mysore J, Saxena M, Taylor C, Young P, Myburgh J; PLUS Study Investigators and the Australian New Zealand Intensive Care Society Clinical Trials Group. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med. 2022;386(9):815–826. doi: 10.1056/NEJMoa2114464. Epub 2022 Jan 18.
  63. Semler MW, Self WHS, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL, Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW; SMART Investigators and the Pragmatic Critical Care Research Group. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018;378(9):829–839. doi: 10.1056/NEJMoa1711584.
  64. Schaer DJ, Buehler PW. Cell-Free Hemoglobin and Its Scavenger Proteins: New Disease Models Leading the Way to Targeted Therapies. Cold Spring Harb Perspect Med. 2013;3(6):a013433. doi: 10.1101/cshperspect.a013433
  65. Baksaas-Aasen K, Gall LS, Stensballe J, Juffermans NP, Curry N, Maegele M, Brooks A, Rourke C, Gillespie S, Murphy J, Maroni R, Vulliamy P, Henriksen HH, Pedersen KH, Kolstadbraaten KM, Wirtz MR, Kleinveld DJB, Schäfer N, Chinna S, Davenport RA, Naess PA, Goslings JC, Eaglestone S, Stanworth S, Johansson PI, Gaarder C, Brohi K. Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial. Intensive Care Med. 2021 Jan;47(1):49–59. doi: 10.1007/s00134-020-06266-1.
  66. Lier H, Hossfeld B. Massive transfusion in trauma. Curr Opin Anaesthesiol. 2024 Apr 1;37(2):117–124. doi: 10.1097/ACO.0000000000001347.
  67. Liu ZZ, Mathia S, Pahlitzsch T, Wennysia IC, Persson PB, Lai EY, Högner A, Xu MZ, Schubert R, Rosenberger C, Patzak A. Myoglobin facilitates angiotensin II-induced constriction of renal afferent arterioles. Am J Physiol Renal Physiol. 2017;312(5):F908–F916. doi: 10.1152/ajprenal.00394.2016.
  68. Kodadek L, Carmichael Ii SP, Seshadri A, Pathak A, Hoth J, Appelbaum R, Michetti CP, Richard P Gonzalez R. Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document. Trauma Surg Acute Care Open. 2022 Jan 27;7(1):e000836. doi: 10.1136/tsaco-2021-000836.
  69. Michelsen J, Cordtz J, Liboriussen L, Behzadi MT, Ibsen M, Damholt MB, Møller MH, Wiis J. Prevention of rhabdomyolysis-induced acute kidney injury - A DASAIM/DSIT clinical practice guideline. Acta Anaesthesiol Scand 2019;63(5):576–86. doi: 10.1111/aas.13308.
  70. Cote DR, Fuentes E, Elsayes AH, Ross JJ, Quraishi SA. A “crush” course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician. J Anesth 2020;34:585–98. doi: 10.1007/s00540-020-02792-w.
  71. Zeng X, Zhang L, Wu T, Fu P. Continuous renal replacement therapy (CRRT) for rhabdomyolysis. Cochrane Database Syst Rev 2014;6C:D008566. doi: 10.1002/14651858.CD008566.pub2.
  72. Harman PK, Kron IL, McLachlan HD, Freedlender AE, Nolan SP. Elevated intra-abdominal pressure and renal function. Ann Surg. 1982;196(5):594–7. doi: 10.1097/00000658-198211000-00015.
  73. Copur S, Berkkan M, Hasbal NB, Basile C, Kanbay M. Abdominal compartment syndrome: an often overlooked cause of acute kidney injury. J Nephrol. 2022;35(6):1595–1603. doi: 10.1007/s40620-022-01314-z.
  74. Patel DM, Connor MJ Jr. Intra-Abdominal Hypertension and Abdominal Compartment Syndrome: An Underappreciated Cause of Acute Kidney Injury. Adv Chronic Kidney Dis. 2016;23(3):160–6. doi: 10.1053/j.ackd.2016.03.002.
  75. De Waele JJ. Intra-abdominal hypertension and abdominal compartment syndrome. Curr Opin Crit Care. 2022 Dec 1;28(6):695–701. doi: 10.1097/MCC.0000000000000991.
  76. Strang SG, Habes QLM, Van der Hoven B, Tuinebreijer WE, Verhofstad MHJ, Pickkers P, Van Lieshout EMM, Van Waes OJF. Intestinal fatty acid binding protein as a predictor for intra-abdominal pressure-related complications in patients admitted to the intensive care unit; a prospective cohort study (I-Fabulous study). J Crit Care 2021; 63:211–217. doi: 10.1016/j.jcrc.2020.08.023.
  77. Strang SG, Breederveld RS, Cleffken BI, Verhofstad MHJ, Van Waes OJF, Van Lieshout EMM. Prevalence of intra-abdominal hypertension and markers for associated complications among severe burn patients: a multicenter prospective cohort study (BURNIAH study). Eur J Trauma Emerg Surg. 2022;48(2):1137–1149. doi: 10.1007/s00068-021-01623-1.
  78. De Laet IE, Malbrain MLNG, De Waele JJ. A clinician’s guide to management of intra-abdominal hypertension and abdominal compartment syndrome in critically ill patients. Crit Care 2020; 24(1):97. doi: 10.1186/s13054-020-2782-1.
DOI: https://doi.org/10.2478/jccm-2026-0009 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 5 - 19
Submitted on: Jul 23, 2025
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Accepted on: Jan 15, 2026
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Published on: Jan 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Eleni Sertaridou, Christina Alexopoulou, Vasilios Papaioannou, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.