Fig. 1.

Fig. 2.

Fig. 3.

Fig. 4.

Laboratory tests and diuresis
| Laboratory test | Day 1 | Day 3 | Day 5 | Day 7 | Day 8 | Day 9 | Day 10 | Day 12 | Day 14 | Day 16 | Day 18 | Day 20 | Day 23 | Reference Range |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Leukocytes | 32500 | 28300 | 23700 | 20000 | 25100 | 27200 | 31100 | 27400 | 21600 | 17500 | 13100 | 9900 | 10000 | 3600–10000/μL |
| Neutrophils | 28000 | 24200 | 20600 | 17300 | 21000 | 23700 | 26900 | 22100 | 16300 | 11400 | 9600 | 7800 | 7900 | 1400–6500/μL |
| Hemoglobin | 9.33 | 9.4 | 9.2 | 9 | 8.9 | 8.8 | 8.8 | 9.1 | 9.4 | 9.85 | 9.6 | 9.3 | 9.1 | 13–17g/dL |
| Platelets | 154000 | 143000 | 150000 | 149000 | 133000 | 121000 | 112000 | 117000 | 126000 | 123000 | 117000 | 119000 | 116000 | 150000–450000/μL |
| C reactive protein | 140.5 | 122.5 | 110.5 | 70 | 140 | 219 | 243 | 194 | 152 | 93 | 40 | 10 | 15 | 0–5mg/L |
| Procalcitonin | 14.54 | 5 | 12.3 | 8 | 6 | <0.5mg/L | ||||||||
| Presepsin | 1369 | 714 | 1236 | 744 | 432 | 100–200 pg/mL | ||||||||
| NT-proBNP | 23614 | 21500 | <125pg/mL | |||||||||||
| AST | 24 | 25 | 18 | 22 | 18 | 23 | 30 | 5–34U/L | ||||||
| ALT | 5 | 7 | 6 | 6 | 6 | 7 | 8 | 0–55U/L | ||||||
| Total bilirubin | 1.42 | 1.37 | 1.27 | 1.22 | 1.09 | 1.26 | 1.41 | 0.2–1.2 mg/dL | ||||||
| Albumin | 3.06 | 3.0 | 3.97–4.94 g/dL | |||||||||||
| Total protein | 6.19 | 6.1 | 6.4–8.3 g/dL | |||||||||||
| INR | 1.17 | 1.04 | 0.94 | 0.9 | 0.92 | 0.96 | 0.8–1.2 | |||||||
| Sodium | 136 | 134 | 134 | 133 | 133 | 132 | 132 | 131 | 130 | 130 | 130 | 130 | 130 | 136–145 mmol/L |
| Potassium | 3.67 | 3.5 | 3.63 | 3.69 | 3.7 | 3.74 | 3.76 | 3.8 | 3.6 | 3.5 | 3.4 | 3.6 | 3.5 | 3.5–5.1 mmol/L |
| Glucose | 94 | 106 | 101 | 95 | 88 | 78 | 83 | 96 | 99 | 94 | 121 | 117 | 104 | 70–105 mg/dL |
| pH | 7.31 | 7.33 | 7.32 | 7.35 | 7.36 | 7.35 | 7.33 | 7.33 | 7.31 | 7.3 | 7.29 | 7.26 | 7.2 | 7.35–7.45 |
| PO2 | 65 | 68 | 70 | 71 | 72 | 71 | 72 | 71 | 70 | 70 | 71 | 70 | 70 | 75–100 mmHg |
| PCO2 | 49 | 44 | 43 | 44 | 46 | 49 | 51 | 53 | 53 | 54 | 54 | 55 | 65 | 35–45 mmHg |
| P(A-a)O2 | 158,95 | 162,2 | 161,45 | 159,2 | 155,7 | 152,95 | 149,45 | 147,95 | 148,95 | 147,7 | 146,7 | 146,45 | 133,95 | mmHg |
| FShunt | 39 | 22 | 20 | 21 | 20 | 21 | 32 | 30 | 26 | 28 | 30 | 33 | 37 | % |
| HCO3 | 18 | 19 | 21 | 22 | 23 | 22 | 20 | 19 | 19 | 18 | 18 | 17 | 20 | 22–26mEq/L |
| SaO2 | 75 | 88 | 90 | 89 | 90 | 89 | 84 | 85 | 87 | 86 | 85 | 80 | 78 | 95–100% |
| Lactate | 3.6 | 3.5 | 3.4 | 3.1 | 3.2 | 3.3 | 3.5 | 3.1 | 2.9 | 2.8 | 3.0 | 3.1 | 3.2 | <2mmol/L |
| Urea | 117 | 89 | 87 | 81 | 70 | 74 | 72 | 71 | 72 | 79 | 85 | 82 | 79 | 19.04–44.08 mg/dL |
| Creatinine | 2.85 | 2.31 | 2.23 | 2.01 | 1.62 | 1.85 | 1.9 | 1.76 | 1.79 | 2.07 | 2.11 | 2.15 | 2.16 | 0.72–1.25 mg/dL |
| Diuresis | 3L | 3.2L | 3L | 2.8L | 2.9L | 3.3L | 3.1L | 3L | 2.7L | 2.8L | 2.6L | 2.7L | 2.5L |