Have a personal or library account? Click to login
The effect of antiseizure medication on mortality in spontaneous aneurysmal subarachnoid hemorrhage Cover

The effect of antiseizure medication on mortality in spontaneous aneurysmal subarachnoid hemorrhage

Open Access
|Apr 2025

References

  1. Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2023;54:E314–70. doi: 10.1161/STR.0000000000000436.
  2. Etminan N, Chang HS, Hackenberg K, et al. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A Systematic Review and Meta-analysis. JAMA Neurol 2019;76:588–97. doi: 10.1001/JAMANEUROL.2019.0006.
  3. Rass V, Helbok R. Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage. Curr Neurol Neurosci Rep 2019;19:1–9. doi: 10.1007/S11910-019-0990-3/FIGURES/1.
  4. De Marchis GM, Pugin D, Meyers E, et al. Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome. Neurology 2016;86:253. doi: 10.1212/WNL.0000000000002281.
  5. Mehra A, Gomez F, Bischof H, Diedrich D, Laudanski K. Cortical Spreading Depolarization and Delayed Cerebral Ischemia; Rethinking Secondary Neurological Injury in Subarachnoid Hemorrhage. International Journal of Molecular Sciences 2023;24:9883. doi: 10.3390/IJMS24129883.
  6. Connolly ES, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage. Stroke 2012;43:1711–37. doi: 10.1161/STR.0B013E3182587839.
  7. Naidech AM, Kreiter KT, Janjua N, et al. Phenytoin Exposure Is Associated With Functional and Cognitive Disability After Subarachnoid Hemorrhage. Stroke 2005;36:583–7. doi: 10.1161/01.STR.0000141936.36596.1E.
  8. Connolly ES, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage. Stroke 2012;43:1711–37. doi: 10.1161/STR.0B013E3182587839.
  9. Marigold R, Günther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database of Systematic Reviews 2013;2013. doi: 10.1002/14651858.CD008710.PUB2/MEDIA/CDSR/CD008710/IMAGE_T/TCD008710-AFIG-FIG01.PNG.
  10. Fiani B, Andraos C, Mabry I, Siddiqi J. A Comparison of Seizure Prophylaxis: Phenytoin Versus Levetiracetam. Cureus 2021;13(5):e14956. doi: 10.7759/cureus.14956.
  11. Szaflarski JP, Sangha KS, Lindsell CJ, Shutter LA. Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxis. Neurocrit Care 2010;12:165–72. doi: 10.1007/S12028-009-9304-Y/TABLES/4.
  12. Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2022;53:E282–361. doi: 10.1161/STR.0000000000000407.
  13. Johnson AEW, Pollard TJ, Shen L, et al. MIMIC-III, a freely accessible critical care database. Scientific Data 2016;3:1–9. doi: 10.1038/sdata.2016.35.
  14. Elm E von, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 2007;335(7624):806–8 doi: 10.1136/BMJ.39335.541782.AD.
  15. Van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care 2009;47:626–33. doi: 10.1097/MLR.0B013E31819432E5.
  16. Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 1968;28:14–20. doi: 10.3171/JNS.1968.28.1.0014.
  17. Frontera JA, Claassen J, Schmidt JM, et al. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery 2006;59:21–7. doi: 10.1227/01.NEU.0000243277.86222.6C.
  18. R: The R Project for Statistical Computing n.d. https://www.r-project.org/ (accessed March 17, 2024).
  19. Marigold R, Günther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database of Systematic Reviews 2013;2013. doi: 10.1002/14651858.CD008710.PUB2/MEDIA/CDSR/CD008710/IMAGE_T/TCD008710-AFIG-FIG01.PNG.
  20. Chumnanvej S, Dunn IF, Kim DH. Three-day phenytoin prophylaxis is adequate after subarachnoid hemorrhage. Neurosurgery 2007;60:99–102. doi: 10.1227/01.NEU.0000249207.66225.D9.
  21. Naidech AM, Kreiter KT, Janjua N, et al. Phenytoin Exposure Is Associated With Functional and Cognitive Disability After Subarachnoid Hemorrhage. Stroke 2005;36:583–7. doi: 10.1161/01.STR.0000141936.36596.1E.
  22. Szaflarski JP, Sangha KS, Lindsell CJ, Shutter LA. Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxis. Neurocrit Care 2010;12:165–72. doi: 10.1007/S12028-009-9304-Y/METRICS.
  23. Glaser AC, Kanter JH, Martinez-Camblor P, et al. The Effect of Antiseizure Medication Administration on Mortality and Early Posttraumatic Seizures in Critically Ill Older Adults with Traumatic Brain Injury. Neurocrit Care 2022;37(2):538–546. doi: 10.1007/S12028-022-01531-1.
  24. Kondziella D, Friberg CK, Wellwood I, Reiffurth C, Fabricius M, Dreier JP. Continuous EEG monitoring in aneurysmal subarachnoid hemorrhage: a systematic review. Neurocrit Care 2015;22:450–61. doi: 10.1007/S12028-014-0068-7.
DOI: https://doi.org/10.2478/jccm-2025-0014 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 173 - 182
Submitted on: Sep 13, 2024
Accepted on: Feb 24, 2025
Published on: Apr 30, 2025
Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 John Harold Kanter, Adam C. Glaser, Pablo Martinez-Camblor, Jakob V.E. Gerstl, Anna B. Lebouille-Veldman, Harshit Arora, Lauren Buhl, Myles D. Boone, Christopher S. Ogilvy, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.