References
- Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105–20.
- Vallersnes OM, Jacobsen D, Ekeberg Ø, et al. Mortality, morbidity and follow-up after acute poisoning by substances of abuse: A prospective observational cohort study. Scand J Public Health. 2019 Jun;47(4):452–461.
- Earnest JD, Hatch MR, Hurlocker MC. Quality of Life and Opioid Use Motives: Direct and Indirect Associations with Risky Opioid Use in a Community Sample of Adults. Subst Use Misuse. 2022;57(14):2117–2125.
- Stein C. The control of pain in peripheral tissue by opioids. N Engl J Med. 1995 Jun 22;332(25):1685–90.
- Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009 Sep;10(9):895–926.
- Schäfer M, Imai Y, Uhl GR et al. Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia. Eur J Pharmacol. 1995 Jun 12;279(2–3):165–9.
- Stein, C., Machelska, H. and Binder, W et al. Peripheral opioid analgesia. Curr Opin Pharmacol. 2001;1(1), pp. 62–65.
- Perrot, S., Guilbaud, G., & Kayser, V. Effects of intraplantar morphine on paw edema and pain-related behaviour in a rat model of repeated acute inflammation. Pain, 1999; 83(2), 249–257.
- Hassan AH, Ableitner A, Stein C, et al. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience. 1993 Jul;55(1):185–95.
- Sauer RS, Hackel D, Morschel L, et al. Toll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation. Mol Pain. 2014 Feb 6;10:10.
- Celik MO, Labuz D, Henning K, et al. Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides. Brain Behav Immun. 2016; 57:227–242.
- Cheah M, Fawcett JW, Andrews MR. Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test. Bio Protoc. 2017 Aug 20;7(16):e2506.
- Stein C. Peripheral mechanisms of opioid analgesia. Anesth Analg. 1993 Jan;76(1):182–91.
- Wood A. New Method of Treating Neuralgia by the Direct Application of Opiates to the Painful Points. Edinb Med Surg J. 1855 Apr 1;82(203):265–281.
- Millan MJ. Multiple opioid systems and pain. Pain. 1986 Dec;27(3):303–347
- Stein C. Targeting pain and inflammation by peripherally acting opioids. Front Pharmacol. 2013 Sep 23;4:123.
- Cayla, C., Labuz, D., Machelska, H., et al. Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors. Anesthesiology 116. 2012; 448–457.
- Stein, C., & Machelska, H. Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy. Pharmacological Reviews. 2011;63(4), 860–881.
- Antonijevic I, Mousa SA, Schäfer M et al. Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci. 1995 Jan;15(1 Pt 1):165–72.
- Kalso E, Smith L, McQuay HJ et al. No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphine. Pain. 2002 Aug;98(3):269–275.
- Vadivelu N, Mitra S, Hines RL. Peripheral opioid receptor agonists for analgesia: a comprehensive review. J Opioid Manag. 2011 Jan–Feb;7(1):55–68.
- Stein, C. Opioid Receptors. Annual Review of Medicine. 2016; 67(1), 433–451.
- Ji, R.-R. et al. Expression of μ-, δ-, and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J. Neurosci. 1995; 15, 8156–8166.
- Stein C, Schäfer M, Machelska H. Attacking pain at its source: new perspectives on opioids. Nat Med. 2003 Aug;9(8):1003–8.
- Hassan AH, Ableitner A, Stein C, et al. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience. 1993 Jul;55(1):185–95.
- Mousa SA, Zhang Q, Sitte N, et al. Beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. J Neuroimmunol. 2001 Apr 2;115(1–2):71–8.
- Fehrenbacher JC, Vasko MR, Duarte DB. Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the rat. Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.4.
- Patil, K.R.; Mahajan, U.B.; Unger, B.S.; et al. Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals. Int. J. Mol. Sci. 2019, 20, 4367.
- Stein C., Küchler S. Targeting inflammation and wound healing by opioids. Trends Pharmacol Sci. 2013;Vol 34(6):303–312
- Fehrenbacher, J. C., Vasko, M. R., & Duarte, D. B. Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the rat. Current protocols in pharmacology. 2012; Chapter 5, Unit5.4.