Table 1.
Comparison of withdrawal times between the control and experimental groups depending on the time morphine was administered.
| Mann-Whitney U | P value | |||
|---|---|---|---|---|
| Group control 1 – 0.9% saline | 10 | 5.742 ± 2.452 | 27.500 | 0.089 |
| Group 2 – morphine 5 mg/kg | 10 | 7.658 ± 2.253 | ||
| Group control 3 – 0.9% saline (3h) | 9 | 5.146 ± 2.212 | 12.000 | 0.012* |
| Group 4 - morphine 5 mg/kg (3h) | 9 | 9.187 ± 3.389 | ||
| Group control 5 – 0.9% saline (6 h) | 10 | 3.539 ± 1.161 | 17.000 | 0.011* |
| Group 6 - morphine 5 mg/kg (6 h) | 10 | 5.021 ± 1.427 | ||
| Group control 7 – 0.9% saline (24 h) | 10 | 2.746 ± 0.873 | 23.000 | 0.043* |
| Group 8 - morphine 5 mg/kg (24 h) | 10 | 3.429 ± 0,446 | ||
| Group control 9 – 0,9% saline (48 h) | 10 | 2.980 ± 0.758 | 19.500 | 0.019* |
| Group 10 - morphine 5 mg/kg (48 h) | 10 | 3.836 ± 0.662 |
Fig. 1.
Comparison of the control group vs. morphine group immediately after carragenan administration
Table 2.
Comparison of withdrawal time between the morphine administration groups
| Mann-Whitney U | p value | |||
|---|---|---|---|---|
| Group 2 – morphine 5 mg/kg | 10 | 7.658 ± 2.253 | 30.000 | 0.243 |
| Group 4 - morphine 5 mg/kg (3h) | 9 | 9.187 ± 3.389 | ||
| Group 2 – morphine 5 mg/kg | 9 | 7.658 ± 2.253 | 12.500 | 0.003* |
| Group 6 - morphine 5 mg/kg (6 h) | 9 | 5.021 ± 1.427 | ||
| Group 2 – morphine 5 mg/kg | 10 | 7.658 ± 2.253 | 0.000 | <0.001* |
| Group 8 - morphine 5 mg/kg (24 h) | 10 | 3.429 ± 0.446 | ||
| Group 2 – morphine 5 mg/kg | 10 | 7.658 ± 2.253 | 1.000 | <0.001* |
| Group 10 - morphine 5 mg/kg (48 h) | 10 | 3.836 ± 0.662 | ||
| Group 4 - morphine 5 mg/kg (3h) | 9 | 9.187 ± 3.389 | 11.000 | 0.004 |
| Group 6 - morphine 5 mg/kg (6 h) | 10 | 5.021 ± 1.427 | ||
| Group 4 - morphine 5 mg/kg (3h) | 9 | 9.187 ± 3.389 | 2.000 | <0.001* |
| Group 8 - morphine 5 mg/kg (24 h) | 10 | 3.429 ± 0.446 | ||
| Group 4 - morphine 5 mg/kg (3h) | 9 | 9.187 ± 3.389 | 3.500 | <0.001* |
| Group 10 - morphine 5 mg/kg (48 h) | 10 | 3.836 ± 0.662 | ||
| Group 6 - morphine 5 mg/kg (6 h) | 10 | 5.021 ± 1.427 | 8.000 | 0.001* |
| Group 8 - morphine 5 mg/kg (24 h) | 10 | 3.429 ± 0.446 | ||
| Group 6 - morphine 5 mg/kg (6 h) | 10 | 5.021 ± 1.427 | 20.500 | 0.023 |
| Group 10 - morphine 5 mg/kg (48 h) | 10 | 3.836 ± 0.662 | ||
| Group 8 - morphine 5 mg/kg (24 h) | 10 | 3.429 ± 0.446 | 32.500 | 0.190 |
| Group 10 - morphine 5 mg/kg (48 h) | 10 | 3.836 ± 0.662 |
Fig. 2.
Comparison of the control group vs. morphine group 3 hours after carragenan administration
Fig. 3.
Comparison of the control group vs. morphine group 6 hours after carragenan administration
Fig. 4.
Comparison of the control group vs. morphine group 24 hours after carragenan administration
Fig. 5.
Comparison of the control group vs. morphine group 48 hours after carragenan administration
Fig. 6.
The mean withdrawal time of paws in the 5 experimental groups