Have a personal or library account? Click to login
A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units Cover

A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units

Open Access
|Jul 2024

References

  1. Krahne D, Heymann A, Spies C. How to monitor delirium in the ICU and why it is important. Clinl Effect Nurs. 2006;9:269–79.
  2. Urden L, Stacy K, Rajabpour NM, et al. Study of Predictors of Delirium Incidence in Hospitalized Patients In Intensive Care Units. Nurs Midwife Commun. 2014;26(18):25–35.
  3. Javaherforooshzadeh F, Monajemzadeh SA, Soltanzadeh M, Janatmakan F, Salari A, Saeed H. A Comparative Study of the Amount of Bleeding and Hemodynamic Changes between Dexmedetomidine Infusion and Remifentanil Infusion for Controlled Hypotensive Anesthesia in Lumbar Discopathy Surgery: A Double-Blind, Randomized, Clinical Trial. Anesth Pain Med. 2018;8(2):e66959.
  4. Al Huraizi AR, Al-Maqbali JS, Al Farsi RS, et al. Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study. J Clin Med. 2023;12(16):5346.
  5. Nelson S, Muzyk AJ, Bucklin MH, Brudney S, Gagliardi JP. Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit. BioMed Res Int. 2015;2015:635737.
  6. Daou M, Telias I, Younes M, Brochard L, Wilcox ME. Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?. Front Neurol. 2020;11:549908.
  7. Jeong IS, Cho MK. Factors Affecting Delirium in ICU Patients. Int J Environ Res Public Health. 2023;20(10):5889.
  8. Tran A, Blinder H, Hutton B et al. Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol. Syst Rev. 2016:5(1):154
  9. Pedersen SS, Kirkegaard T, Jørgensen MB, Jørgensen VL. Effects of a screening and treatment protocol with haloperidol on post-cardiotomy delirium: a prospective cohort study. Interact Cardiovasc Thorac Surg. 2014;18(4):438–445.
  10. Pisani MA, Araujo KL, Murphy TE. Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. Crit. Care Med. 2015;43(5):996–1002.
  11. van den Boogaard M, Schoonhoven L, van Achterberg T, van der Hoeven JG, Pickkers P. Haloperidol prophylaxis in critically ill patients with a high risk for delirium. Critical care. 2013;17(1):R9.
  12. Page VJ, Ely EW, Gates S, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir. Med. 2013;1(7):515–523.
  13. Leuch S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet. 2013;382(9896):951–962.
  14. Tamang K, Kc B, Kuikel S, Thapa S. Haloperidol-induced sudden cardiac arrest in a recently detected HIV and hepatitis C patient: A unique case report. SAGE Open Med Case Rep. 2023;11:2050313X231220792.
  15. Collet MO, Caballero J, Sonneville R, et al. Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Med 2018; 44(7): 1081–1089.
  16. Dotson B. Comparing Dexmedetomidine With Haloperidol for the Treatment of Hyperactive Delirium in Nonintubated ICU Patients. Crit Care Med. 2016;44(12):1259–60.
  17. Keating GM. Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting. Drugs. 2015;75(10):1119–30.
  18. Reade MC, Eastwood GM, Bellomo R, et al. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. JAMA. 2016;315(14):1460–8.
  19. Jalonen J, Hynynen M, Kuitunen A, et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. 1997;86:331–345.
  20. Kim Y, Kim SY, Lee JS, Kong HJ, Han DW. Effect of dexmedetomidine on the corrected QT and Tp-e intervals during spinal anesthesia. Yonsei Med J. 2014;55(2):517–522.
  21. Raschi E, Poluzzi E, Godman B, et al. Torsadogenic Risk of Antipsychotics: Combining Adverse Event Reports with Drug Utilization Data across Europe. PLoS ONE 2013;8(11):81208.
  22. Metzger E, Friedman R. Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill. Journal of Clin. Psychopharmacol. 1993;13(2):128–132.
  23. Perrault LP, Denault AY, Carrier M, Cartier R, Bélisle S. Torsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgery. Can J Anaesth. 2000;47(3):251–254.
  24. O’Brien JM, Rockwood RP, Suh KI. Haloperidol-induced torsade de pointes. Ann Pharmacother. 1999;33(10):1046–1050.
  25. Li M, Ramos LG. Drug-Induced QT Prolongation And Torsades de Pointes. P T. 2017;42(7):473–477.
  26. Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010;55(9):934–947.
  27. Burns KM, Greene EA. Long QT syndrome unmasked by dexmedetomidine: a case report. Congenital heart disease. 2014;9(1):E11–E15.
  28. Görges M, Whyte SD, Sanatani S, Dawes J, Montgomery CJ, Ansermino JM. Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study. Paediatric anaesthesia. 2015;25(12):1287–1293.
  29. Fujii E, Fujino K, Fujii M, Furuno M, Sugimoto Y, Takabuchi S, et al. Dexmedetomidine attenuates the positive chronotropic effects of intravenous atropine in patients with bradycardia during spinal anaesthesia: a retrospective study. JA Clinical Reports. 2018;4(1):1–6.
  30. Grmec S, Mally S, Klemen P. Glasgow Coma Scale score and QTc interval in the prognosis of organophosphate poisoning. Acad Emerg Med. 2004;11(9):925–930.
  31. George TK, Chase D, Peter JV, et al. Association between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit. Indian J Crit Care Med. 2015;19(6):326–332)
  32. Ye M, Zhang J, Liu J, Zhang M, Yao F, & Cheng Y. Association Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort Study. Front Cardiovasc Med. 2021;8:756213.
  33. Rabkin SW, Cheng BJ, Thompson DJ. Detailed analysis of the impact of age on the QT interval. J Geriatr Cardiol. 2016;13(9):740–748.
DOI: https://doi.org/10.2478/jccm-2024-0027 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 222 - 231
Submitted on: Sep 15, 2023
Accepted on: Jun 15, 2024
Published on: Jul 31, 2024
Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Ali Haspolat, Fuat Polat, Ali Şefik Köprülü, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.