Fig. 1
The differences between the levels of serum biomarkers on days 0, 1 and 3. A. NLCR time course. Day 0 – Day 1 difference, p<0.0001; Day 0 – Day 3 difference, p<0.0001; Day 1 – Day 3 difference, p<0.0001. B. FIB time course. Day 0 – Day 1 difference, p=0.064; Day 0 – Day 3 difference, p<0.0001; Day 1 – Day 3 difference, p<0.0001. C. CRP time course. Day 0 – Day 1 difference, p=0.449; Day 0 – Day 3 difference, p<0.001; Day 1 – Day 3 difference, p<0.001. C. PCT time course. Day 0 – Day 1 difference, p<0.001; Day 0 – Day 3 difference, p=0.001; Day 1 – Day 3 difference, p<0.001. NLCR, Neutrophil/lymphocyte count ratio; FIB, fibrinogen; CRP, C-reactive protein; PCT, procalcitonin.
Table 1
The dynamical values of NLCR, FIB, CRP and PCT on days 0, 1 and 3. The results are presented as median (IQR).
| Variable | Admission (day 0) | After 24 hours (day 1) | After 72 hours (day 3) |
|---|---|---|---|
| NLCR | 13.4 (6; 22.8) | 6.14 (3.7; 12.86) | 3.63 (2.49; 5.98) |
| FIB (mg/dl) | 606 (475; 753) | 564 (474; 730) | 474 (385; 616) |
| CRP (mg/l) | 157 (102; 232) | 169 (73; 212) | 58.4 (23.5; 109) |
| PCT (ng/dl) | 4.36 (0.51; 22.71) | 3.34 (0.36; 22.06) | 0.78 (0.05; 4.77) |
[i] NLCR, Neutrophil/lymphocyte count ratio; FIB, fibrinogen; CRP, C-reactive protein; PCT, procalcitonin.
Fig. 2
Comparison of proportions of NLCR, FIB, CRP and PCT between days 0 and 1. 1 – patients who registered an increasing or a minor decreasing (<5% of the initial values) of serum biomarkers; 2 – patients who registered a decreasing of serum biomarkers between 5-20%; 3 – patients who registered a decreasing of serum biomarkers between 20-50%; 4 – patients who registered a major decreasing (>50%) of serum biomarkers. NLCR, Neutrophil/lymphocyte count ratio; FIB, fibrinogen; CRP, C-reactive protein; PCT, procalcitonin.
Fig. 3
Comparison of proportions of NLCR, FIB, CRP and PCT between days 1 and 3. 1 – patients who registered an increasing or a minor decreasing (<5% of the value at 24 hours) of serum biomarkers; 2 – patients who registered a decreasing of serum biomarkers between 5-20%; 3 – patients who registered a decreasing of serum biomarkers between 20-50%; 4 – patients who registered a major decreasing (>50%) of serum biomarkers. NLCR, Neutrophil/lymphocyte count ratio; FIB, fibrinogen; CRP, C-reactive protein; PCT, procalcitonin.
Fig. 4
Comparison of proportions of NLCR, FIB, CRP and PCT between days 0 and 3. 1 – patients who registered an increasing or a minor decreasing (<5% of the initial value) of serum biomarkers; 2 – patients who registered a decreasing of serum biomarkers between 5-20%; 3 – patients who registered a decreasing of serum biomarkers between 20-50%; 4 – patients who registered a major decreasing (>50%) of serum biomarkers. NLCR, Neutrophil/lymphocyte count ratio; FIB, fibrinogen; CRP, C-reactive protein; PCT, procalcitonin.