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Diagnostic Challenge of Gastric Glomangioma Mimicking Gastrointestinal Stromal Tumor: A Case Report Cover

Diagnostic Challenge of Gastric Glomangioma Mimicking Gastrointestinal Stromal Tumor: A Case Report

Open Access
|Jun 2026

Figures & Tables

Figure 1.

Contrast-enhanced CT abdomen (arterial phase) showing a round, circumscribed, avidly enhancing mass along the greater curvature of the stomach at the junction of the gastric body and antrum, suspicious for a hypervascular submucosal neoplasm.

Figure 2.

Hematoxylin and eosin (H&E) stained section (10×) demonstrating neoplastic epithelioid cells with round nuclei and indistinct borders arranged around branching capillary-sized vessels lined by endothelial cells, consistent with glomangioma.

Figure 3.

Immunohistochemical staining showing diffuse cytoplasmic positivity for smooth muscle actin (SMA) in tumor cells.

Figure 4.

S100 immunostaining negative in tumor cells, excluding neural differentiation (schwannoma).

Figure 5.

Ki-67 immunostain demonstrating very low proliferative activity (~1%), consistent with benign behavior.

Comparative immunohistochemical profile of gastric submucosal neoplasms

MarkerGGTGISTGastric NETSchwannomaLeiomyomaHemangioma
CD117 (KIT)NegativePositiveNegativeNegativeNegativeNegative
DOG1NegativePositiveNegativeNegativeNegativeNegative
SMAPositiveVariableNegativeNegativePositiveVariable
VimentinPositiveVariableVariablePositivePositiveVariable
S100NegativeNegativeNegativePositiveNegativeNegative
DesminNegativeNegativeNegativeNegativePositiveNegative
CD34Negative*VariableNegativeNegativeNegativePositive
CD31NegativeNegativeNegativeNegativeNegativePositive
ChromograninNegativeNegativePositiveNegativeNegativeNegative
SynaptophysinVariable**NegativePositiveNegativeNegativeNegative
Ki-67Very low (<2%)VariableStratifies gradeLowLowLow
Language: English
Page range: 65 - 69
Published on: Jun 29, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Muhammad Imran, Sameen Bin Naeem, Nahel Chaudhry, Saad Ehsan, Muhammad Awais Majeed, published by Shakuat Khanum Memorial Cancer Hospital and Research Centre
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.