Outcomes of Medulloblastoma Treated with Volumetric Modulated Arc Therapy Craniospinal Irradiation: A Retrospective Study

Muhammad Anas Tahseen Asar; Tabinda Sadaf; Asma Rashid; Aqueel Shahid; Fajar Rafi Ranjha; Raheel Mukhtar; Haniya Rizwan; Ahmad Rashid

doi:10.2478/jcas-2026-0006

.blurhash-client-img { display: none !important; }

Outcomes of Medulloblastoma Treated with Volumetric Modulated Arc Therapy Craniospinal Irradiation: A Retrospective Study

Journal of Cancer and Allied Specialties

Volume 12 (2026): Issue 1 (March 2026)

By: Muhammad Anas Tahseen Asar, Tabinda Sadaf, Asma Rashid, Aqueel Shahid, Fajar Rafi Ranjha, Raheel Mukhtar, Haniya Rizwan and Ahmad Rashid

Open Access

|Apr 2026

Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): Long-term results from a prospective, multicentre trial. Lancet Oncol. 2006;7(10):813–20. doi:10.1016/S1470-2045(06)70867-1.
Open DOI Search in Google Scholar Back to article
Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol. 2006;24(25):4202–8. doi:10.1200/JCO.2006.06.4980.
Open DOI Search in Google Scholar Back to article
Pizer BL, Weston CL, Robinson KJ, Ellison DW, Ironside J, Saran F, et al. Analysis of patients with supratentorial primitive neuroectodermal tumours in the SIOP/UKCCSG PNET3 study. Eur J Cancer. 2006;42(8):1120–8. doi:10.1016/j.ejca.2006.01.062.
Open DOI Search in Google Scholar Back to article
Holupka EJ, Humm JL, Tarbell NJ, Svensson GK. Effect of setup error on the dose across the junction of matching cranial-spinal fields. Int J Radiat Oncol Biol Phys. 1993;27(2):345–52. doi:10.1016/0360-3016(93)90230-2.
Open DOI Search in Google Scholar Back to article
Jefferies S, Rajan B, Ashley S, Traish D, Brada M. Haematological toxicity of cranio-spinal irradiation. Radiother Oncol. 1998;48(1):23–7. doi:10.1016/S0167-8140(98)00047-3.
Open DOI Search in Google Scholar Back to article
Ziemann C, Cremers F, Motisi L, Gaertig L, Guhlich M, Niehaus K, et al. Novel hybrid treatment planning for pediatric craniospinal axis irradiation. Med Dosim. 2024;49:93–101. doi:10.1016/j.meddos.2023.08.011.
Open DOI Search in Google Scholar Back to article
Li S, Wu Z, Lu J, Yu X, Fang H, Tang G, et al. Modified two-isocenter VMAT technique for craniospinal irradiation in pediatric patients. J Appl Clin Med Phys. 2022;23(5):e13580. doi:10.1002/acm2.13580.
Open DOI Search in Google Scholar Back to article
Nigerian VMAT CSI study. Radiother Oncol. 2023;184:109598.
Search in Google Scholar Back to article
Simiele E, Romero IO, Wang JY, Chen Y, Lozko Y, Severyn Y, et al. Automated contouring, treatment planning, and quality assurance for VMAT craniospinal irradiation (VMAT-CSI). Front Oncol. 2024;14:1378449. doi:10.3389/fonc.2024.1378449.
Open DOI Search in Google Scholar Back to article
Packer RJ, Gajjar A, Vezina G, et al. Craniospinal irradiation followed by chemotherapy: Phase III trial. J Clin Oncol. 2006;24(25):4202–8. doi:10.1200/JCO.2006.06.4980.
Open DOI Search in Google Scholar Back to article
Michalski JM, Janss AJ, Vezina G, Packer RJ, et al. Phase III trial of low-dose craniospinal irradiation with chemotherapy for average-risk medulloblastoma. Int J Radiat Oncol Biol Phys. 2016;96(3):937–8. doi:10.1016/j.ijrobp.2016.08.023.
Open DOI Search in Google Scholar Back to article
Nguyen QN, Chang EL, Allen PK, Mahajan A, Woo SY. Benefits of VMAT in craniospinal irradiation. Radiother Oncol. 2022;171: 105–12. doi:10.1016/j.radonc.2022.08.014.
Open DOI Search in Google Scholar Back to article
Chen Y, Yang J, Lu W, Chen J, Zhu J, Xie C, et al. Dosimetric comparison of VMAT and proton therapy for craniospinal irradiation. Int J Radiat Oncol Biol Phys. 2012;82(2):635–41. doi:10.1016/j.ijrobp.2010.12.066.
Open DOI Search in Google Scholar Back to article
Sharma DS, Gupta T, Jalali R, Master Z, Phurailatpam RD, Sarin R. High-precision radiotherapy for craniospinal irradiation: Evaluation of three-dimensional conformal, intensity-modulated and helical tomotherapy techniques. Br J Radiol. 2009;82(984):1000–9. doi:10.1259/bjr/88256274.
Open DOI Search in Google Scholar Back to article
Shoa P, Rahimian J, Jalali R, et al. Visual system complication estimation after craniospinal irradiation. Int J Radiat Res. 2020;18(1):117–23.
Search in Google Scholar Back to article
Faber J, Wingerter A, Neu MA, Hennewig U, Bender HU, Blettner M, et al. Cardiovascular late effects in childhood cancer survivors: The German CVSS study. Eur Heart J. 2018;39(17):1555–62. doi:10.1093/eurheartj/ehx747.
Open DOI Search in Google Scholar Back to article
Braunstein S, Nakamura JL. Radiotherapy-induced malignancies: Review and clinical implications. Front Oncol. 2013;3:73. doi:10.3389/fonc.2013.00073.
Open DOI Search in Google Scholar Back to article

Authors

Metrics

Articles in this issue

DOI: https://doi.org/10.2478/jcas-2026-0006 | Journal eISSN: 2411-989X

Journal RSS Feed

Language: English

Page range: 40 - 45

Published on: Apr 3, 2026

Published by: Shakuat Khanum Memorial Cancer Hospital and Research Centre

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

Craniospinal Irradiation,

Medulloblastoma,

Pediatric malignancy,

Volumetric Arc Modulated Therapy (VMAT),

Related subjects:

Internal medicine, other,

Haematology, oncology,

Pediatrics and juvenile medicine,

Paediatric haematology and oncology,

Surgery,

Surgery, other

© 2026 Muhammad Anas Tahseen Asar, Tabinda Sadaf, Asma Rashid, Aqueel Shahid, Fajar Rafi Ranjha, Raheel Mukhtar, Haniya Rizwan, Ahmad Rashid, published by Shakuat Khanum Memorial Cancer Hospital and Research Centre
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 12 (2026): Issue 1 (March 2026)