Figure 1.
Figure 2.
Figure 3.
Figure 4.
Multivariable cox-regression model for predictors of survival in our cohort
| Variable | Hazard Ratio | 95% Confidence Interval | p value |
|---|---|---|---|
| Age | 1.03 | [0.99 – 1.08] | 0.15 |
| Number of cycles | 0.74 | [0.61 – 0.87] | < 0.01 |
| White cell counts at presentation | 1.00 | [0.99 – 1.01] | 0.89 |
| Presence of cytogenetic abnormalities* | 0.82 | [0.40 – 1.71] | 0.60 |
| Presence of molecular abnormalities* | 0.73 | [0.27 – 2.02] | 0.55 |
Molecular abnormalities identified in our cohort
| Molecular abnormalities | Count |
|---|---|
| FLT 3-ITD | 7 |
| NPM 1 | 4 |
| Others (CALR, U2AF1, KRAS, PHF6) | 4 |
| IDH-1/2 | 3 |
| TP53 | 2 |
| WT-1 | 2 |
| NRAS | 2 |
| TET-2 | 2 |
| RUNX-1 | 2 |
| JAK2 | 2 |
| ASXL-1 | 1 |
Patient characteristics_
| Variable | n (%) or mean ± SD |
|---|---|
| Gender | |
| Male | 45 (77.6) |
| Female | 13 (22.4) |
| Age | 61.5 [55.0 – 67.0] |
| Number of cycles | 4 [2 – 6] |
| White cell counts at presentation | 5.8 [2.4 – 16.1] |
| Outcome | |
| Death | 44 (75.9) |
| Under treatment | 9 (15.5) |
| Palliative care | 1 (1.7) |
| Lost to follow up | 4 (6.9) |
| Secondary leukemia | |
| MDS transformation | 7 (12.1) |
| CMML transformation | 2 (3.4) |
| MF transformation | 2 (3.4) |
| Remission achieved | |
| Yes | 22 (37.9) |
| No | 33 (56.9) |
| Not known | 3 (5.2) |
| Cause of death | |
| Refractory disease | 30 (63.8) |
| Relapsed disease | 10 (21.3) |
| Secondary Cause* | 4 (8.5) |
| Not Known | 3 (6.4) |
| Comorbid conditions | |
| Hypertension | 17 (29.3) |
| Diabetes Mellitus | 20 (34.5) |
| Coronary Artery Disease | 4 (6.9) |
Cytogenetic abnormalities identified in our cohort
| Cytogenetic abnormalities | n (%) |
|---|---|
| Normal | 20 (34) |
| Complex karyotypic abnormalities* | 5 (9) |
| Deletion 7q | 4 (7) |
| Translocation 8:21 | 2 (3) |
| Trisomy 8 | 2 (3) |
| Monosomy X | 2 (3) |
| Deletion 11q | 1 (2) |
| Inversion 16 | 1 (2) |
| Translocation 1:22 | 1 (2) |
| Trisomy 11 | 1 (2) |
| Trisomy 19 | 1 (2) |
| Metaphysis not found | 18 (31) |