Acute Drug-Allergic Tubulointerstitial Nephritis

Daniela Rădulescu

doi:10.2478/inmed-2020-0140

.blurhash-client-img { display: none !important; }

Acute Drug-Allergic Tubulointerstitial Nephritis

Internal Medicine

Volume 17 (2020): Issue 6 (December 2020)

By: Daniela Rădulescu

Open Access

|Jan 2021

Abstract

Acute drug-allergic tubulointerstitial nephrites are increasingly common conditions in current practice due to increased patient access to a variety of drugs. The clinical-biological panel associates acute renal injury with hypersensitivity phenomena. Considered classically reversible after the cessation of the incriminated drug, drug-allergic tubulointerstitial nephrites have changed their evolutionary characteristics in recent decades, even under treatment. This article presents the clinical-biological, therapeutic and evolutionary characteristics of drug-allergic tubulointerstitial nephrites.

References

1. Raghavan R, Shawar S. Mechanisms of Drug-Induced Interstitial Nephritis. Adv Chronic Kidney Dis. 2017; 24(2): 64-71.10.1053/j.ackd.2016.11.00428284381
Search in Google Scholar Back to article
2. Perazella MA. Renal Vulnerability to Drug Toxicity. CJASN. 2009; 4(7): 1275-1283.10.2215/CJN.0205030919520747
Search in Google Scholar Back to article
3. Perazella MA. Drug-induced nephropathy: an update. Expert Opin Drug Saf. 2005; 4(4): 689-706.10.1517/14740338.4.4.68916011448
Search in Google Scholar Back to article
4. Markowitz GS, Perazella MA. Drug-induced renal failure: a focus on tubulointerstitial disease. Clin Chim Acta. 2005; 351(1-2): 31-47.10.1016/j.cccn.2004.09.00515563870
Search in Google Scholar Back to article
5. Rossert J. Drug-induced acute interstitial nephritis. Kidney Int. 2001; 60(2): 804-817.10.1046/j.1523-1755.2001.060002804.x11473672
Search in Google Scholar Back to article
6. Perazella MA, Markowitz GS: Drug-induced acute interstitial nephritis. Nat Rev Nephrol. 2010; 6(8): 461-470.10.1038/nrneph.2010.7120517290
Search in Google Scholar Back to article
7. Wilson DM, Turner DR, Cameron JS, Ogg CS, Brown CB, Chantler C. Value of renal biopsy in acute intrinsic renal failure. Br Med J. 1976; 2(6033): 459-461.10.1136/bmj.2.6033.4591687565953608
Search in Google Scholar Back to article
8. Perazella MA. Diagnosing drug-induced AIN in the hospitalized patient: a challenge for the clinician. Clin Nephrol. 2014; 81(6): 381-388.10.5414/CN108301432685624691017
Search in Google Scholar Back to article
9. Nussbaum EZ, Perazella MA. Diagnosing acute interstitial nephritis: considerations for clinicians. Clin Kidney J. 2019; 12(6): 808-813.
Search in Google Scholar Back to article
10. Nast CC. Medication-Induced Interstitial Nephritis in the 21st Century. Adv Chronic Kidney Dis. 2017; 24(2): 72-79.10.1053/j.ackd.2016.11.01628284382
Search in Google Scholar Back to article
11. Stillman IE Lima EQ Burdmann EA. Renal biopsies in acute kidney injury: who are we missing? Clin J Am Soc Nephrol. 2008; 3(3): 647-648.10.2215/CJN.0111030818385394
Search in Google Scholar Back to article
12. Raghavan R, Eknoyan G. Acute interstitial nephritis -a reappraisal and update. Clin Nephrol. 2014; 82(3): 149-162.10.5414/CN10838
Search in Google Scholar Back to article
13. Farrington K, Levison DA, Greenwood RN, Cattell WR, Baker LR. Renal biopsy in patients with unexplained renal impairment and normal kidney size. Q J Med. 1989; 70(263): 221-233.
Search in Google Scholar Back to article
14. Rossert JA, Fischer EA. Acute Interstitial Nephritis. În: Feehally J, Floege J, Tonelli M, Johnson RJ (editori): Comprehensive Clinical Nephrology, ediţia a 6-a, Elsevier. 2019; pag. 729-737.10.1016/B978-0-323-05876-6.00060-5
Search in Google Scholar Back to article
15. Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, Nasr SH. Biopsy-proven acute interstitial nephritis, 1993-2011: a case series. Am J Kidney Dis. 2014; 64(4): 558-566.10.1053/j.ajkd.2014.04.02724927897
Search in Google Scholar Back to article
16. Moledina DG, Perazella MA. Drug-induced acute interstitial nephritis. Clin J Am Soc Nephrol. 2017; 12(12): 2046-2049.10.2215/CJN.07630717571827928893923
Search in Google Scholar Back to article
17. Praga M, Sevillano A, Auñón P, González E. Changes in the aetiology, clinical presentation and management of acute interstitial nephritis, an increasingly common cause of acute kidney injury. Nephrol Dial Transplant. 2015; 30(9): 1472-1479.10.1093/ndt/gfu32625324356
Search in Google Scholar Back to article
18. Blank ML, Parkin L, Paul C, Herbison P. A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use. Kidney Int. 2014; 86(4): 837-844.10.1038/ki.2014.74418418724646856
Search in Google Scholar Back to article
19. Brewster UC, Perazella MA. Proton pump inhibitors and the kidney: critical review. Clin Nephrol. 2007; 68(2): 65-72.
Search in Google Scholar Back to article
20. Pusey CD, Saltissi D, Bloodworth L, Rainford DJ, Christie JL. Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q J Med. 1983; 52(206): 194-211.
Search in Google Scholar Back to article
21. Nussbaum EZ, Perazella MA. Update on the nephrotoxicity of novel anticancer agents. Clin Nephrol 2018; 89(3): 149-165.10.5414/CN10937129350175
Search in Google Scholar Back to article
22. Perazella MA, Shirali AC. Nephrotoxicity of cancer immunotherapies: past, present and future. J Am Soc Nephrol; 29(8): 2039-2052.10.1681/ASN.2018050488606507929959196
Search in Google Scholar Back to article
23. Airy M, Raghavan R, Truong LD, Eknoyan G. Tubulointerstitial nephritis and cancer chemotherapy: update on a neglected clinical entity. Nephrol Dial Transplant. 2013; 28(10): 2502-2509.10.1093/ndt/gft24124009289
Search in Google Scholar Back to article
24. Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, Nasr SH. Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int. 2015; 87(2): 458-464.10.1038/ki.2014.29425185078
Search in Google Scholar Back to article
25. Neilson EG. Pathogenesis and therapy of interstitial nephritis. Kidney Int. 1989; 35(5): 1257-1270.10.1038/ki.1989.118
Search in Google Scholar Back to article
26. Krishnan N, Perazella MA. Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iran J Kidney Dis. 2015; 9(1): 3-13.
Search in Google Scholar Back to article
27. Galpin JE, Shinaberger JH, Stanley TM, Blumenkrantz MJ, Bayer AS, Friedman GS, Montgomerie JZ, Guze LB, Coburn JW, Glassock RJ. Acute interstitial nephritis due to methicillin. Am J Med. 1978; 65(5): 756-765.10.1016/0002-9343(78)90793-3
Search in Google Scholar Back to article
28. Baldwin DS, Levine BB, McCluskey RT, Gallo GR. Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med. 1968; 279(23): 1245-1252.10.1056/NEJM196812052792302
Search in Google Scholar Back to article
29. Schubert C, Bates WD, Moosa MR. Acute tubulointerstitial nephritis related to antituberculous drug therapy. Clin Nephrol. 2010; 73(6): 413-.10.5414/CNP73413
Search in Google Scholar Back to article
30. Praga M, Appel GB. Clinical manifestations and diagnosis of acute interstitial nephritis. UPTODATE 2018. Disponibil la: https://www.uptodate.com, accesat aprilie 2020.
Search in Google Scholar Back to article
31. Ten RM, Torres VE, Milliner DS, Schwab TR, Holley KE, Gleich GJ. Acute interstitial nephritis: immunologic and clinical aspects. Mayo Clin Proc. 1988; 63(9): 921-930.10.1016/S0025-6196(12)62697-4
Search in Google Scholar Back to article
32. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984; 310(9): 563-572.10.1056/NEJM1984030131009056363936
Search in Google Scholar Back to article
33. Belliere J, Meyer N, Mazieres J, Ollier S, Boulinguez S, Delas A, Ribes D, Faguer S. Acute interstitial nephritis related to immune checkpoint inhibitors. Br J Cancer. 2016; 115(12): 1457-146.10.1038/bjc.2016.358515535827832664
Search in Google Scholar Back to article
34. Baker RJ, Pusey CD. The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant. 2004; 19(1): 8-11.10.1093/ndt/gfg46414671029
Search in Google Scholar Back to article
35. Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003; 67(12): 2527-2534.
Search in Google Scholar Back to article
36. Praga M, González E. Acute interstitial nephritis. Kidney Int. 2010; 77(11): 956-961.10.1038/ki.2010.8920336051
Search in Google Scholar Back to article
37. Saha H, Mustonen J, Helin H, Pasternack A. Limited value of the fractional excretion of sodium test in the diagnosis of acute renal failure. Nephrol Dial Transplant. 1987; 2(2): 79-82.
Search in Google Scholar Back to article
38. Muriithi AK, Nasr SH, Leung N. Utility of urine eosinophils in the diagnosis of acute interstitial nephritis. Clin J Am Soc Nephrol. 2013; 8(11):1857-1862.10.2215/CJN.01330213381789824052222
Search in Google Scholar Back to article
39. Espejo B, Herrero JC, Torres A, Martínez A, Gutiérrez E, Morales E, González E, Bueno B, Valentín MO, Praga M. Immunoallergic interstitial nephritis vs. cholesterol atheroembolism. Differentiating characteristics. Nefrologia. 2003; 23(2): 125-130.
Search in Google Scholar Back to article
40. Hiraoka M Hori C Tsuchida S Tsukahara H Sudo M Ultrasonographic findings of acute tubulointerstitial nephritis. Am J Nephrol. 1996; 16(2): 154-158.10.1159/000168989
Search in Google Scholar Back to article
41. Linton AL, Richmond JM, Clark WF, et al. Gallium67 scintigraphy in the diagnosis of acute renal disease. Clin Nephrol. 1985; 24(2): 84-87.
Search in Google Scholar Back to article
42. Koselj M Kveder R Bren AF Rott T Acute renal failure in patients with drug-induced acute interstitial nephritis. Ren Fail. 1993; 15(1): 69-72.10.3109/08860229309065575
Search in Google Scholar Back to article
43. Graham F, Lord M, Froment D, Cardinal H, Bollée G. The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis. Clin Kidney J. 2016; 9(1): 76-81.10.1093/ckj/sfv129
Search in Google Scholar Back to article
44. Eknoyan G Raghavan R Acute tubulointerstitial nephritis. În: Coffman T, Falk R, Molitoris B, Neilson E, Schrier RW (editori). Schrier’s Diseases of the Kidney. Ediţia a 9-a. Philadelphia, PA: Lippincott, Williams&Wilkins. 2013; pag.994-1017.
Search in Google Scholar Back to article
45. Schwarz A, Krause PH, Kunzendorf U, Keller F, Distler A. The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis. Clin Nephrol. 2000; 54(3): 179-190.
Search in Google Scholar Back to article
46. Fernandez-Juarez G, Perez JV, Caravaca-Fontán F, Quintana L, Shabaka A, Rodriguez E, Gadola L, de Lorenzo A, Cobo MA, Oliet A, Sierra M, Cobelo C, Iglesias E, Blasco M, Galeano C, Cordon A, Oliva J, Praga M, Spanish Group for the Study of Glomerular Diseases (GLOSEN). Duration of treatment with corticosteroids and recovery of kidney function in acute interstitial nephritis. Clin J Am Soc Nephrol. 2018; 13(12): 1851-1858.10.2215/CJN.01390118
Search in Google Scholar Back to article
47. Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB. Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol. 2006; 1(4): 718-722.10.2215/CJN.01711105
Search in Google Scholar Back to article
48. Forgacs I, Loganayagam A. Overprescribing proton pump inhibitors. BMJ. 2008; 336(7634): 2-3.10.1136/bmj.39406.449456.BE
Search in Google Scholar Back to article
49. Ruffenach SJ, Siskind MS, Lien YH. Acute interstitial nephritis due to omeprazole. Am J Med. 1992; 93(4): 472-473.10.1016/0002-9343(92)90181-A
Search in Google Scholar Back to article
50. Torpey N, Barker T, Ross C. Drug-induced tubulointerstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit. Nephrol Dial Transplant. 2004; 19(6): 1441-1446.10.1093/ndt/gfh13715004262
Search in Google Scholar Back to article
51. Geevasinga N, Kairaitis L, Rangan GK, Coleman PL. Acute interstitial nephritis secondary to esomeprazole. Med J Aust. 2005; 182(5): 235-236.10.5694/j.1326-5377.2005.tb06675.x15748135
Search in Google Scholar Back to article
52. Geevasinga N, Coleman PL, Roger SD. Rabeprazole-induced acute interstitial nephritis. Nephrology (Carlton). 2005; 10(1): 7-9.10.1111/j.1440-1797.2005.00365.x15705174
Search in Google Scholar Back to article
53. Klassen S, Krepinsky JC, Prebtani AP. Pantoprazole-induced acute interstitial nephritis. CMAJ. 2013; 185(1): 56-59.10.1503/cmaj.120954353778023109611
Search in Google Scholar Back to article
54. Moledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. J Nephrol. 2016; 29(5): 611-616.10.1007/s40620-016-0309-227072818
Search in Google Scholar Back to article
55. Sampathkumar K, Ramalingam R, Prabakar A, Abraham A. Acute interstitial nephritis due to proton pump inhibitors. Indian J Nephrol. 2013; 23(4): 304-307.10.4103/0971-4065.114487374197923960351
Search in Google Scholar Back to article
56. Antoniou T, Macdonald EM, Hollands S, Gomes T, Mamdani MM, Garg AX, Paterson M, Juurlink DN. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJO. 2015; 3(2): E166-E171.10.9778/cmajo.20140074457183026389094
Search in Google Scholar Back to article
57. Simpson IJ, Marshall MR, Pilmore H, Manley P, Williams L, Thein H, Voss D. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology (Carlton). 2006; 11(5): 381-385.10.1111/j.1440-1797.2006.00651.x17014549
Search in Google Scholar Back to article
58. Geevasinga N, Coleman PL, Webster AC, Roger SD. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol. 2006; 4(5): 597-604.10.1016/j.cgh.2005.11.00416630752
Search in Google Scholar Back to article
59. Morschel CF, Mafra D, Eduardo JCC. The relationship between proton pump inhibitors and renal disease. J Bras Nefrol. 2018; 40(3): 301-306.10.1590/2175-8239-jbn-2018-0021653396030010692
Search in Google Scholar Back to article
60. Ball S, Cook T, Hulme B, Palmer A, Taube D. The diagnosis and racial origin of 394 patients undergoing renal biopsy: An association between Indian race and interstitial nephritis. Nephrol Dial Transplant. 1997; 12(1): 71-77.10.1093/ndt/12.1.719027776
Search in Google Scholar Back to article
61. Manika K, Tasiopoulou K, Vlogiaris L, Lada M, Papaemmanouil S, Zarogoulidis K, Kioumis I. Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication. Ren Fail. 2013; 35(8): 1179-1181.10.3109/0886022X.2013.81556723883374
Search in Google Scholar Back to article
62. De Vriese AS, Robbrecht DL, Vanholder RC, Vogelaers DP, Lameire NH. Rifampicin-associated acute renal failure: pathophysiologic, immunologic, and clinical features. Am J Kidney Dis. 1998; 31(1): 108-115.10.1053/ajkd.1998.v31.pm94284609428460
Search in Google Scholar Back to article
63. Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA. Acute renal failure due to rifampicin: a study of 25 patients. Am J kidney Dis. 2002; 14(4): 690-696.10.1053/ajkd.2002.3567512324902
Search in Google Scholar Back to article
64. Ortiz A, Barat A, Oliva H. Acute kidney failure induced by rifampicin. Nefrologia. 2001; 21(1): 92-94.
Search in Google Scholar Back to article
65. Min HK, Kim EO, Lee SJ, Chang YK, Suh KS, Yang CW, Kim SY, Hwang HS. Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis. BMC Nephrol. 2013; 14:13.10.1186/1471-2369-14-13355835123320835
Search in Google Scholar Back to article
66. Alper AB Jr, Meleg-Smith S, Krane NK. Nephrotic syndrome and interstitial nephritis associated with celecoxib. Am J Kidney Dis. 2002; 40(5): 1086-1090.10.1053/ajkd.2002.3634912407655
Search in Google Scholar Back to article
67. Andrews PA, Sampson SA. Topical non-steroidal drugs are systemically absorbed and may cause renal disease. Nephrol Dial Transplant. 1999; 14(1): 187-189.10.1093/ndt/14.1.18710052505
Search in Google Scholar Back to article
68. Krummel T, Dimitrov Y, Moulin B, Hannedouche T. Drug points: Acute renal failure induced by topical ketoprofen. BMJ. 2000; 320(7227): 93.10.1136/bmj.320.7227.932725610625264
Search in Google Scholar Back to article
69. Kikuchi H, Aoyagi M, Nagahama K, Yajima Y, Yamamura Co, Arai Y, Hirasawa S, Aki S, Inaba N, Tanaka H, Tamura T. Case Report: Nephrotic-range Proteinuria and Interstitial Nephritis Associated with the Use of a Topical Loxoprofen Patch. Intern Med. 2014; 53(11): 1131-1135.10.2169/internalmedicine.53.166924881736
Search in Google Scholar Back to article
70. Lucas GNC, Leitão ACC, Alencar RL, Xavier RMF, Daher EF, Silva Junior GBD. Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. J Bras Nefrol. 2019; 41(1): 124-130.10.1590/2175-8239-jbn-2018-0107
Search in Google Scholar Back to article
71. Jung JH, Kang KP, Kim W, Park SK, Lee S. Nonsteroidal antiinflammatory drug induced acute granulomatous interstitial nephritis. BMC Res Notes. 2015; 8:793.10.1186/s13104-015-1788-2468114226674186
Search in Google Scholar Back to article
72. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984; 310(9): 563-572.10.1056/NEJM1984030131009056363936
Search in Google Scholar Back to article
73. Mohammed EP, Stevens JM. Recurrence of Arthrotec-associated nephrotic syndrome with re-challenge. Clin Nephrol. 2000; 53(6): 483-485.
Search in Google Scholar Back to article
74. Ejaz P, Bhojani K, Joshi VR. NSAIDs and Kidney. JAPI. 2004; 52: 632-640.
Search in Google Scholar Back to article
75. Nawaz FA, Larsen CP, Troxell ML. Membranous Nephropathy and Nonsteroidal Anti-inflammatory Agents. AJKD. Kidney Biopsy Teaching Case. 2013; 62(5): 1012-1017.
Search in Google Scholar Back to article
76. Feinfeld DA, Olesnicky L, Pirani CL, Appel GB. Nephrotic syndrome associated with use of the nonsteroidal anti-inflammatory drugs. Case report and review of the literature. Nephron. 1984; 37(3): 174-179.10.1159/0001832396738768
Search in Google Scholar Back to article
77. Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013; 16(5): 821-847.10.18433/J3VW2F
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/inmed-2020-0140 | Journal eISSN: 1220-5818 | Journal ISSN: 1220-5818

Journal RSS Feed

Language: English

Page range: 25 - 35

Published on: Jan 29, 2021

Published by: Romanian Society of Internal Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

acute tubulointerstitial nephritis,

drugs,

hypersensitivity,

tubulointerstitial inflammation,

Related subjects:

Internal medicine, other,

Cardiology,

Gastroenterology,

Pneumology

© 2021 Daniela Rădulescu, published by Romanian Society of Internal Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 17 (2020): Issue 6 (December 2020)