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An update on the LAN blood group system Cover

An update on the LAN blood group system

By: Lilian Castilho  
Paid access
|Mar 2025

References

  1. Peyrard T. The LAN blood group system: a review. Immunohematology 2013;29:131–5.
  2. Storry JR, Castilho L, Daniels G, et al. International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology: Cancun report (2012). Vox Sang 2014;107:90–6.
  3. Brooks S, Squires JE. Hemolytic disease of the fetus and newborn caused by anti-Lan. Transfusion 2014;54:1317–20.
  4. Tanaka M, Yamamuro Y, Takahashi J, et al. Novel alleles of Lan− in Japanese populations. Transfusion 2014;54:1438–9.
  5. Haer-Wigman L, Soussan AA, Ligthart P, et al. Molecular analysis of immunized Jr(a–) or Lan– patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a–) and Lan– phenotypes. Transfusion 2014;54:1836–46.
  6. Schoeman EM, Roulis EV, Liew Y-W, et al. Targeted exome sequencing defines novel and rare variants in complex blood group serology cases for a red blood cell reference laboratory setting. Transfusion 2018;58:284–93.
  7. Yamamuro Y, Isa K, Ogasawara K, et al. The mutations of ABCB6 gene in Japanese blood donors with weak expression of Lan antigen. Vox Sang 2014;107:186–7.
  8. Karamatic Crew V, Jones B, McNeill A, et al. Two Lan null individuals with a novel ABCB6 null alleles and a compound heterozygote with a rare combination of known null and weak ABCB6 alleles. Vox Sang 2019:114:191–2.
  9. Andolfo I, Russo R, Manna F, et al. Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia. Haematologica 2016;101:909–17.
  10. Egan ES, Weekes M, Kanjee U, et al. Erythrocytes lacking the Langeries blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol 2018:1:45. doi: 10.1038/s42003-018-0046-2.
  11. Sharma P, Manthri S, Patterson E, et al. Anti-Lan antibodies: a rare etiology of severe blood transfusion reaction. Cureus 2020;12:e10832. doi: 10.7759/cureus.10832.
DOI: https://doi.org/10.2478/immunohematology-2025-005 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 17 - 19
Published on: Mar 26, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Lilian Castilho, published by American National Red Cross
This work is licensed under the Creative Commons License.