An update on the LAN blood group system

Castilho, Lilian

doi:10.2478/immunohematology-2025-005

Abstract

This update on the LAN blood group system (Peyrard T. A review of the Lan blood group system. Immunohematology 2013; 29:131–5) reports new ABCB6 alleles encoding Lan– and Lan(+^wk) phenotypes and new functional aspects of the ABCB6 glycoprotein. The L AN blood group system (International Society of Blood Transfusion system 33) consists of one antigen: Lan.

References

Peyrard T. The LAN blood group system: a review. Immunohematology 2013;29:131–5.
Search in Google Scholar Back to article
Storry JR, Castilho L, Daniels G, et al. International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology: Cancun report (2012). Vox Sang 2014;107:90–6.
Search in Google Scholar Back to article
Brooks S, Squires JE. Hemolytic disease of the fetus and newborn caused by anti-Lan. Transfusion 2014;54:1317–20.
Search in Google Scholar Back to article
Tanaka M, Yamamuro Y, Takahashi J, et al. Novel alleles of Lan− in Japanese populations. Transfusion 2014;54:1438–9.
Search in Google Scholar Back to article
Haer-Wigman L, Soussan AA, Ligthart P, et al. Molecular analysis of immunized Jr(a–) or Lan– patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a–) and Lan– phenotypes. Transfusion 2014;54:1836–46.
Search in Google Scholar Back to article
Schoeman EM, Roulis EV, Liew Y-W, et al. Targeted exome sequencing defines novel and rare variants in complex blood group serology cases for a red blood cell reference laboratory setting. Transfusion 2018;58:284–93.
Search in Google Scholar Back to article
Yamamuro Y, Isa K, Ogasawara K, et al. The mutations of ABCB6 gene in Japanese blood donors with weak expression of Lan antigen. Vox Sang 2014;107:186–7.
Search in Google Scholar Back to article
Karamatic Crew V, Jones B, McNeill A, et al. Two Lan null individuals with a novel ABCB6 null alleles and a compound heterozygote with a rare combination of known null and weak ABCB6 alleles. Vox Sang 2019:114:191–2.
Search in Google Scholar Back to article
Andolfo I, Russo R, Manna F, et al. Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia. Haematologica 2016;101:909–17.
Search in Google Scholar Back to article
Egan ES, Weekes M, Kanjee U, et al. Erythrocytes lacking the Langeries blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol 2018:1:45. doi: 10.1038/s42003-018-0046-2.
Search in Google Scholar Back to article
Sharma P, Manthri S, Patterson E, et al. Anti-Lan antibodies: a rare etiology of severe blood transfusion reaction. Cureus 2020;12:e10832. doi: 10.7759/cureus.10832.
Search in Google Scholar Back to article

An update on the LAN blood group system

Abstract

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