Evaluation of the anthelmintic effectiveness of Cinnamomum verum bark extract in mice naturally infected with Aspiculuris tetraptera: in vitro and in vivo
References
- Alimi, D., Hajri, A., Jallouli, S., Sebai, H. (2021): <em>In vitro</em> acaricidal activity of essential oil and crude extracts of <em>Laurus nobilis</em>, (Lauraceae) grown in Tunisia, against arthropod ectoparasites of livestock and poultry: <em>Hyalomma scupense</em> and <em>Dermanyssus gallinae. Vet Parasitol</em>, 298: 109507. DOI: <a href="https://doi.org/10.1016/j.vetpar.2021.109507" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.vetpar.2021.109507</a>
- Amirmohammadi, M., Khajoenia, S., Bahmani, M., Rafieian-Kopaei, M., Eftekhari, Z., Qorbani, M. (2014): <em>In vivo</em> evaluation of antiparasitic effects of <em>Artemisia abrotanum</em> and <em>Salvia officinalis</em> extracts on <em>Syphacia obvelata, Aspiculoris tetrapetra</em> and <em>Hymenolepis nana</em> parasites. <em>Asian Pac J Trop Dis</em>, 4(Suppl 1): S250 – S254. DOI: <a href="https://doi.org/10.1016/S2222-1808(14)60449-7" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/S2222-1808(14)60449-7</a>
- Bagheri, E., Shori, A.B, Peng, C.W., Baba, A.S., Alzahrani, A.J. (2024): Phytochemical analysis and medicinal properties of some selected traditional medicinal plants. <em>Int J Agric Biosci</em>, 13(4): 689 – 700. DOI: <a href="https://doi.org/10.47278/journal.ijab/2024.177" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.47278/journal.ijab/2024.177</a>
- Beshbishy, M., Batiha, G. S., Adeyemi, S., Yokoyama, N., Igarashi, I. (2019): Inhibitory effects of methanolic <em>Olea europaea</em> and acetonic <em>Acacia laeta</em> on growth of <em>Babesia</em> and <em>Theileria. Asian Pac J Trop Med</em>, 12: 425 – 434. DOI: <a href="https://doi.org/10.4103/1995-7645.267586" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.4103/1995-7645.267586</a>
- Bruno, R., Maresca, M., Canaan, S., Cavalier, J.F., Mabrouk, K., Boidin-Wichlacz, C., Tasiemski, A. (2019): Worms’ antimicrobial peptides. <em>Mar Drugs</em>, 17(9): 512. DOI: <a href="https://doi.org/10.3390/md17090512" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/md17090512</a>
- Caputo, L., Nazzaro, F., Souza, L.F., Aliberti, L., De Martino, L., Fratianni, F., De Feo, V. (2017): <em>Laurus nobilis</em>: Composition of essential oil and its biological activities. <em>Molecules</em>, 22(6): 930. DOI: <a href="https://doi.org/10.3390/molecules22060930" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/molecules22060930</a>
- Catani, L., Manachini, B., Grassi, E., Guidi, L., Semprucci, F. (2023): Essential oils as nematicides in plant protection - A review. <em>Plants</em>, 12(6): 1418. DOI: <a href="https://doi.org/10.3390/plants12061418" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/plants12061418</a>
- Falcón-Ordaz, J., Pulido-Flores, G., Monks, S. (2010): Una nueva especie de <em>Aspiculuris</em> (Nematoda: Heteroxynematidae), parásito de <em>Mus musculus</em> (Rodentia: Muridae), de Hidalgo, México [New species of <em>Aspiculuris</em> (Nematoda: Heteroxynematidae), parasite of <em>Mus musculus</em> (Rodentia: Muridae), from Hidalgo, Mexico]. <em>Rev Mex Biodivers</em>, 81(3): 669 – 676 (In Spanish)
- Fanelli, E., Vovlas, A., D’addabbo, T., De Luca, F. (2025): Molecular mechanism of <em>Cinnamomum zeylanicum</em> and <em>Citrus aurantium</em> essential oils against the root-knot nematode, <em>Meloidogyne incognita. Sci Rep</em>,15(1): 6077. DOI:<a href="https://doi.org/10.1038/s41598-025-90529-8" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1038/s41598-025-90529-8</a>
- Fernandez, C.M., Da Rosa, M.F., Fernandez, A.M., Bortolucci, W.C., Ferreira, F.P., Linde, G.A., Gazim, Z.C. (2020): Essential oil and fractions isolated of Laurel to control adults and larvae of cattle ticks. <em>Nat Prod Res</em>, 34(5): 731 – 735. DOI: <a href="https://doi.org/10.1080/14786419.2018.1495637" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1080/14786419.2018.1495637</a>
- Gerwin, P.M., Ricart Arbona, R.J., Riedel, E.R., Lepherd, M.L., Henderson, K.S., Lipman, N.S. (2017): Evaluation of traditional and contemporary methods for detecting <em>Syphacia obvelata</em> and <em>Aspiculuris tetraptera</em> in laboratory mice. <em>J Am Assoc Lab Anim Sci</em>, 56(1): 32 – 41
- Hassan, N.F., El-Shemy, A., El-Ezz, N.A., Allam, A.M., El-Shanawany, E.E. (2024): Intensity of gastrointestinal parasites and the associated risk factors, and sero-prevalence of hemonchosis among camels in Egypt. <em>Int J Vet Sci</em>, 13(5): 667 – 676. DOI: <a href="https://doi.org/10.47278/journal.ijvs/2024.157" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.47278/journal.ijvs/2024.157</a>
- Hegazy, S.A., Abd Elmawla, S.M., Khorshed, M.M,. Salem, F.A. (2023): Productive and immunological performance of small ruminants offered some medicinal plants as feed additives. <em>Int J Vet Sci</em>, 12: 120 – 125. DOI: <a href="https://doi.org/10.47278/journal.ijvs/2022.163" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.47278/journal.ijvs/2022.163</a>
- Hernando, G., Turani, O., Bouzat, C. (2019): Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity. <em>PLoS Negl Trop Dis</em>, 13(11): e0007895. DOI: <a href="https://doi.org/10.1371/journal.pntd.0007895" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1371/journal.pntd.0007895</a>
- Hernando, G., Turani, O., Rodriguez Araujo, N., Pulido Carras-quero, A., Bouzat, C. (2025): Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil. <em>Sci Rep</em>, 15: 5422. DOI: <a href="https://doi.org/10.1038/s41598-025-89883-4" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1038/s41598-025-89883-4</a>
- Idris, O.A., Wintola, O.A., Afolayan, A.J. (2019): Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment. <em>Heliyon</em>, 5(1): e01161. DOI: <a href="https://doi.org/10.1016/j.heliyon.2019.e01161" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.heliyon.2019.e01161</a>
- Jemâa, J.B., Tersim, N., Toudert, K.T., Khouja, M.L. (2012): Insecticidal activities of essential oils from leaves of <em>Laurus nobilis</em> L. from Tunisia, Algeria and Morocco, and comparative chemical composition. <em>J Stored Prod Res</em>, 48: 97 – 104. DOI: <a href="https://doi.org/10.1016/j." target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.</a> jspr.2011.10.003
- Weinstock, J.V., Elliott, D.E. (2009): Helminths and the IBD hygiene hypothesis. <em>Inflamm Bowel Dis</em>, 15(1): 128 – 133. DOI: <a href="https://doi.org/10.1002/ibd.20633" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1002/ibd.20633</a>
- Kasl, E.L., Font, W.F., Criscione, C.D. (2018): Resolving evolutionary changes in parasite life cycle complexity: Molecular phylogeny of the trematode genus <em>Alloglossidium</em> indicates more than one origin of precociousness. <em>Mol Phylogenet Evol</em>, 126: 371 – 381. DOI: <a href="https://doi.org/10.1016/j.ympev.2018.04.027" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.ympev.2018.04.027</a>
- Kivçak, B, Mert, T. (2002): Preliminary evaluation of cytotoxic properties of <em>Laurus nobilis</em> leaf extracts. <em>Fitoterapia</em>, 73(3): 242 – 243. DOI: <a href="https://doi.org/10.1016/s0367-326x(02)00060-6" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/s0367-326x(02)00060-6</a>
- Koike, A., Barreira, J.C., Barros, L., Santos-Buelga, C., Villavicencio, A.L., Ferreira, I.C. (2015): Edible flowers of <em>Viola tricolor</em> L. as a new functional food: Antioxidant activity, individual phenolics and effects of gamma and electron-beam irradiation. <em>Food Chem</em>, 179: 6 – 14. DOI: <a href="https://doi.org/10.1016/j.foodchem.2015.01.123" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.foodchem.2015.01.123</a>
- Manikandan, P., Letchoumy, P.V., Gopalakrishnan, M., Nagini, S. (2008): Evaluation of <em>Azadirachta indica</em> leaf fractions for <em>in vitro</em> antioxidant potential and <em>in vivo</em> modulation of biomarkers of chemoprevention in the hamster buccal pouch carcinogenesis model. <em>Food Chem Toxicol</em>, 46(7): 2332 – 2343. DOI: <a href="https://doi.org/10.1016/j." target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.</a> fct.2008.03.013
- Matte, E.C., Luciano, F.B., Evangelista, A.G. (2023): Essential oils and essential oil compounds in animal production as antimicrobials and anthelmintics: an updated review. <em>Anim Health Res Rev</em>, 24(1): 1 – 11. DOI: <a href="https://doi.org/10.1017/S1466252322000093" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1017/S1466252322000093</a>
- Merghni, A., Marzouki, H., Hentati, H., Aouni, M., Mastouri, M. (2016): Antibacterial and antibiofilm activities of <em>Laurus nobilis</em> L. essential oil against <em>Staphylococcus aureus</em> strains associated with oral infections. <em>Curr Res Transl Med</em>, 64(1): 29 – 34. DOI: <a href="https://doi.org/10.1016/j.patbio.2015.10.003" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.patbio.2015.10.003</a>
- Nalule, A.S., Mbaria, J.M., Kimenju, J.W. (2013): <em>In vitro</em> anthelmintic potential and phytochemical composition of ethanolic and water crude extracts of <em>Euphorbia heterophylla</em> Linn. <em>J. Med. Plants Res</em>., 7(43): 3202 – 3210
- Oliveira, L.B., Bevilaqua, C.M.L., Costa, C.C., Macedo, I.F., Barros, R.S., Rodrigues, A.M., Navarro, A.C. (2009): Anthelmintic activity of <em>Cocos nucifera</em> L. against sheep gastrointestinal nematodes. <em>Vet Parasitol</em>, 159(1): 55 – 59. DOI: <a href="https://doi.org/10.1016/j.vetpar.2008.10.018" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.vetpar.2008.10.018</a>
- Omer, S.A., Alghamdi, J.M., Alrajeh, A.H., Aldamigh, M., Mohammed, O.B. (2020): Morphological and molecular characterization of <em>Aspiculuris tetraptera</em> (nematoda: Heteroxynematidae) from <em>Mus musculus</em> (rodentia: Muridae) in Saudi Arabia. <em>Biosci Rep</em>, 40(12): BSR20203265. DOI: <a href="https://doi.org/10.1042/BSR20203265" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1042/BSR20203265</a>
- Paparella, A., Nawade, B., Shaltiel-Harpaz, L., Ibdah, M. (2022): A review of the botany, volatile composition, biochemical and molecular aspects, and traditional uses of <em>Laurus nobilis. Plants</em>, 11(9): 1209. DOI: <a href="https://doi.org/10.3390/plants11091209" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/plants11091209</a>
- Ranasinghe, S., Armson, A., Lymbery, A.J., Zahedi, A., Ash, A. (2023): Medicinal plants as a source of antiparasitics: an overview of experimental studies. <em>Pathog Glob Health</em>, 117(6): 535 – 553. DOI: <a href="https://doi.org/10.1080/20477724.2023.2179454" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1080/20477724.2023.2179454</a>
- Sayed, E., Altilmisani, N.M., Albishri, F., Ahmed, A., Elkhalifa, S.M., Al-Dubai, T.A., Al-Wesabi, E.O., (2024): Prevalence and zoonotic potential of parasites in wild rats in Jeddah City, Saudi Arabia. <em>Int J Vet Sci</em>, 13(2): 232 – 240. DOI: <a href="https://doi.org/10.47278/journal.ijvs/2023.091" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.47278/journal.ijvs/2023.091</a>
- Scantlebury, M., Waterman, J.M., Hillegass, M., Speakman, J.R., Bennett, N.C. (2007): Energetic costs of parasitism in the Cape ground squirrel <em>Xerus inauris. Proc Biol Sci</em>, 274(1622): 2169 – 2177. DOI: <a href="https://doi.org/10.1098/rspb.2007.0690" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1098/rspb.2007.0690</a>
- Sebai, E., Abidi, A., Benyedem, H., Dhibi, M., Hammemi, I., Akkari, H. (2022): Phytochemical profile and anthelmintic effects of <em>Laurus nobilis</em> essential oil against the ovine nematode <em>Haemonchus contortus</em> and the murine helminth model <em>Heligmosomoides polygyrus. Vet Parasitol</em>, 312: 109835. DOI: <a href="https://doi.org/10.1016/j.vetpar.2022.109835" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.vetpar.2022.109835</a>
- Simić, A., Soković, M.D., Ristić, M., Grujić-JovAnović, S., vukojević, J., Marin, P.D. (2004): The chemical composition of some Lauraceae essential oils and their antifungal activities. <em>Phytother Res</em>, 18(9): 713 – 717. DOI: <a href="https://doi.org/10.1002/ptr.1516" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1002/ptr.1516</a>
- Siriken, B., Yavuz, C., Guler, A. (2018): Antibacterial Activity of <em>Laurus nobilis</em>: A review of literature. <em>Med. Sci. Discov</em>., 5(11): 374 – 379. DOI: <a href="https://doi.org/10.36472/msd.v5i11.249" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.36472/msd.v5i11.249</a>
- Stepek, G., Buttle, D.J., Duce, I.R., Lowe, A., Behnke, J.M. (2005): Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, <em>Heligmosomoides polygyrus, in vitro. Parasitology</em>, 130(2): 203 – 211. DOI: <a href="https://doi.org/10.1017/s0031182004006225" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1017/s0031182004006225</a>
- Stepek, G., Lowe, A.E., Buttle, D.J., Duce, I.R., Behnke, J.M. (2006): <em>In vitro</em> and <em>in vivo</em> anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, <em>Trichuris muris. Parasitology</em>, 132(5): 681 – 689. DOI: <a href="https://doi.org/10.1017/S003118200500973X" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1017/S003118200500973X</a>
- Mares, M.M., Murshed, M., Aljawdah, H., Al-Quraishy, S. (2024): The assessment of the anthelmintic activity of <em>Laurus nobilis</em> extract in mice naturally infected with <em>Aspiculuris tetraptera. Indian J Anim Res</em>, 58(1): 79 – 88. DOI: <a href="https://doi.org/10.18805/IJAR.BF-1693" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.18805/IJAR.BF-1693</a>
- Yang, F., Long, E., Wen, J., Cao, L., Zhu, C., Hu, H., Lv, Z. (2014): Linalool, derived from <em>Cinnamomum camphora</em> (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of <em>Schistosoma japonicum. Parasit Vectors</em>, 7: 407. DOI: <a href="https://doi.org/10.1186/1756-3305-7-407" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1186/1756-3305-7-407</a>
- Verdú, J.R., Cortez, V., Rosa-Garcia, R., Ortiz, A.J., García-Prieto, U., Lumaret, J.P., Sánchez-Pinero, F. (2023): Nontoxic effects of thymol, carvacrol, cinnamaldehyde, and garlic oil on dung beetles: A potential alternative to ecotoxic anthelmintics. <em>PLoS One</em>, 18(12): e0295753. DOI: <a href="https://doi.org/10.1371/journal.pone.0295753" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1371/journal.pone.0295753</a>
- Williams, A.R., Ramsay, A., Hansen, T.V., Ropiak, H.M., Mejer, H., Nejsum, P., Mueller-Harvey, I. Thamsborg, S.M. (2015): Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (<em>Cinnamomum verum</em>). <em>Sci Rep</em>, 30(5): 14791. DOI: <a href="https://doi.org/10.1038/srep14791" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1038/srep14791</a>
Language: English
Page range: 102 - 110
Submitted on: May 17, 2024
Accepted on: May 25, 2025
Published on: Sep 30, 2025
Published by: Slovak Academy of Sciences
In partnership with: Paradigm Publishing Services
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© 2025 M. Murshed, H. Alzaylaee, M. M. Mares, H. M. A. Aljawdah, S. Al-Quraishy, published by Slovak Academy of Sciences
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