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Studies on the significance of secretory IgA antibodies in the pathogenesis and clinical course of enterobiasis in infected persons from Bulgaria: preliminary findings Cover

Studies on the significance of secretory IgA antibodies in the pathogenesis and clinical course of enterobiasis in infected persons from Bulgaria: preliminary findings

Open Access
|Dec 2024

Figures & Tables

Fig. 1.

Distribution of secretory IgA values in clinically healthy controls by age group, gender, and the reference range of the diagnostic kit used.
Distribution of secretory IgA values in clinically healthy controls by age group, gender, and the reference range of the diagnostic kit used.

Fig. 2.

Distribution of secretory IgA values in persons with enterobiasis by age group, gender, and reference range of the diagnostic kit used.
Distribution of secretory IgA values in persons with enterobiasis by age group, gender, and reference range of the diagnostic kit used.

Fig. 3.

Concentrations of the fecal secretory IgA antibodies in healthy individuals and patients with enterobiasis. To establish statistically significant differences in the values of SIgA, a Mann-Whitney test was performed (exact P value = 0.4991).
Concentrations of the fecal secretory IgA antibodies in healthy individuals and patients with enterobiasis. To establish statistically significant differences in the values of SIgA, a Mann-Whitney test was performed (exact P value = 0.4991).

Demographic data and SIgA levels in both groups studied: infected and non-infected

Examined personswithout evidence of enterobiasis and/or other intestinal parasitic infectionwith laboratory-confirmed enterobiasis


Children & adolescentsAdultsMaleFemaleChildren & adolescentsAdultsMaleFemale


No34619219754656

SIgA values (µg/ml)
Minimum27.5027.5027.5027.5027.5037.5027.5027.50
Maximum899913578999483913916981.5139169704
Range897113308971481113889944.0138899676
Mean1978474,3206014731815481.719011625
Std. Deviation2162608.5256115182562398.227742300
Lower 95% CI of mean1223−164.3825.8782.51299−12.8410781009
Upper 95% CI of mean27321113329521642331976.127252241

Mann Whitney testexact P value = 0.0295*exact P value = 0.5915exact P value = 0.2808exact P value = 0.4568

Mean values of intestinal SIgA concentrations in the studied children, relative to the reported clinical symptom_

NoSIgA mean value (μg/ml)Std. DeviationSIgA min. value (μg/ml)SIgA max. value (μg/ml)
Asymptomatic persons611 588.54204627.59 422.44

Patients with symptoms:362 198.74325427.513 916.00

  perianal itching173 559.54394927.513 916.00
   abdominal pain101 383.66249327.58 064.51
   diarrhea5545.5365427.51 488.38
   bruxism3556.25N/A137.50813.75
   eosinophilia1409.40366409.40409.40

ANOVA test, P value = 0.049
DOI: https://doi.org/10.2478/helm-2024-0034 | Journal eISSN: 1336-9083 | Journal ISSN: 0440-6605
Language: English
Page range: 277 - 285
Submitted on: Aug 23, 2024
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Accepted on: Nov 28, 2024
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Published on: Dec 31, 2024
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2024 E. Kaneva, R. Harizanov, D. Velcheva, N. Tsvetkova, M. Pavlova, I. Alexiev, R. Dimitrova, M. Videnova, R. Borisova, A. Ivanova, published by Slovak Academy of Sciences, Institute of Parasitology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.