Strongyloides stercoralis infection in Ethiopia: systematic review and meta-analysis on prevalence and diagnostic methods

Hailu, T.; Nibret, E.; Amor, A.; Munshea, A.

doi:10.2478/helm-2021-0010

Figures & Tables

Overview of search methods of the articles with inclusion and exclusion criteria.

Front plot of the prevalence of S. stercoralis in Ethiopia using random effect model.

Detection of the bias of the studies conducted using publication bias model.

Frost plot of the prevalence of S. stercoralis across regions using random effect model.

Frost plot of S. stercoralis prevalence across different diagnostic methods using random effect model.

j_helm-2021-0010_tab_001

No	First Authors	Year of Pub	Region	Participant history	Sample size	No SS cases	Prevalence (95%CI)	Diagnostic method
1	Hailu T	2020	Amhara	Sch	844	127	15.05 [12.74-17.68]	FECT,STST,BCT,APC
2	Aramendia AA	2020	Amhara	>5 years	792	441	55.68 [52.14-59.17]	FECT,BCT,PCR
3	Getaneh F	2020	Amhara	Patient	67	2	3.0 [0.82-10.25	DSM, KK
4	Kuti KA	2020	Oromia	FH	198	8	4.04 [2.06-7.77]	DSM, FECT
5	Tsegay B	2020	SNNPR	Children	622	12	1.93 [1.11-3.34]	DSM,FECT
6	Menjetta T	2019	SNNPR	UN/student	13,679	41	0.30 [0.22-0.41]	DSM
7	Gemech A	2019	SNNPR	Prisoner	320	18	5.63 [3.59-8.72]	DSM, FECT
8	Alemu G	2019	SNNPR	Sch	351	7	1.99 [0.97-0.41]	DSM, FECT
9	Alemu G	2018	SNNPR	HIV	220	4	1.82 [0.71-4.58]	DSM, FECT
10	Gebretsadik D	2018	Amhara	HIV	223	1	0.45 [0.02-2.86]	DSM, FECT
11	Hailegebriel T	2018	Amhara	Sch	382	5	1.31 [0.48-3.21	FECT
12	Teklmariam D	2018	Oromia	Sch	280	4	1.43 [0.46-3.87]	FECT,KK
13	Mengist HM	2017	Oromia	Pregnant	372	1	0.27 [0.01-1.73]	DSM,FECT
14	Eshetu T	2017	Amhara	HIV	223	8	3.59 [1.68-7.21]	FECT
15	Feleke DG	2017	Tigray	Patient	7,663	47	0.61 [0.45-0.82]	DSM,FECT
16	Alemu M	2017	Tigray	Patient	427	8	1.87 [0.87-3.80]	DSM,KK
17	Hailegebriel T	2017	AA	Patient	351	43	12.25 [9.22-16.09]	DSM,FECT, BCT Culture
18	Abdi M	2017	Amhara	Sch	408	3	0.74 [0.25-2.15]	FECT
19	Derso A	2016	Amhara	Pregnant	348	6	1.72 [0.79-3.70]	FECT
20	Amor A	2016	Amhara	Sch	396	82	20.71 [17.01-24.97]	FECT,BCT, PCR
21	Shimlis T	2016	SNNPR	HIV	491	22	4.48 [2.90-6.81]	DSM,FECT
22	Shiferaw MB	2015	Amhara	Patient	464	5	1.08 [0.40-2.65]	DSM,FECT
23	Aleka Y	2015	Amhara	Patient	277	1	0.36 [0.06-2.01]	DSM,FECT
24	Gedle D	2015	SNNPR	HIV	305	5	1.6 4[0.70-3.78]	DSM, FECT
25	Ramos JM	2014	SNNPR	Patient	32,191	92	0.29 [0.24-0.35]	DSM
26	Mekonnen B	2014	AA	St/dweller	355	19	5.35 [3.45-8.20]	DSM, FECT, KK
27	Mamo H	2014	Amhara	Prisoner	236	6	2.54 [1.10-5.71]	DSM,FECT
28	Eriso F	2014	SNNPR	Sch	710	142	20.0 [17.16-23.17]	BCT
29	Mahmud MA	2013	Tigray	Sch	600	5	0.83 [0.31-2.05]	DSM,FECT,KK
30	Adamu H	2013	Oromia	HIV	378	1	0.26 [0.01-1.69]	DSM,FECT
31	Bayessa C	2013	SNNPR	Patient	6,342	73	1.15 [0.92-1.44]	DSM, FECT
32	Abera B	2013	Amhara	Sch	778	27	3.47 [2.40-5.00]	FECT, KK
33	Zeynudin A	2013	Oromia	HIV	91	6	6.59 [3.05-13.64]	DSM,FECT
34	Abate A	2013	Amhara	Patient	410	1	0.24 [0.04-1.36]	DSM, FECT
35	King JD	2013	Amhara	Children	2,338	5	0.21 [0.09-0.49]	FECT
36	Fekadu S	2013	SNNPR	HIV	343	12	3.50 [2.01-6.02]	DSM, FECT
37	Teklemariam Z	2013	Harari	HIV	371	15	4.04 [2.46-6.56]	DSM,FECT
38	Wogayehu T	2013	SNNPR	All age	858	51	5.94 [4.55-7.73]	DSM,FECT
39	Huruy K	2011	Amhara	Patient	384	12	3.13 [1.80-5.39]	DSM
40	Legese L	2010	Tigray	Sch	386	1	0.26 [0.05-1.45]	KK
41	Nyantekyi LA	2010	SNNPR	Children	288	2	0.69 [0.19-2.49]	FECT, KK
42	Getaneh A	2010	SNNPR	HIV	384	27	7.03 [4.88-10.04]	DSM, FECT, BCT
43	Belyhun Y	2010	SNNPR	Kid+ Mother	1,813	39	2.15 [1.58-2.93]	FECT

	Total				78,959	1,437	1.82 [1.73-1.92]

The prevalence of S_ stercoralis using different diagnostic methods in Ethiopia between 2010 – 2020_

Diagnostic methods	No of studies [N]	Total examined [N]	S. stercoralis Positive [N]	Pooled prevalence (95%CI)
DSM	3	46,254	145	0.31 [0.26 – 0.36]
KK	1	386	1	0.26 [0.05 – 1.45]
FECT	6	5,512	66	1.20 [0.94 – 1.53]
BCT	1	710	142	20.0 [17.16 – 23.17]1
DSM+KK	2	494	10	2.02 [1.10 – 3.68]
DSM+FECT	20	20,535	296	1.44 [1.28 – 1.61]
FECT+KK	3	1,346	33	2.45 [1.72 – 3.46]
DSM+FECT+KK	2	955	24	2.51 [1.65 – 3.77]
DSM+FECT+BCT	1	384	27	7.03 [4.88 – 10.04]
FECT+BCT+PCR	2	1,188	523	44.02 [41.18 – 46.90]
DSM+FECT+BCT+CULTURE	1	351	43	12.25 [9.22 – 16.09]
FECT+STST+BCT+CULTURE	1	844	127	15.05 [12.74 – 17.68]

TOTAL	43	78,959	1,437

The prevalence of S_ stercoralis in different regions of Ethiopia between 2010 – 2020_

Name of the region	Number of studies [N]	Total examined [N]	SS Positive [N]	Pooled prevalence (95%CI)
Addis Ababa City	2	706	62	8.78 [6.85 – 11.17]
Amhara	16	8,570	732	8.54 [7.96 – 9.16]
Harari	1	371	15	4.04 [2.36 – 6.72]
Oromia	5	1319	20	1.52 [0.96 – 2.38]
SNNPR	15	58,917	547	0.93 [0.85 – 1.01]
Tigray	4	9,076	61	0.67 [0.52 – 0.86]

Total	43	78,959	1,437	1.82 [1.73 – 1.92]

Strongyloides stercoralis infection in Ethiopia: systematic review and meta-analysis on prevalence and diagnostic methods

Figures & Tables

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Fig 5

j_helm-2021-0010_tab_001

The prevalence of S_ stercoralis using different diagnostic methods in Ethiopia between 2010 – 2020_

The prevalence of S_ stercoralis in different regions of Ethiopia between 2010 – 2020_

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