Abstract
Quality Assurance (QA) is an essential component for the success and effectiveness of European projects, which are characterized by intrinsic complexity, multinational collaborations, and the management of structural funds. This article explores the role of QA, outlining its theoretical framework, analyzing specific challenges, and presenting best practices adopted to mitigate them. Through the examination of case studies, the adaptability and relevance of QA in various sectors funded by the European Union are highlighted, integrating a critical reflection on the current debate regarding the upcoming Framework Programme 10 (Horizon Europe 2028–2034) and the positions of the European University Association. The article concludes with a discussion of future prospects and emerging areas of research, emphasizing how QA can act not only as a management tool but also as a systemic guarantee of autonomy, transparency, and scientific excellence.