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Association between calcium supplementation and bone mineral density in children: a systematic review and meta-analysis Cover

Association between calcium supplementation and bone mineral density in children: a systematic review and meta-analysis

Open Access
|Aug 2021

Figures & Tables

Figure 1

Literature screening process.
Literature screening process.

Figure 2

Risk bias evaluation diagram.
Risk bias evaluation diagram.

Figure 3

Meta-analysis of the effects of calcium supplements and placebo on the whole-body bone mineral density in healthy children.
Meta-analysis of the effects of calcium supplements and placebo on the whole-body bone mineral density in healthy children.

Figure 4

Meta-analysis of the effects of calcium supplements and placebo on the 2nd–4th lumbar vertebrae bone mineral density in healthy children.
Meta-analysis of the effects of calcium supplements and placebo on the 2nd–4th lumbar vertebrae bone mineral density in healthy children.

Figure 5

Meta-analysis of the effects of calcium supplement and placebo on the whole-body BMD in healthy children after exclusion of articles one by one.
Meta-analysis of the effects of calcium supplement and placebo on the whole-body BMD in healthy children after exclusion of articles one by one.

Figure 6

Meta-analysis of the effects of calcium supplements and placebo by fixed-effects model on the whole-body BMD in healthy children.
Meta-analysis of the effects of calcium supplements and placebo by fixed-effects model on the whole-body BMD in healthy children.

Figure 7

Meta-analysis of the effects of calcium supplement and placebo on the 2nd–4th lumbar vertebrae BMD in healthy children after exclusion of articles one by one.
Meta-analysis of the effects of calcium supplement and placebo on the 2nd–4th lumbar vertebrae BMD in healthy children after exclusion of articles one by one.

Figure 8

Meta-analysis of the effects of calcium supplements and placebo by random-effects model on the 2nd–4th lumbar vertebrae BMD in healthy children.
Meta-analysis of the effects of calcium supplements and placebo by random-effects model on the 2nd–4th lumbar vertebrae BMD in healthy children.

Basic characteristics of included RCTs_

Inclusive RCTsPopulationSample sizeAges (years)Intervention measuresIntervention duration (years)Dose (mg)Percentage of lost visits (%)Outcome indicators


Control groupIntervention groupIC
Cheng 200512Healthy children413910–12CalciumPlacebo2100018.7Whole-body BMD
Anuradha 201214Healthy children70698–12CalciumMultivitamin tablets15001.8Whole-body BMD
Lambert 200810Healthy children373611–12Calcium fortified fruit drinksRegular fruit drinks17927.2Whole-body and 2nd–4th lumbar vertebrae BMD
Bonjour 200113Healthy children62547–9.3CalciumPlacebo3–585024.12nd–4th lumbar vertebrae BMD
DOI: https://doi.org/10.2478/fon-2021-0019 | Journal eISSN: 2544-8994 | Journal ISSN: 2097-5368
Language: English
Page range: 169 - 176
Submitted on: Jul 14, 2020
|
Accepted on: Aug 17, 2020
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Published on: Aug 18, 2021
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Jin-Ping Gao, Hong-Xia Ren, Yan-Fei Wang, Shi-Fan Han, Chang-Tai Zhu, published by Shanxi Medical Periodical Press
This work is licensed under the Creative Commons Attribution 4.0 License.