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α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom Cover

α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom

Folia Horticulturae
Volume 35 (2023): Issue 2 (December 2023)
By: Ayman Turk,  Solip Lee,  Hak Hyun Lee,  Sang Won Yeon,  Se Hwan Ryu,  Geum Hee Seo,  Hyun You Chang,  Bang Yeon Hwang and  Mi Kyeong Lee  
Open Access
|Dec 2023

Figures & Tables

Figure 1.

Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.
Characterisation of Morchella fluvialis. Phylogenetic analysis was conducted based on ITS1 and ITS4 sequence data. The length of the branches corresponds to the cumulative number of nucleotide substitutions in the DNA sequences under analysis. The sequences were obtained from GeneBank and EMBL databases, and their corresponding accession numbers are given within brackets.

Figure 2.

Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.
Effects of total extract and different fractions of M. fluvialis on α-glucosidase inhibitory and antioxidant activities. All data are presented as mean ± SEM (n = 3). *p < 0.05 and **p < 0.01, ***p < 0.001 indicates significant differences compared to the control group.

Figure 3.

Chemical structures of compounds 1–9 isolated from M. fluvialis.
Chemical structures of compounds 1–9 isolated from M. fluvialis.

Figure 4.

[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.
[A] HPLC chromatogram and [B] amount of compound 1 of total extract and different fractions of M. fluvialis.

Supplementary Scheme S1.

Extraction and isolation of sterols.
Extraction and isolation of sterols.

Supplementary Figure S1.

1H NMR spectrum of compound 1 (CDCl3, 500 MHz).
1H NMR spectrum of compound 1 (CDCl3, 500 MHz).

Supplementary Figure S2.

13C NMR spectrum of compound 1 (CDCl3, 125 MHz).
13C NMR spectrum of compound 1 (CDCl3, 125 MHz).

Supplementary Figure S3.

1H NMR spectrum of compound 2 (CDCl3, 500 MHz).
1H NMR spectrum of compound 2 (CDCl3, 500 MHz).

Supplementary Figure S4.

13C NMR spectrum of compound 2 (CDCl3, 125 MHz).
13C NMR spectrum of compound 2 (CDCl3, 125 MHz).

Supplementary Figure S5.

1H NMR spectrum of compound 3 (CDCl3, 500 MHz).
1H NMR spectrum of compound 3 (CDCl3, 500 MHz).

Supplementary Figure S6.

13C NMR spectrum of compound 3 (CDCl3, 125 MHz).
13C NMR spectrum of compound 3 (CDCl3, 125 MHz).

α-Glucosidase inhibitory activity of compounds 1–6 from M_ fluvialis_

Compoundα-Glucosidase inhibitory activity (100 μM)IC50 (μM)
189.2 ± 3.414.8
253.1 ± 6.395.2
332.8 ± 6.6>100
424.8 ± 6.5>100
521.9 ± 0.3>100
617.0 ± 0.3>100
Acarbose*76.4 ± 3.472.5
DOI: https://doi.org/10.2478/fhort-2023-0026 | Journal eISSN: 2083-5965 | Journal ISSN: 0867-1761
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Language: English
Page range: 369 - 379
Submitted on: Feb 17, 2023
|
Accepted on: Aug 4, 2023
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Published on: Dec 31, 2023
Published by: Polish Society for Horticultural Sciences (PSHS)
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
α-glucosidase,
linoleic acid,
morel
Related subjects:
Life sciences,
Plant science,
Zoology,
Ecology,
Life sciences, other

© 2023 Ayman Turk, Solip Lee, Hak Hyun Lee, Sang Won Yeon, Se Hwan Ryu, Geum Hee Seo, Hyun You Chang, Bang Yeon Hwang, Mi Kyeong Lee, published by Polish Society for Horticultural Sciences (PSHS)
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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