Prognostic Impact of ALK on Anaplastic Large Cell Lymphoma of CNS

Raj Roy; Debojit Das; Anubhav Bhaumik; Chitrita Kundu

doi:10.2478/fco-2024-0020

Figures & Tables

Flow chart of the study selection process.

Kaplan–Meier curve for overall survival (in months) following anaplastic large cell lymphoma of the central nervous system

Kaplan–Meier analysis to assess overall survival (in months) based on ALK status (86%: 2-yr survival in ALK+) (p=0.002).

Kaplan–Meier analysis to assess overall survival (in months) based on age (76%: 2-yr survival in patients aged less than 18 yr and 63%: 2-yr survival in patients aged more than 18 yr) (p=0.638).

Kaplan–Meier analysis to assess overall survival (in months) based on involvement of meninges (83%: 2-yr survival in patients in whom meninges are involved and 34%: in patients without any meningeal involvement) (p=0.002).

Kaplan–Meier analysis to assess overall survival (in months) based on immune cell marker (84%: 2-yr survival in cases with T cell as biomarker) (p=0.041)

List of reported cases of ALCL of central nervous system included in this study; ALCL- anaplastic large cell lymphoma; sex (M- male, F- female); lesion (M- multifocal, S- single); ALK- anaplastic lymphoma kinase, LCA- leucocyte common antigen; EMA- epithelial membrane antigen; NED- no evidence of disease

Case no	Authors	Age	Sex	Location	Lesion	Meningeal involvement	Marker	ALK status	Immunohistochemistry	Chemotherapy	Radiation	Methotrexate	Survival
1	Dong et al	34	M	Spinal cord	M	P	null	+	CD30, Vimentin, LCA, TIA1, CD56	y	y	y	NED at 12 month
2	Wang et al	59	M	Frontal lobe	S	A	T cell	+	CD30, CD43, EMA	y	n	n	NED at 6 month
3	Kim et al	30	M	Pariental and occipital dura	S	P	T cell	+	CD30, EMA	y	y	y	NED at 16 month
4	Kodama et al	79	M	Parieto-occipital region	S	A	null	-	CD3, CD30, CD45RO	n	n	n	Died at 4 month
5	Sugino et al	75	M	Bilateral hemisphere	M	A	T cell	-	CD30, CD45	y	y	n	died at 8 month
6	Zhang et al	27	M	Parieto-occipital region	S	P	T cell	+	CD30	y	y	y	NED at 88 month
7	Zhang et al	65	M	Basal ganglia	S	A	T cell	-	CD3	y	n	y	dead at 26 month
8	Mark et al	38	M	Parieto-occipital region	S	A	T cell	+	CD30, CD45	y	y	y	NED at 15 month
9	Vivekanandan et al	20	M	Sylvian fissure	S	P	T cell	+	CD3, CD30	y	y	y	NED at 96 months
10	Karikari et al	4	M	Frontal and parietal lobe, pineal	M	P	T cell	+	CD30, CD7	y	y	n	NED at 1 month
11	Ponzoni et al	29	M	Frontotemporal	M	P	T cell	+	CD30, CD3, CD45RO	y	y	y	NED at 19 month
12	George et al	17	M	Parietal dura	S	P	T cell	+	CD3, CD43, CD45RO	n	y	n	NED at 58 month
13	George et al	18	F	Temporal lobe	M	P	T cell	+	CD45RO	y	y	n	NED at 62 months
14	George et al	22	F	Cerebellum	M	A	T cell	-	CD3, CD8	n	n	n	Dead at 11 days
15	Merlin et al	13	M	Frontal dura	S	P	T cell	+	CD30, Ki67	y	y	y	Dead at 27 months
16	Ozkaynak et al	9	M	Bilateral frontal	M	P	T cell	+	LCA, CD3, CD8	y	y	y	NED at 26 months
17	Shah et al	2	M	Dura mater	S	P	T cell	+	CD30, CD43	y	n	y	NED at 108 month
18	Park et al	31	M	Leptomeningeal	S	P	T cell	+	CD30, CD5, EMA, CD45RO	y	n	y	NED at 18 month
19	Dunbar et al	10	M	Fontal lobe, basal ganglia	S	P	T cell	+	CD3, LCA, CD30	y	y	y	NED at 36 month
20	kuntegowdenahalli et al	18	M	Parietal and occipital lobe	S	P	T cell	+	LCA, CD30, CD4	y	y	y	NED at 1 month
21	Kaku et al	21	M	Frontoparietal dura	S	P	T cell	+	LCA, CD45, CD30, Ki67	y	y	y	NED at 24 month
22	Feng et al	8	M	Occipital lobe	S	A	null	+	CD3, CD30, EMA	n	n	n	Dead at 2 month
23	Liu et al	12	M	Occipital lobe, falx	M	P	null	+	CD30, CD3, CD5, CD56	n	n	n	Dead at 1 month
24	El farissi et al	16	F	Spinal cord	M	A	T cell	+	CD30, CD5, Ki67	y	n	n	NED at 1 month
25	Verran et al	20	M	Parieto leptomeningeal	S	P	null	+	CD30, CD7	y	n	y	NED at 24 months
26	Brady et al	68	M	Occipital lobe	S	A	T cell	-	CD30, CD2, INI1, P53, Ki67	y	n	y	NED at 8 month
27	Lee et al	12	M	Parietal dura	M	P	null	+	CD30	y	n	y	NED at 16 month
28	Omae et al	26	F	Neurohypophysis and pineal gland	M	A	null	+	CD3, CD30	y	n	y	NED at 24 months
29	Strosberg et al	29	F	Frontal lobe, basal ganglia	M	A	null	+	CD30, CD5, CD20	y	n	y	Died at 39 month
30	Lannon et al	63	M	Intracranial	M	P	T cell	-	CD30, MUM1, CD99, CD2	y	n	y	NED at 18 month

Prognostic Impact of ALK on Anaplastic Large Cell Lymphoma of CNS

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