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A rare case of medullary carcinoma of colon: Clinical implications and role of adjuvant therapy Cover

A rare case of medullary carcinoma of colon: Clinical implications and role of adjuvant therapy

Forum of Clinical Oncology
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By: Lakshmi Manogna Chintalacheruvu,  Vamsi Krishna Chilluru,  Narendra Babu Gutta and  Heather Barrett  
Open Access
|Jul 2025

Figures & Tables

Figure 1:

Circumferential thickening and heterogenous attenuation of the ascending colon just proximal to the level of the hepatic flexure.
Circumferential thickening and heterogenous attenuation of the ascending colon just proximal to the level of the hepatic flexure.

Figure 2:

Higher magnification reveals poorly differentiated cells with medium to large-sized vesicular nuclei, nucleoli, and moderate eosinophilic cytoplasm. The larger carcinomatous cells are interspersed by the smaller tumor infiltrating lymphocytes.
Higher magnification reveals poorly differentiated cells with medium to large-sized vesicular nuclei, nucleoli, and moderate eosinophilic cytoplasm. The larger carcinomatous cells are interspersed by the smaller tumor infiltrating lymphocytes.

Figure 3:

The medullary carcinoma is composed of poorly to undifferentiated cells in a vaguely trabecular to solid pattern. It lacks the typical glandular formation and mucin content seen in traditional colonic adenocarcinomas. The carcinoma has a circumscribed, pushing border, with a brisk intraepithelial and peritumoral lymphocytic infiltration.
The medullary carcinoma is composed of poorly to undifferentiated cells in a vaguely trabecular to solid pattern. It lacks the typical glandular formation and mucin content seen in traditional colonic adenocarcinomas. The carcinoma has a circumscribed, pushing border, with a brisk intraepithelial and peritumoral lymphocytic infiltration.
DOI: https://doi.org/10.2478/fco-2024-0005 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Submitted on: Nov 29, 2024
Accepted on: Jan 26, 2025
Published on: Jul 11, 2025
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
medullary carcinoma,
colon,
adjuvant therapy,
stage 2,3,
chemotherapy
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2025 Lakshmi Manogna Chintalacheruvu, Vamsi Krishna Chilluru, Narendra Babu Gutta, Heather Barrett, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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