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A rare case of medullary carcinoma of colon: Clinical implications and role of adjuvant therapy Cover

A rare case of medullary carcinoma of colon: Clinical implications and role of adjuvant therapy

Forum of Clinical Oncology
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By: Lakshmi Manogna Chintalacheruvu,  Vamsi Krishna Chilluru,  Narendra Babu Gutta and  Heather Barrett  
Open Access
|Jul 2025

Figures & Tables

Figure 1:

Circumferential thickening and heterogenous attenuation of the ascending colon just proximal to the level of the hepatic flexure.

Figure 2:

Higher magnification reveals poorly differentiated cells with medium to large-sized vesicular nuclei, nucleoli, and moderate eosinophilic cytoplasm. The larger carcinomatous cells are interspersed by the smaller tumor infiltrating lymphocytes.

Figure 3:

The medullary carcinoma is composed of poorly to undifferentiated cells in a vaguely trabecular to solid pattern. It lacks the typical glandular formation and mucin content seen in traditional colonic adenocarcinomas. The carcinoma has a circumscribed, pushing border, with a brisk intraepithelial and peritumoral lymphocytic infiltration.
DOI: https://doi.org/10.2478/fco-2024-0005 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Submitted on: Nov 29, 2024
|
Accepted on: Jan 26, 2025
|
Published on: Jul 11, 2025
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
medullary carcinoma,
colon,
adjuvant therapy,
stage 2,3,
chemotherapy
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2025 Lakshmi Manogna Chintalacheruvu, Vamsi Krishna Chilluru, Narendra Babu Gutta, Heather Barrett, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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