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Supplementary FCO 2024 Cover

Figures & Tables

Figure 1.

PET-CT showing a hypermetabolic submandibular lymph node block (primary tumor - left) and a suspicious, hypermetabolic. area on the right sternocleidomastoid (recurrence of squamous cell carcinoma - right).
PET-CT showing a hypermetabolic submandibular lymph node block (primary tumor - left) and a suspicious, hypermetabolic. area on the right sternocleidomastoid (recurrence of squamous cell carcinoma - right).

Figure 2.

Histopathological examination of the postauricular lesion, revealing scattered p16+ cells, indicative of recurrent squamous cell carcinoma, HPV related.
Histopathological examination of the postauricular lesion, revealing scattered p16+ cells, indicative of recurrent squamous cell carcinoma, HPV related.

Figure 1.

Brain MRI scan demonstrating a space-occupying lesion in the right nasal cavity with heterogenous contrast enhancement.
Brain MRI scan demonstrating a space-occupying lesion in the right nasal cavity with heterogenous contrast enhancement.

Figure 2.

Brain MRI scan (sagittal) demonstrating a large lymph node block in the right submandibular region.
Brain MRI scan (sagittal) demonstrating a large lymph node block in the right submandibular region.

Figure 3.

Spinal MRI scan (coronal) showing multiple bone-lytic lesions indicative of metastases along the spine.
Spinal MRI scan (coronal) showing multiple bone-lytic lesions indicative of metastases along the spine.

Figure 4.

Histopathological examination reveals characteristics of a small round blue cells tumor (hematoxylin–eosin stain, x20 magnification).
Histopathological examination reveals characteristics of a small round blue cells tumor (hematoxylin–eosin stain, x20 magnification).

Figure 5.

Tumor cells display a high ki67 proliferation index (ki67 85%, x10 magnification).
Tumor cells display a high ki67 proliferation index (ki67 85%, x10 magnification).

j_fco-2024-0001_tab_002

Characteristic LCNEC

Age59 (27 – 86)66.5 (39–84)

Male (%)3979
Type of Biopsy (%)
• Bronchoscopic14.621
• CT-guided010.5
• Surgical85.368.4
Smoking Status (%)
• Never34.22.6
• Current34.276.3
• Former31.721
Symptoms Leading to Diagnosis (%)
• Asymptomatic63.436.8
• Hemoptysis12.210.5
• Cough12.231.5
• Dyspnea9.831.5
• Recurrent respiratory infections2.47.9
Location (%)
• Left upper lobe9.721.0
• Left lower lobe21.913.1
• Right upper lobe21.936.8
• Right middle lobe24.32.6
• Right lower lobe12.215.8
• Lingula2.42.6
Stage (8th TNM Edition) (%)
• IA41.47.9
• IB7.35.2
• IIA12.27.9
• IIB9.77.9
• IIIA14.67.9
• IIIB4.85.2
• IIIC05.2
• IVA4.823.6
• IVB4.828.9
• Ki67%7 (1–30)70 (40–90)

j_fco-2024-0001_tab_001

TABLEInterD (N=701) (N/%)ProD (N=430) (N/%)pOR (95%CI)
Males416/63.7214/55.40.0081.4 (1.1–1.8)
Metastasis535/79.0259/67.3<.00011.8 (1.4–2.4)
HTAs597/85.4338/79.20.0071.5 (1.1–2.1)
ESA133/19.061/14.20.0381.4 (1.0–2.0)
Radiotherapy126/18.18106/24.90.0070.7 (0.5–0.9)
History of Bleeding2/0.36/1.40.0310.2 (0.0–1.0)
Heart or vascular disease139/2880/35.40.0440.7 (0.5–0.9)
Immobility43/6.146/10.70.0060.6 (0.4–0.8)
Lung disease20/4.017/7.50.0480.5 (0.3–0.9)
Metabolic disease96/19.360/26.60.0280.7 (0.5–0.9)
Surgery269/38.4250/58.3<.00010.5 (0.4–0.6)
Bleedings11/1.611/2.60.2420.6 (0.3–1.4)
Thrombotic events11/1.620/4.70.0020.3 (0.2–0.7)
DOI: https://doi.org/10.2478/fco-2024-0001 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
Language: English
Page range: 1 - 62
Published on: Apr 3, 2025
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2025 , published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 15 (2024): Issue 2 (December 2024)