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Antidiabetic agents as potential cytotoxic candidates for cancer therapy Cover

Antidiabetic agents as potential cytotoxic candidates for cancer therapy

Forum of Clinical Oncology
Volume 15 (2024): Issue 1 (December 2024)
By: Raniah I. Alnaser,  Fawaz A. Alassaf and  Mohammed N. Abed  
Open Access
|Jun 2025

Figures & Tables

Figure 1:

Difference in glucose metabolism between normal and cancer cells [22].
Difference in glucose metabolism between normal and cancer cells [22].

Figure 2:

Internal metabolism of cancer cells.
Internal metabolism of cancer cells.

Summary of the cytotoxic effects of some antidiabetic drugs_

Antidiabetics classDrug nameTumor typesReferences
BiguanideMetforminBreast cancer[45]
Colorectal cancer[46]
Endometrial cancer[47]
Ovarian cancer[183]
Skin cancer[184,185]
Thyroid cancer[186]
Head and neck cancer[175]
Pancreatic cancer[187]
Lung cancer[54]
SulfonylureaGlibenclamideGastric cancer[76]
Breast cancer[69]
Hepatocellular carcinoma[70,73]
Colon cancer[75]
Glioblastoma[72]
ThiazolidinedioneRosiglitazoneNeuroblastoma[83]
GliptinsVildagliptin and sitagliptinColorectal cancer[96,102] [97]
Vildagliptin, sitagliptin, and gemigliptinThyroid cancer[93,104,105]
Vildagliptin, sitagliptin, and sitagliptinChronic myeloid leukemia[106,107]
VildagliptinLung cancer[103]
SitagliptinGastric cancer[94]
Breast cancer[98]
Endometrial cancer[95]
Cervical carcinoma[99]
Glioblastoma cancer in the brain[100,101]
GLP-1 agonistsExenatide-4Hepatocellular carcinoma[112,113]
Breast cancer[114]
Prostate cancer[115]
Endometrial cancer[116]
LiraglutideEndometrial cancer[116]
SGLT2 inhibitorsDapagliflozinPancreatic carcinoma[38,123]
Renal carcinoma (in humans)[129]
Human colon carcinoma[188]
CanagliflozinPancreatic cancer and early-stage lung cancer[38,125,189] [130]
Hepatocellular carcinoma (in humans)[190]
Lung cancer[191]
Breast cancer[191,192]
Prostate cancer[192]
Thyroid cancer[131]
IpragliflozinBreast carcinoma[128]
DOI: https://doi.org/10.2478/fco-2023-0041 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 68 - 89
Submitted on: Mar 16, 2024
|
Accepted on: Aug 16, 2024
|
Published on: Jun 10, 2025
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Cancer,
Diabetes Mellitus,
Glucose Deprivation,
Antidiabetics,
Cytotoxicity
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2025 Raniah I. Alnaser, Fawaz A. Alassaf, Mohammed N. Abed, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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