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LDL/HDL ratio and HOMA-IR as markers of severity of peripheral neuropathy in diabetic population Cover

LDL/HDL ratio and HOMA-IR as markers of severity of peripheral neuropathy in diabetic population

Open Access
|Dec 2025

References

  1. Abosrea M, Elmasry HA, Oraby MI. Gender differences in diabetic peripheral neuropathy. Egyptian J Med Res 1, 55–64, 2020.
  2. Afshinnia F, Reynolds EL, Rajendiran TM, Soni T, Byun J, Savelieff MG, Looker HC, Nelson RG, Michailidis G, Callaghan BC, Pennathur S, Feldman EL. Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes. Ann Clin Transl Neurol 9, 1392–1404, 2022.
  3. AlShareef AA, Alrawaili MS, Almutairi SA, Ayyad MM, Alshora W. Association of hematological parameters and diabetic neuropathy: a retrospective study. Diabetes Metab Syndr Obes 17, 779–793, 2024.
  4. Amour AA, Chamba N, Kayandabila J, Lyaruu IA, Marieke D, Shao ER, Howlett W. Prevalence, patterns, and factors associated with peripheral neuropathies among diabetic patients at tertiary hospital in the Kilimanjaro region: descriptive cross-sectional study from North-Eastern Tanzania. Int J Endocrinol 2019, 5404781, 2019.
  5. Atmaca A, Ketenci A, Sahin I, Sengun IS, Oner RI, Tilki HE, Adas M, Soyleli H, Demir T. Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach. Front Endocrinol 15, 1380929, 2024.
  6. Barbosa M, Saavedra A, Oliveira S, Reis L, Rodrigues F, Severo M, Sittl R, Maier C, Carvalho DM. Prevalence and determinants of painful and painless neuropathy in type 1 diabetes mellitus. Front Endocrinol 10, 402, 2019.
  7. Cai Z, Yang Y, Zhang J. A systematic review and meta-analysis of the serum lipid profile in prediction of diabetic neuropathy. Sci Rep 11, 499, 2021.
  8. Chang KC, Pai YW, Lin CH, Lee IT, Chang MH. Glycemic variability’s impact on painful diabetic peripheral neuropathy in type 2 diabetes patients. Sci Rep 14, 22276, 2024.
  9. Cho YN, Lee KO, Jeong J, Park HJ, Kim SM, Shin HY, Hong JM, Ahn CW, Choi YC. The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study. Yonsei Med J 55, 700–708, 2014.
  10. Dhillon S, Fithrie A, Batubara CA. The association between waist hip ratio and severity of diabetic peripheral neuropathy in diabetes mellitus type 2 by using Toronto Clinical Scoring System. J Social Med 2, 107–116, 2023.
  11. Dinh Le T, Phi Thi Nguyen N, Thanh Thi Tran H, Luong Cong T, Ho Thi Nguyen L, Do Nhu B, Tien Nguyen S, Van Ngo M, Trung Dinh H, Thi Nguyen H, Trung Nguyen K, Le DC. Diabetic peripheral neuropathy associated with cardiovascular risk factors and glucagon-like peptide-1 concentrations among newly diagnosed patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes 15, 35–44, 2022.
  12. Eid SA, Rumora AE, Beirowski B, Bennett DL, Hur J, Savelieff MG, Feldman EL. New perspectives in diabetic neuropathy. Neuron 111, 2623–2641, 2023.
  13. Firouzabadi MD, Poopak A, Sheikhy A, Samimi S, Nakhaei P, Firouzabadi FD, Moosaie F, Rabizadeh S, Nakhjavani M, Esteghamati A. Glycemic profile variability: An independent risk factor for diabetic neuropathy in patients with type 2 diabetes. Prim Care Diabetes 17, 38–42, 2023.
  14. Gonzalez-Gonzalez JG, Violante-Cumpa JR, Zambrano-Lucio M, Burciaga-Jimenez E, Castillo-Morales PL, Garcia-Campa M, Solis RC, Gonzalez-Colmenero AD, Rodriguez-Gutierrez R. HOMA-IR as a predictor of health outcomes in patients with metabolic risk factors: a systematic review and meta-analysis. High Blood Press Cardiovasc Prev 29, 547–564, 2022.
  15. Han L, Ji L, Chang J, Wen J, Zhao W, Shi H, Zhou L, Li Y, Hu R, Hu J, Lu B. Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome. Diabetol Metab Syndr 7, 14, 2015.
  16. Huma K, Mehboob K, Rashid A, Fuad F, Mujahid MM, Arshad A. Comparison of lipid profile in patients with diabetic neuropathy and without neuropathy; a cross sectional study. Pakistan Armed Forces Med J 71, 2021.
  17. IDF Diabetes Atlas 11th Edition 2025. Online version available at diabetesatlas.org.
  18. Javed A, Furqan A, Zaheer M, Kasuri N. Gender based differences in diabetic peripheral neuropathy. Pakistan J Neurol Sci 9, 20–24, 2014.
  19. Jia Y, Long D, Yang Y, Wang Q, Wu Q, Zhang Q. Diabetic peripheral neuropathy and glycemic variability assessed by continuous glucose monitoring: A systematic review and meta-analysis. Diabetes Res Clin Pract 213, 111757, 2024.
  20. Kristensen FPB, Christensen DH, Callaghan BC, Nielsen JS, Hojlund K, Andersen H, Dekkers OM, Groenwold RHH, Sorensen HT, Thomsen RW. Lipid levels and risk of diabetic polyneuropathy in 2 Danish type 2 diabetes cohorts. Neurology 103, e209538, 2024.
  21. Liu J, Yuan X, Liu J, Yuan G, Sun Y, Zhang D, Qi X, Li H, Zhang J, Wen B, Guo X. Risk factors for diabetic peripheral neuropathy, peripheral artery disease, and foot deformity among the population with diabetes in Beijing, China: a multicenter, cross-sectional study. Front Endocrinol 13, 824215, 2022.
  22. Ma Q. Analysis of factors related to type 2 diabetic peripheral neuropathy based on flash glucose monitoring system. Med Sci Monit 29, e939157, 2023.
  23. Mayeda L, Katz R, Ahmad I, Bansal N, Batacchi Z, Hirsch IB, Robinson N, Trence DL, Zelnick L, de Boer IH. Glucose time in range and peripheral neuropathy in type 2 diabetes mellitus and chronic kidney disease. BMJ Open Diabetes Res Care 8, e000991, 2020.
  24. Mehta M, Shah J, Joshi U. Understanding insulin resistance in NAFLD: a systematic review and meta-analysis focused on HOMA-IR in South Asians. Cureus 16, e70768, 2024.
  25. Mokhtarpour K, Yadegar A, Mohammadi F, Aghayan SN, Seyedi SA, Rabizadeh S, Esteghamati A, Nakhjavani M. Impact of gender on chronic complications in participants with type 2 diabetes: evidence from a cross-sectional study. Endocrinol Diabetes Metab 7, e488, 2024.
  26. Nisar MU, Asad A, Waqas A, Ali N, Nisar A, Qayyum MA, Maryam H, Javaid M, Jamil M. Association of diabetic neuropathy with duration of type 2 diabetes and glycemic control. Cureus 7, e302, 2015.
  27. Nozawa K, Ikeda M, Kikuchi S. Association between HbA1c levels and diabetic peripheral neuropathy: a case-control study of patients with type 2 diabetes using claims data. Drugs Real World Outcomes 9, 403–414, 2022.
  28. Ponirakis G, Elhadd T, Al Ozairi E, Brema I, Chinnaiyan S, Taghadom E, Al Kandari J, Al Wotayan R, Al Ozairi A, Aljohani N, AlMistehi W, Al Qahtani N, Khan S, Dabbous Z, Siddique MA, Petropoulos IN, Khan A, Almuhannadi H, Ashawesh KA, Dukhan KM, Mahfoud ZR, Zirie MA, Jayyousi A, Malik RA. Prevalence and risk factors for diabetic peripheral neuropathy, neuropathic pain and foot ulceration in the Arabian Gulf region. J Diabetes Investig 13, 1551–1559, 2022.
  29. Sanchez-Pozos K, Monroy-Escutia J, Jaimes-Santoyo J, Granados-Silvestre MLA, Menjivar M, Ortiz-Lopez MG. Risk factors associated with diabetic neuropathy in Mexican patients. Cir Cir 89, 189–199, 2021.
  30. Singh A, Chauhan A, Goyal P, Kaur J, Ramesh P. Insulin resistance as a predictor of sensory neuropathy in prediabetes. Indian J Med Special 10, 95–98, 2019.
  31. Su JB, Zhao LH, Zhang XL, Cai HL, Huang HY, Xu F, Chen T, Wang XQ. HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients. Cardiovasc Diabetol 17, 47, 2018.
  32. Sun T, Chen M, Shen H, PingYin Fan L, Chen X, Wu J, Xu Z, Zhang J. Predictive value of LDL/HDL ratio in coronary atherosclerotic heart disease. BMC Cardiovasc Disord 22, 273, 2022.
  33. Uslu MF, Yilmaz M. Are inflammatory markers important for assessing the severity of diabetic polyneuropathy? Medicina 61, 400, 2025.
  34. Vincent AM, Hinder LM, Pop-Busui R, Feldman EL. Hyperlipidemia: a new therapeutic target for diabetic neuropathy. J Peripher Nerv Syst 14, 257–267, 2009.
  35. Vinik A, Ullal J, Parson HK, Casellini CM. Diabetic neuropathies: clinical manifestations and current treatment options. Nat Clin Pract Endocrinol Metab 2, 269–281, 2006.
  36. Wang CS, Pai YW, Lin CH, Lee IT, Chen HH, Chang MH. Diabetic peripheral neuropathy: age-stratified glycemic control. Front Endocrinol 15, 1377923, 2024.
  37. Yu Z, Zhao S, Cao J, Xie H. Analysis of risk factors for painful diabetic peripheral neuropathy and construction of a prediction model based on Lasso regression. Front Endocrinol 15, 1477570, 2024.
  38. Zhu J, Hu Z, Luo Y, Liu Y, Luo W, Du X, Luo Z, Hu J, Peng S. Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. Front Endocrinol 14, 1265372, 2024.
  39. Zhang H, Chen Y, Zhu W, Niu T, Song B, Wang H, Wang W, Zhang H. The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. Lipids Health Dis 22, 102, 2023.
DOI: https://doi.org/10.2478/enr-2025-0025 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668
Language: English
Page range: 217 - 226
Published on: Dec 12, 2025
Published by: Slovak Academy of Sciences, Institute of Experimental Endocrinology
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Anand Nisintha, Kumar Bhargavi, Thangavelu Saravanan, published by Slovak Academy of Sciences, Institute of Experimental Endocrinology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.