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Antioxidative role of propolis on LPS induced renal damage Cover

Antioxidative role of propolis on LPS induced renal damage

The EuroBiotech Journal
Volume 4 (2020): Issue 3 (July 2020)
By: Züleyha Doğanyiğit,  Birkan Yakan,  Aslı Okan and  Sibel Silici  
Open Access
|Jul 2020

Figures & Tables

Figure 1

Serum MDA levels of groups. The histogram bar graph data are expressed as mean ± SD, and compared by compared by one-way ANOVA and Tukey’s post hoc test for multiple comparisons test (α P<0.05 versus control group; β P<0.05 vs. LPS group; γ P<0.05 vs. Propolis group; ψ P<0.05 vs. LPS + Propolis group).
Serum MDA levels of groups. The histogram bar graph data are expressed as mean ± SD, and compared by compared by one-way ANOVA and Tukey’s post hoc test for multiple comparisons test (α P<0.05 versus control group; β P<0.05 vs. LPS group; γ P<0.05 vs. Propolis group; ψ P<0.05 vs. LPS + Propolis group).

Figure 2

A: Group 1 (control animals) revealed normal kidney structure (x40, PAS). B: Group 2 (LPS) kidney sections of rats demonstrated slight tubular damage (black arrow), ischemic damage in the form of vacuolization (thin black arrow), tubular dilatation (thick white arrow) and tubule epithelial vacuolization (*) (x40, PAS). C: Group 4 (Propolis+LPS) kidney sections of rats demonstrated ischemic damage (thick black arrow), tubule epithelial degeneration (*), (x40, PAS). D: Group 5 (LPS+Propolis) kidney sections demonstrated ischemic damage (thick black arrow), vascular congestion (thin white arrow) and reduced Bowman’s space (thin black arrow), (x40, PAS).
A: Group 1 (control animals) revealed normal kidney structure (x40, PAS). B: Group 2 (LPS) kidney sections of rats demonstrated slight tubular damage (black arrow), ischemic damage in the form of vacuolization (thin black arrow), tubular dilatation (thick white arrow) and tubule epithelial vacuolization (*) (x40, PAS). C: Group 4 (Propolis+LPS) kidney sections of rats demonstrated ischemic damage (thick black arrow), tubule epithelial degeneration (*), (x40, PAS). D: Group 5 (LPS+Propolis) kidney sections demonstrated ischemic damage (thick black arrow), vascular congestion (thin white arrow) and reduced Bowman’s space (thin black arrow), (x40, PAS).

Chemical content of propolis used in this study (GC-MS)

Compounds%Compounds%
Flavonoids41,2Aromatic acids and their esters27,13
4,5 dimethoxy-(2-propenyl) 2-phenolCaffeic acid
PinocembrinFerulic acid
ChrysinBenzoic acid
GalanginCaffeic acid phenetyhl ester
Organic and fatty acids12,63Alcohol, ketone and terpenes19,04
Decanoic acid2-propen-1-ol
4-pentenoic acid5-3,3-dimethyl-cyclohexanone
Cinnamic acid2-Nonadecanone
3-hydroxy-4-methoxycinnamic acidGamma-eudesmol
2-propenoic acidBeta-eudesmol
3,4-dimethoxycinnamic acidAlpha-eudesmol
Coumaric acidAlpha-bisabolol
9-Octadecanoic acid2-propen-1-one
Octadecanoic acid
DOI: https://doi.org/10.2478/ebtj-2020-0018 | Journal eISSN: 2564-615X
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Language: English
Page range: 156 - 160
Published on: Jul 19, 2020
Published by: European Biotechnology Thematic Network Association
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Sepsis,
Propolis,
LPS-induced,
MDA Levels,
Rat
Related subjects:
Life sciences,
Genetics,
Biotechnology,
Bioinformatics,
Life sciences, other

© 2020 Züleyha Doğanyiğit, Birkan Yakan, Aslı Okan, Sibel Silici, published by European Biotechnology Thematic Network Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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