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Chromatographic Retention of Naproxen-Based Thiourea Derivatives in a Micellar System as a Predictor of Passive Gastrointestinal Absorption Cover

Chromatographic Retention of Naproxen-Based Thiourea Derivatives in a Micellar System as a Predictor of Passive Gastrointestinal Absorption

Open Access
|Oct 2026

References

  1. Angiolillo DJ, Weisman SM. Clinical pharmacology and therapeutic use of naproxen. Am J Cardiovasc Drugs. 2017;17(2):97–107.
  2. Stoev SN, Gueorguiev SR, Madzharov VG, Lebanova HV. Naproxen in pain and inflammation - a review. Int J Pharm Phytopharmacol Res. 2021;11(1):142–8.
  3. Curini M, Epifano F, Fiorito S, Piacente S. Thiourea derivatives: synthesis, biological properties and therapeutic potential. Mini Rev Med Chem. 2012;12(8):776–95.
  4. Kumar S, Singh I, Kamboj S, Thakur AS. Thiourea-based anticancer agents: synthesis and biological evaluation. Eur J Med Chem. 2018;157:1137–51.
  5. Nedeljković N, Dobričić V, Bošković J, Vesović M, Bradić J, Anđić M et al. Synthesis and investigation of anti-inflammatory activity of new thiourea derivatives of naproxen. Pharmaceuticals. 2023;16(5):666.
  6. Nedeljković N, Nikolić M, Čanović P, Zarić M, Živković Zarić R, Bošković J et al. Synthesis, characterization, and investigation of anti-inflammatory and cytotoxic activities of novel thiourea derivatives of naproxen. Pharmaceutics. 2023;16(1):1.
  7. Lipinski CA. Lead- and drug-like compounds: the rule-offive revolution. Adv Drug Deliv Rev. 2004;56(1):3–26.
  8. Varma MV, Ashokraj Y, Dixit R, Tennikova TB. Physicochemical determinants of intestinal absorption. Pharm Res. 2010;27(12):2828–36.
  9. Molero-Monfort M, Escuder-Gilabert L, Villanueva-Camañas RM, Sagrado S, Medina-Hernández MJ. Biopartitioning micellar chromatography: an in vitro technique for predicting human drug absorption. J Chromatogr B. 2001;753(2):225–36.
  10. Čudina O, Marković B, Karljiković-Rajić K, Vladimirov S. Biopartitioning micellar chromatography-partition coefficient micelle/water as a potential descriptor for hydrophobicity in prediction of oral drug absorption. Anal Lett. 2012;45(7):677–88.
  11. Stępnik KE, Malinowska I. Biopartitioning micellar chromatography and immobilized artificial membrane chromatography for predicting blood-brain barrier penetration of phenols. J Chromatogr A. 2013;1286:127–36.
  12. Dobričić V, Nikolić K, Vladimirov S, Čudina O. Biopartitioning micellar chromatography as a predictive tool for skin and corneal permeability. Eur J Pharm Sci. 2014;56:105–12.
  13. Héberger K. Quantitative structure-chromatographic retention relationships. J Chromatogr A. 2007;1158(1–2): 273–305.
  14. Kaliszan R, Marini F, Bączek T. Structure-retention relationships in chromatography. J Chromatogr A. 2007;1158(1–2):1–26.
  15. Dobričić V, Nikolic K, Vladimirov S, Čudina O. Biopartitioning micellar chromatography as a predictive tool for skin and corneal permeability of newly synthesized 17β-carboxamide steroids. Eur J Pharm Sci. 2014;56:105–12.
  16. Tsopelas F, Danias P, Pappa A, Tsantili-Kakoulidou A. Biopartitioning micellar chromatography under different conditions: Insight into the retention mechanism and the potential to model biological processes. J Chromatogr A. 2020;1621:461027.
  17. Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, et al.Gaussian Inc., Wallingford CT, 2010.
  18. Alvascience, alvaDesc (software for molecular descriptors calculation) version 2.0.8, https://www.alvascience.com, 2021.
  19. Statistica, version 13; TIBCO Software Inc., Palo Alto, USA, 2018.
  20. Arunyanart M, Love LJC. Model for Micellar Effects on Liquid Chromatography Capacity Factors and for Determination of Micelle-Solute Equilibrium Constants. Anal Chem. 1984;56,1557–61.
  21. Nedeljković N, Dobričić V, Vesović M, Jelić R, Marković B, Vujić Z, Nikolić M. In Vitro Pharmacokinetic Profiling of Thiourea Derivatives of Naproxen With Anti‐Inflammatory and Anticancer Activity. Chem. Biodivers. 2026;23(1):e02219.
  22. Molecular Descriptors, QSAR, Chemometrics and Chemoinformatics. Dragon Molecular Descriptor List.2013.
  23. Duchowicz PR, Fernández M, Caballero J, Castro EA, FernándezFM. QSAR for non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorgan Med Chem. 2006;14:5876–89.
  24. Hancock T, Put R, Coomans D, Vander Heyden Y, Everingham Y. A performance comparison of modern statistical techniques for molecular descriptor selection and retention prediction in chromatographic QSRR studies. Chemometr Intell Lab Systems.2005;76:185–96.
  25. Todeschini R, Consonni V. Handbook of molecular descriptors. Wiley-VCH, Weinheim. 2000. doi: 10.1002/9783527613106
  26. Duchowicz PR, Fernandez M, Caballero J, Castro EA, Fernandez FM. QSAR for non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem. 2006;14:5876–89.
  27. Xu J, Wang L, Zhang H, Shen X, Liang G. Quantitative structure‐property relationships studies on free‐radical polymerization chain‐transfer constants for styrene. J Appl Polym Sci. 2012;123(1):356–64.
  28. Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem. 2002;45(12):2615–23.
  29. Azman M, Sabri AH, Anjani QK, Mustaffa MF, Hamid KA. Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery. Pharmaceuticals (Basel). 2022;15(8):975.
DOI: https://doi.org/10.2478/eabr-2026-0017 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)
Language: English
Page range: 167 - 172
Submitted on: Feb 11, 2026
Accepted on: Apr 13, 2026
Published on: Oct 24, 2026
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services

© 2026 Nikola Nedeljkovic, Vladimir Dobricic, Marina Vesovic, Stefan Gavrilovic, Zorica Vujic, Milos Nikolic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.