Table 1.
Effects of HBO treatment on echocardiographic parameters: interventricular septal wall thickness at end systole and end-diastole (IVSs and IVSd), left ventricular internal diameter at end-systole and end-diastole (LVIDs and LVIDs), left ventricular posterior wall thickness at endsystole and end-diastole (LVPWs and LVPWd), and fractional shortening (FS). CTRL: healthy control Gal-3KO mice; EAM: Gal-3KO mice with induced EAM; EAM+HBO: Gal-3KO mice with induced EAM and HBO treatment. Values are presented as means ± mean standard error (SE). Kruskal–Wallis H; Mann–Whitney U tests *p< 0.05 indicates statistical significant differences between groups #compared to CTRL, *compared to EAM.
| CTRL | EAM | EAM+HBO | |
|---|---|---|---|
| IVSd (cm) | 0.064±0.052 | 0.093±0.101 | 0.100±0.032 |
| LVIDd (cm) | 0.246±0.177 | 0.210±0.134 | 0.203±0.024* |
| LVPWd (cm) | 0.058±0.062 | 0.086±0.110 | 0.092±0.016 |
| IVSs (cm) | 0.145±0.034 | 0.141±0.013 | 0.161±0.039 |
| LVIDs (cm) | 0.090±0.037 | 0.137±0.017 | 0.097±0.047* |
| LVPWs (cm) | 0.103±0.023 | 0.080±0.024 | 0.107±0.020 |
| FS (%) | 63.9±2.241 | 43.6±5.51# | 52.5±4.84* |
Figure 1.
Effects of HBO treatment on EAM severity score (A), degree of degeneration and necrosis of cardiomyocytes (B), and degree of fibrosis (C). CTRL: healthy control Gal-3KO mice; EAM: Gal-3KO mice with induced EAM; EAM+HBO: Gal-3KO mice with induced EAM and HBO treatment. Values are presented as means ± mean standard error (SE). Independent Samples t test; One-Way ANOVA *p< 0.05 indicates statistical significant differences between groups.
Figure 2.
Representative images of hematoxylin/eosin (H&E) staining of paraffin embedded heart tissue sections. CTRL: healthy control Gal-3KO mice; EAM: Gal-3KO mice with induced EAM; EAM+HBO: Gal-3KO mice with induced EAM and HBO treatment. Original magnification 40×.