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Evaluation of Morphometric Parameters in PCOS Rats Treated with Standardized Aronia melanocarpa L. Extract and/or Metformin Cover

Evaluation of Morphometric Parameters in PCOS Rats Treated with Standardized Aronia melanocarpa L. Extract and/or Metformin

EABR. Experimental and Applied Biomedical Research
Volume 26 (2025): Issue 2 (June 2025)
By: Teodora Todorovic,  Vladimir Jakovljevic,  Maja Muric,  Jasmina Sretenovic,  Jovan Rudic,  Dusan Todorovic,  Nikola Jovic and  Jovana Joksimovic Jovic  
Open Access
|Dec 2025

Figures & Tables

Figure 1.

The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on body weight parameters. A – body weight; B –body weight gain; C – body length; D – body mass index; E – body fat. * Statistical significance at the level of p < 0.05 compared to PCOS group, ** Statistical significance at the level of p < 0.01 compared to PCOS group.
The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on body weight parameters. A – body weight; B –body weight gain; C – body length; D – body mass index; E – body fat. * Statistical significance at the level of p < 0.05 compared to PCOS group, ** Statistical significance at the level of p < 0.01 compared to PCOS group.

Figure 2.

The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on ovary weight and estrus cycle. A – ovary weight; ** Statistical significance at the level of p < 0.01 compared to PCOS group.
The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on ovary weight and estrus cycle. A – ovary weight; ** Statistical significance at the level of p < 0.01 compared to PCOS group.

Figure 3.

The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on morphometric parameters of adipocytes and ovary tissues. A - adipocyte area; B – adipocytes diameter; C - number of cystic follicles; D – number of corpora lutea ** Statistical significance at the level of p < 0.01 compared to PCOS group.
The influence of usage metformin and Aronia melanocarpa extract, as well as their combined treatment on morphometric parameters of adipocytes and ovary tissues. A - adipocyte area; B – adipocytes diameter; C - number of cystic follicles; D – number of corpora lutea ** Statistical significance at the level of p < 0.01 compared to PCOS group.
DOI: https://doi.org/10.2478/eabr-2023-0016 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
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Language: English
Page range: 169 - 178
Submitted on: Nov 4, 2023
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Accepted on: Dec 29, 2023
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Published on: Dec 31, 2025
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Polycystic ovary syndrome,
metformin,
aronia melanocarpa,
dehydroepiandrosterone,
antioxidants,
animal model,
rats
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other

© 2025 Teodora Todorovic, Vladimir Jakovljevic, Maja Muric, Jasmina Sretenovic, Jovan Rudic, Dusan Todorovic, Nikola Jovic, Jovana Joksimovic Jovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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