Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

Corovic, Kemal; Stojanovic, Bojan; Petrovic, Andjela; Stanisavljevic, Isidora; Maric, Veljko; Zdravkovic, Natasa; Jovanovic, Marina

doi:10.2478/eabr-2023-0006

Abstract

Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.

References

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):17-30.
Search in Google Scholar Back to article
Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756-70.
Search in Google Scholar Back to article
Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, et al. The metabolic syndrome. Endocr Rev. 2008;29(7):777-822.
Search in Google Scholar Back to article
Camby I, Le Mercier M, Lefranc F, Kiss R. Galectin-1: a small protein with major functions. Glycobiology. 2006;16(11):137R-57R.
Search in Google Scholar Back to article
Rabinovich GA, Iglesias MM, Modesti NM, Castagna LF, Wolfenstein-Todel C, Riera CM, et al. Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J Immunol. 1998;160(10):4831-40.
Search in Google Scholar Back to article
Markovic B, Jovanovic I, Volarevic V, Zdravkovic N, Jovanovic M, Marić V, et al. Potential inversely immunomodulatory roles of Galectin-1 and Galectin-3 in ulcerative colitis. Wulfenia. 2016;23:188-205.
Search in Google Scholar Back to article
Farooq W, Farwa U, Khan FR. The metabolic syndrome and inflammation: role of insulin resistance and increased adiposity. Oman Med J. 2015;30(2):100-3.
Search in Google Scholar Back to article
Fryk E, Silva VRR, Jansson PA. Galectin-1 in Obesity and Type 2 Diabetes. Metabolites. 2022;12(10).
Search in Google Scholar Back to article
Mansour AA, Krautter F, Zhi Z, Iqbal AJ, Recio C. The interplay of galectins-1, -3, and -9 in the immuneinflammatory response underlying cardiovascular and metabolic disease. Cardiovascular Diabetology. 2022;21(1):253.
Search in Google Scholar Back to article
Yorulmaz E, Adali G, Yorulmaz H, Ulasoglu C, Tasan G, Tuncer I. Metabolic syndrome frequency in inflammatory bowel diseases. Saudi J Gastroenterol. 2011;17(6):376-82.
Search in Google Scholar Back to article
Rezaianzadeh A, Namayandeh SM, Sadr SM. National Cholesterol Education Program Adult Treatment Panel III Versus International Diabetic Federation Definition of Metabolic Syndrome, Which One is Associated with Diabetes Mellitus and Coronary Artery Disease? Int J Prev Med. 2012;3(8):552-8.
Search in Google Scholar Back to article
Ikeya K, Hanai H, Sugimoto K, Osawa S, Kawasaki S, Iida T, et al. The Ulcerative Colitis Endoscopic Index of Severity More Accurately Reflects Clinical Outcomes and Long-term Prognosis than the Mayo Endoscopic Score. J Crohns Colitis. 2016;10(3):286-95.
Search in Google Scholar Back to article
Pabla BS, Schwartz DA. Assessing Severity of Disease in Patients with Ulcerative Colitis. Gastroenterol Clin North Am. 2020;49(4):671-88.
Search in Google Scholar Back to article
Vespa E, D’Amico F, Sollai M, Allocca M, Furfaro F, Zilli A, et al. Histological Scores in Patients with Inflammatory Bowel Diseases: The State of the Art. J Clin Med. 2022;11(4).
Search in Google Scholar Back to article
Jovanovic M, Gajovic N, Jurisevic M, Markovic B, Marić V, Jovanovic M, et al. Fecal sST2 correlates with disease severity of ulcerative colitis. Vojnosanitetski pregled. 2018;76:26-.
Search in Google Scholar Back to article
Jovanovic M, Simovic Markovic B, Gajovic N, Jurisevic M, Djukic A, Jovanovic I, et al. Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression. World J Gastroenterol. 2019;25(43):6465-82.
Search in Google Scholar Back to article
Yu X, Qian J, Ding L, Yin S, Zhou L, Zheng S. Galectin- 1: A Traditionally Immunosuppressive Protein Displays Context-Dependent Capacities. Int J Mol Sci. 2023;24(7).
Search in Google Scholar Back to article
Acar S, Paketçi A, Küme T, Tuhan H, Gürsoy Çalan Ö, Demir K, et al. Serum galectin-1 levels are positively correlated with body fat and negatively with fasting glucose in obese children. Peptides. 2017;95:51-6.
Search in Google Scholar Back to article
Fryk E, Sundelin JP, Strindberg L, Pereira MJ, Federici M, Marx N, et al. Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin- 1 in type 2 diabetes patients. Metabolism. 2016;65(7): 998-1006.
Search in Google Scholar Back to article
Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y, et al. Proteomics-based identification of differentiallyexpressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. J Proteome Res. 2009;8(3):1255-62.
Search in Google Scholar Back to article
Liu FT, Stowell SR. The role of galectins in immunity and infection. Nat Rev Immunol. 2023:1-16.
Search in Google Scholar Back to article
D’Haene N, Sauvage S, Maris C, Adanja I, Le Mercier M, Decaestecker C, et al. VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3- induced angiogenesis. PLoS One. 2013;8(6):e67029.
Search in Google Scholar Back to article
Suzuki O, Abe M. Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: regulatory roles of cell surface glycans. Int J Oncol. 2014;44(5):1433-42.
Search in Google Scholar Back to article
Almkvist J, Karlsson A. Galectins as inflammatory mediators. Glycoconj J. 2002;19(7-9):575-81.
Search in Google Scholar Back to article
Stowell SR, Qian Y, Karmakar S, Koyama NS, Dias- Baruffi M, Leffler H, et al. Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion1. The Journal of Immunology. 2008;180(5):3091-102.
Search in Google Scholar Back to article
Allione A, Wells V, Forni G, Mallucci L, Novelli F. Beta-galactoside-binding protein (beta GBP) alters the cell cycle, up-regulates expression of the alpha- and beta-chains of the IFN-gamma receptor, and triggers IFN-gamma-mediated apoptosis of activated human T lymphocytes. J Immunol. 1998;161(5):2114-9.
Search in Google Scholar Back to article
Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, et al. Amelioration of graft versus host disease by galectin-1. Clin Immunol. 2003;109(3): 295-307.
Search in Google Scholar Back to article
Sundblad V, Morosi LG, Geffner JR, Rabinovich GA. Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation. The Journal of Immunology. 2017;199(11):3721-30.
Search in Google Scholar Back to article
Offner H, Celnik B, Bringman TS, Casentini-Borocz D, Nedwin GE, Vandenbark AA. Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol. 1990;28(2):177-84.
Search in Google Scholar Back to article
Liu F-T, Rabinovich GA. Galectins: regulators of acute and chronic inflammation. Annals of the New York Academy of Sciences. 2010;1183(1):158-82.
Search in Google Scholar Back to article
Santucci L, Fiorucci S, Rubinstein N, Mencarelli A, Palazzetti B, Federici B, et al. Galectin-1 suppresses experimental colitis in mice. Gastroenterology. 2003;124(5):1381-94.
Search in Google Scholar Back to article
Muglia CI, Gobbi RP, Smaldini P, Delgado ML, Candia M, Zanuzzi C, et al. Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1. J Cell Physiol. 2016;231(7):1575-85.
Search in Google Scholar Back to article

Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

Abstract

Paradigm

My account