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Determination of NOx in Mainstream Cigarette Smoke, CORESTA Collaborative Study and Recommended Method Cover

Determination of NOx in Mainstream Cigarette Smoke, CORESTA Collaborative Study and Recommended Method

Open Access
|Dec 2025

Figures & Tables

Figure 1.

Z-Scores for NO for each lab under ISO non-intense and ISO intense smoking regimes. Where NI = non-intense regime and I = Intense regime; samples are denoted as A (KR 2R5F), B (KR 1R6F), and C (CM9). Lab code gaps reflect withdrawals following code assignment and prior to result submission.
Z-Scores for NO for each lab under ISO non-intense and ISO intense smoking regimes. Where NI = non-intense regime and I = Intense regime; samples are denoted as A (KR 2R5F), B (KR 1R6F), and C (CM9). Lab code gaps reflect withdrawals following code assignment and prior to result submission.

Figure 2.

Z-Scores for NOx for each lab under ISO non-intense and ISO intense smoking regimes. Where NI = non-intense regime and I = Intense regime; samples are denoted as A (KR 2R5F), B (KR 1R6F), and C (CM9). Lab code gaps reflect withdrawals following code assignment and prior to result submission.
Z-Scores for NOx for each lab under ISO non-intense and ISO intense smoking regimes. Where NI = non-intense regime and I = Intense regime; samples are denoted as A (KR 2R5F), B (KR 1R6F), and C (CM9). Lab code gaps reflect withdrawals following code assignment and prior to result submission.

Smoking regimes and key parameters_

RegimeMachine parametersVent blocking
‘Non-Intense’
ISO 3308Puff volume: 35 mLPuff frequency: 1/60 sPuff duration: 2 sNone
‘Intense’
ISO 20778Puff volume: 55 mLPuff frequency: 1/30 sPuff duration: 2 s100%

Study test articles_

Sample IDDescriptionKey design description aApproximate TPM ISO 3308 b (mg/cig, t.p.)Approximate TPM ISO 20778 b (mg/cig, t.p.)
AKR 2R5FAmerican BlendPT: 30%Burley: 23%Tobacco: 540 mg/cigTotal ventilation: 69%2.428
BKR 1R6FAmerican BlendPT: 10%Burley: 22%Tobacco: 625 mg/cigTotal ventilation: 33%1039
CCM9Virginia TobaccoPT: 0%Burley: 0%Tobacco: 980 mg/cigTotal ventilation: 0%1742

Participating laboratories_

Name of participant
China National Tobacco Corp., Beijing Cigarette Factory Borgwaldt KC GmbH (now Körber)
Enthalpy Analytical
Japan Tobacco Inc.
JT International, Ökolab
KT&G Research Institute
Labstat International Inc.
Philip Morris International Brazil
Philip Morris International Indonesia
Philip Morris International Switzerland
Reemtsma Cigarettenfabriken GmbH - Imperial Brands
Souza Cruz SA, BAT

Estimated r and R Limits_ Weighted to represent 20 cigarettes for non-intense smoking and 10 cigarettes for intense smoking for one replicate_

SampleMeanN data sets arr (%)RR (%)
NO Non-Intense (μg/cig)
A64135.38.217.427.2
B153139.76.323.015.1
C64133.85.916.625.9
NO Intense (μg/cig)
A3231328.38.866.920.7
B3691326.47.180.921.9
C131129.77.465.049.7
NOx Non-Intense (μg/cig)
A71136.08.626.337.3
B1771311.86.734.819.7
C77134.96.319.425.3
NOx Intense (μg/cig)
A3861334.08.883.421.6
B4371330.47.088.520.2
C1541212.17.972.146.9
Language: English
Page range: 222 - 229
Submitted on: Apr 30, 2025
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Accepted on: Jul 17, 2025
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Published on: Dec 29, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Rana Tayyarah, Leona R. Sirkisoon, Michael J. Morton, Aidan M. Walker, Thomas Schmidt, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License.