Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
The results of outlier detection_
| Sample | Method | Lab code a | |||
|---|---|---|---|---|---|
| Overallb | Pad+Pad | ||||
| ISO non-intense | ISO intense | ISO non-intense | ISO intense | ||
| CM9 | Cochran | 3 | 3, 12 | 8b | 8a |
| Grubbs | |||||
| KR 1R6F | Cochran | 3, 8b | 3 | 8b | 8a |
| Grubbs | |||||
| KR 2R5F | Cochran | 12 | 12, 8a | 8b | 8a |
| Grubbs | 8b, 15 | ||||
| Sample 1 | Cochran | 1 | 12, 8a | 1 | 8a |
| Grubbs | |||||
| Sample 2 | Cochran | 2, 12 | 8a | 2 | 8a |
| Grubbs | |||||
| Sample 3 | Cochran | 12, 8b | 12, 7 | 8b | 7 |
| Grubbs | |||||
| Sample 4 | Cochran | 8b | 9, 8a | 8b | 9 |
| Grubbs | 15 | 8b, 15 | |||
Repeatability (r) and Reproducibility (R) for hydrogen cyanide (μg/cig) under ISO non-intense smoking regime_
| Sample | Method | N of data | Mean | r | r(%) a | R | R(%) b |
|---|---|---|---|---|---|---|---|
| CM9 | Overall c | 21 | 139.34 | 12.33 | 8.85 | 26.69 | 19.15 |
| P+P d | 16 | 140.74 | 11.18 | 7.94 | 25.01 | 17.77 | |
| P+Ie | 5 | 134.84 | 18.04 | 13.38 | 30.24 | 22.42 | |
| KR 1R6F | Overall | 19 | 95.67 | 11.47 | 11.99 | 16.92 | 17.69 |
| P+P | 15 | 96.41 | 9.31 | 9.65 | 15.90 | 16.50 | |
| P+I | 5 | 93.97 | 22.97 | 24.44 | 23.74 | 25.27 | |
| KR 2R5F | Overall | 19 | 12.82 | 2.56 | 19.98 | 4.14 | 32.30 |
| P+P | 15 | 12.95 | 2.55 | 19.67 | 3.97 | 30.64 | |
| P+I | 4 | 13.81 | 3.26 | 23.60 | 9.45 | 68.40 | |
| Sample 1 | Overall | 20 | 26.96 | 4.29 | 15.93 | 7.99 | 29.63 |
| P+P | 16 | 26.41 | 4.04 | 15.28 | 7.00 | 26.49 | |
| P+I | 4 | 29.11 | 5.17 | 17.77 | 9.45 | 32.45 | |
| Sample 2 | Overall | 19 | 53.54 | 7.46 | 13.94 | 11.54 | 21.56 |
| P+P | 16 | 52.98 | 7.95 | 15.00 | 11.52 | 21.74 | |
| P+I | 4 | 59.82 | 7.21 | 12.06 | 20.95 | 35.02 | |
| Sample 3 | Overall | 19 | 83.50 | 8.77 | 10.50 | 19.86 | 23.79 |
| P+P | 16 | 84.09 | 9.20 | 10.94 | 20.13 | 23.94 | |
| P+I | 4 | 81.83 | 18.45 | 22.55 | 23.62 | 28.86 | |
| Sample 4 | Overall | 19 | 103.54 | 11.01 | 10.63 | 17.18 | 16.59 |
| P+P | 16 | 103.95 | 11.40 | 10.96 | 18.17 | 17.47 | |
| P+I | 4 | 95.63 | 13.30 | 13.91 | 34.79 | 36.38 |
Mean total hydrogen cyanide (μg/cig) yields in mainstream smoke under ISO non-intense smoking regime_
| Sample | Overall a | Pad+Pad | Pad+Imp | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Stdev b | RSD(%) c | Mean | Stdev | RSD(%) | Mean | Stdev | RSD(%) | |
| CM9 | 139.34 | 9.29 | 6.67 | 140.74 | 8.66 | 6.15 | 134.84 | 10.10 | 7.49 |
| KR 1R6F | 95.67 | 5.91 | 6.18 | 96.41 | 5.52 | 5.73 | 93.97 | 8.35 | 8.89 |
| KR 2R5F | 12.82 | 1.44 | 11.27 | 12.95 | 1.38 | 10.66 | 13.81 | 3.02 | 21.83 |
| Sample 1 | 26.96 | 2.78 | 10.32 | 26.41 | 2.43 | 9.21 | 29.11 | 3.08 | 10.59 |
| Sample 2 | 53.54 | 4.03 | 7.53 | 52.98 | 4.02 | 7.58 | 59.82 | 6.68 | 11.17 |
| Sample 3 | 83.50 | 6.90 | 8.27 | 84.09 | 6.97 | 8.29 | 81.83 | 8.00 | 9.78 |
| Sample 4 | 103.54 | 6.00 | 5.79 | 103.95 | 6.32 | 6.08 | 95.63 | 11.14 | 11.65 |
Mean total hydrogen cyanide (μg/cig) yields in mainstream smoke under ISO intense smoking regime_
| Sample | Overall a | Pad+Pad | Pad+Imp | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Stdev b | RSD(%) c | Mean | Stdev | RSD(%) | Mean | Stdev | RSD(%) | |
| CM9 | 302.70 | 17.95 | 5.93 | 305.63 | 16.43 | 5.38 | 319.12 | 40.27 | 12.62 |
| KR 1R6F | 394.90 | 35.18 | 8.91 | 399.01 | 31.30 | 7.85 | 402.66 | 35.26 | 8.76 |
| KR 2R5F | 377.04 | 19.31 | 5.12 | 371.43 | 27.15 | 7.31 | 362.74 | 44.46 | 12.26 |
| Sample 1 | 324.66 | 28.28 | 8.71 | 327.29 | 26.60 | 8.13 | 316.93 | 35.32 | 11.14 |
| Sample 2 | 337.91 | 29.68 | 8.78 | 338.69 | 31.24 | 9.22 | 334.67 | 22.49 | 6.72 |
| Sample 3 | 265.71 | 22.55 | 8.49 | 269.24 | 21.48 | 7.98 | 259.32 | 31.29 | 12.07 |
| Sample 4 | 248.68 | 11.75 | 4.73 | 245.89 | 16.08 | 6.54 | 233.99 | 23.52 | 10.05 |
Participating laboratories and institutions_
| Name of participants |
|---|
| BATB Regulatory Analysis Laboratory |
| Beijing Cigarette Factory Company, Ltd., Shanghai Tobacco Group |
| Beijing Tobacco Quality Supervision and Inspection Station |
| China National Tobacco Quality Supervision and Test Center |
| China Tobacco Anhui Industrial Co., Ltd. |
| China Tobacco Chongqing Industrial Co., Ltd. |
| China Tobacco Fujian Industrial Co., Ltd. |
| China Tobacco Gansu tobacco Industrial Co., Ltd. |
| China Tobacco Guangxi Industrial Co., Ltd. |
| China Tobacco Guizhou Industrial Co., Ltd. |
| China Tobacco Henan Industrial Co., Ltd. |
| China Tobacco Jiangxi Industrial Co., Ltd. |
| China Tobacco Sichuan Industrial Co., Ltd. |
| China Tobacco Zhejiang Industrial Co., Ltd. |
| Global Laboratory Services |
| KT&G Research Institute |
| MP C.I.T. Montepaz S.A. |
| Yunnan Tobacco Quality Supervision and Inspection Station |
Study samples_
| Sample | Description | ISO 3308 “tar” level (mg/cig) |
|---|---|---|
| KR 2R5F | American blend | 1 |
| Sample 1 | American blend – charcoal filter | 3 |
| Sample 2 | American blend – charcoal filter | 5 |
| KR 1R6F | American blend | 8 |
| Sample 3 | Virginia blend | 8 |
| Sample 4 | Virginia blend | 11 |
| CM9 | Virginia blend | 16 |
Repeatability (r) and Reproducibility (R) for hydrogen cyanide (μg/cig) under ISO intense smoking regime_
| Sample | Method | N of data | Mean | r | r(%) a | R | R(%) b |
|---|---|---|---|---|---|---|---|
| CM9 | Overall c | 20 | 302.70 | 27.53 | 9.09 | 51.53 | 17.02 |
| P+P d | 16 | 305.63 | 26.26 | 8.59 | 47.30 | 15.48 | |
| P+Ie | 5 | 319.12 | 71.50 | 22.41 | 120.59 | 37.79 | |
| KR 1R6F | Overall | 20 | 394.90 | 44.49 | 11.27 | 101.16 | 25.62 |
| P+P | 15 | 399.01 | 37.42 | 9.38 | 90.60 | 22.71 | |
| P+I | 5 | 402.66 | 66.89 | 16.61 | 105.06 | 26.09 | |
| KR 2R5F | Overall | 16 | 377.04 | 27.66 | 7.34 | 55.69 | 14.77 |
| P+P | 15 | 371.43 | 31.25 | 8.41 | 78.60 | 21.16 | |
| P+I | 4 | 362.74 | 78.49 | 21.64 | 135.60 | 37.38 | |
| Sample 1 | Overall | 19 | 324.66 | 28.10 | 8.66 | 81.54 | 25.11 |
| P+P | 16 | 327.29 | 27.71 | 8.47 | 76.94 | 23.51 | |
| P+I | 4 | 316.93 | 59.27 | 18.70 | 108.17 | 34.13 | |
| Sample 2 | Overall | 20 | 337.91 | 35.90 | 10.63 | 85.39 | 25.27 |
| P+P | 16 | 338.69 | 36.18 | 10.68 | 90.30 | 26.66 | |
| P+I | 4 | 337.93 | 61.11 | 18.08 | 77.58 | 22.96 | |
| Sample 3 | Overall | 19 | 265.71 | 23.68 | 8.91 | 65.00 | 24.46 |
| P+P | 16 | 269.24 | 23.88 | 8.87 | 62.12 | 23.07 | |
| P+I | 4 | 259.32 | 51.43 | 19.83 | 96.00 | 37.02 | |
| Sample 4 | Overall | 17 | 248.68 | 21.97 | 8.84 | 33.71 | 13.56 |
| P+P | 16 | 245.89 | 26.55 | 10.80 | 46.26 | 18.81 | |
| P+I | 4 | 233.99 | 17.52 | 7.49 | 74.31 | 31.76 |