Have a personal or library account? Click to login
Robustness of HPHC Reduction in THS 2.2 Aerosol Relative to 3R4F Reference Cigarette Smoke under Extreme Climatic Conditions Cover

Robustness of HPHC Reduction in THS 2.2 Aerosol Relative to 3R4F Reference Cigarette Smoke under Extreme Climatic Conditions

Open Access
|Jul 2021

References

  1. Bentley, M. and S. Maeder: Quantification of HPHCs in ENDP Aerosols; in Toxicological Evaluation of Electronic Nicotine Delivery Products. Chapter 4; edited by M.C. Peitsch and J. Hoeng, Academic Press, Cambridge, Massachusetts, USA, 2021, pp 41–81. DOI: 10.1016/B978-0-12-820490-0.00004-3
  2. Boué, S., W.K. Schlage, D. Page, J. Hoeng, and M.C. Peitsch: Toxicological Assessment of Tobacco Heating System 2.2: Findings from an Independent Peer Review; Regul. Toxicol. Pharmacol. 104 (2019) 115–127. DOI: 10.1016/j.yrtph.2019.03.007
  3. Kogel, U., B. Titz, W.K. Schlage, C. Nury, F. Martin, A. Oviedo, S. Lebrun, A. Elamin, E. Guedj, K. Trivedi, N.V. Ivanov, P. Vanscheeuwijck, M.C. Peitsch, and J. Hoeng: Evaluation of the Tobacco Heating System 2.2. Part 7: Systems Toxicological Assessment of a Mentholated Version Revealed Reduced Cellular and Molecular Exposure Effects Compared with Mentholated and Non-Mentholated Cigarette Smoke; Regul. Toxicol. Pharmacol. 81 Suppl. 2 (2016) S123–S138. DOI: 10.1016/j.yrtph.2016.11.001
  4. Lüdicke, F., G. Baker, J. Magnette, P. Picavet, and R. Weitkunat: Reduced Exposure to Harmful and Potentially Harmful Smoke Constituents with the Tobacco Heating System 2.1; Nicotine Tob. Res. 19 (2016) 168–175. DOI: 10.1093/ntr/ntw164
  5. Lüdicke, F., C. Haziza, R. Weitkunat, and J. Magnette: Evaluation of Biomarkers of Exposure in Smokers Switching to a Carbon-Heated Tobacco Product: A Controlled, Randomized, Open-Label 5-Day Exposure Study; Nicotine Tob. Res. 18 (2016) 1606–1613. DOI: 10.1093/ntr/ntw022
  6. Lüdicke, F., P. Picavet, G. Baker, C. Haziza, V. Poux, N. Lama, and R. Weitkunat: Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1); Nicotine Tob. Res. 20 (2017) 161–172. DOI: 10.1093/ntr/ntw287
  7. Martin, F., M. Talikka, N.V. Ivanov, C. Haziza, J. Hoeng, and M.C. Peitsch: Evaluation of the Tobacco Heating System 2.2. Part 9: Application of Systems Pharmacology to Identify Exposure Response Markers in Peripheral Blood of Smokers Switching to THS 2.2; Regul. Toxicol. Pharmacol. 81 Suppl. 2 (2016) S151–S157. DOI: 10.1016/j.yrtph.2016.11.011
  8. Oviedo, A., S. Lebrun, U. Kogel, J. Ho, W.T. Tan, B. Titz, P. Leroy, G. Vuillaume, M. Bera, F. Martin, G. Rodrigo, M. Esposito, R. Dempsey, N.V. Ivanov, J. Hoeng, M.C. Peitsch, and P. Vanscheeuwijck: Evaluation of the Tobacco Heating System 2.2. Part 6: 90-Day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-Mentholated Cigarette Smoke; Regul. Toxicol. Pharmacol. 81 Suppl. 2 (2016) S93–S122. DOI: 10.1016/j.yrtph.2016.11.004
  9. Schaller, J.-P., D. Keller, L. Poget, P. Pratte, E. Kaelin, D. McHugh, G. Cudazzo, D. Smart, A.R. Tricker, L. Gautier, M. Yerly, R. Reis Pires, S. Le Bouhellec, D. Ghosh, I. Hofer, E. Garcia, P. Vanscheeuwijck, and S. Maeder: Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol; Regul. Toxicol. Pharmacol. 81 (2016) S27–S47. DOI: 10.1016/j.yrtph.2016.10.001
  10. Schaller, J.-P., J.P. Pijnenburg, A. Ajithkumar, and A.R. Tricker: Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the Tobacco Blend on the Formation of Harmful and Potentially Harmful Constituents of the Tobacco Heating System 2.2 Aerosol; Regul. Toxicol. Pharmacol. 81 (2016) S48–S58. DOI: 10.1016/j.yrtph.2016.10.016
  11. Smith, M.R., B. Clark, F. Lüdicke, J.-P. Schaller, P. Vanscheeuwijck, J. Hoeng, and M.C. Peitsch: Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program; Regul. Toxicol. Pharmacol. 81 (2016) S17–S26. DOI: 10.1016/j.yrtph.2016.07.006
  12. Wong, E.T., U. Kogel, E. Veljkovic, F. Martin, Y. Xiang, S. Boue, G. Vuillaume, P. Leroy, E. Guedj, G. Rodrigo, N.V. Ivanov, J. Hoeng, M.C. Peitsch, and P. Vanscheeuwijck: Evaluation of the Tobacco Heating System 2.2. Part 4: 90-Day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects Compared with Cigarette Smoke; Regul. Toxicol. Pharmacol. 81 Suppl. 2 (2016) S59–S81. DOI: 10.1016/j.yrtph.2016.10.015
  13. Zha, Q. and S. Moldoveanu: The Influence of Cigarette Moisture to the Chemistry of Particulate Phase Smoke of a Common Commercial Cigarette; Beitr. Tabakforsch. Int. 21 (2004) 184–191. DOI: 10.2478/cttr-2013-0779
  14. International Organization for Standardization (ISO): ISO 3402:1999: Tobacco and Tobacco Products – Atmosphere for Conditioning and Testing; ISO, Geneva, Switzerland, 2015.
  15. World Health Organization (WHO): Stability Testing of Active Pharmaceutical Ingredients and Finished Pharmaceutical Products; Annex 2, WHO Technical Report Series 953 (2009) 87–123. Available at: http://digicollection.org/hss/documents/s19133en/s19133en.pdf (accessed April, 2021)
  16. Goujon, C., S. Kleinhans, S. Maeder, L. Poget, and J.-P. Schaller: Robustness of HPHC Reduction for THS 2.2 Aerosol Compared with 3R4F Reference Cigarette Smoke Under High Intensity Puffing Conditions; Beitr. Tabakforsch. Int. 29 (2020) 66–83. DOI: 10.2478/cttr-2020-0008
  17. Djordjevic, M.V., S.D. Stellman, and E. Zang: Doses of Nicotine and Lung Carcinogens Delivered to Cigarette Smokers; J. Natl. Cancer Inst. 92 (2000) 106–111. DOI: 10.1093/jnci/92.2.106
  18. World Health Organization (WHO): WHO Study Group on Tobacco Product Regulation: Report on the Scientific Basis of Tobacco Product Regulation, Fifth Report, WHO Technical Report Series 989 (2015). Available at: https://escholarship.org/content/qt81m4m677/qt81m4m677.pdf (accessed April, 2021)
  19. Poget, L., P. Campelos, C. Jeannet, and S. Maeder: Development of Models for the Estimation of Mouth Level Exposure to Aerosol Constituents from a Heat-Not-Burn Tobacco Product Using Mouthpiece Analysis; Beitr. Tabakforsch. Int. 27 (2017) 42–64. DOI : 10.1515/cttr-2017-0005
  20. Chen, Z., Q. Miao, J. Zhao, L. Ding, Y. Xiao, H. Wang, Y. Qin, W. Xiong, H. Tao, Y. Wang, X. Lv, and Q. Feng: Conditioning of Tobacco and Tobacco Products: The Effect of Forced Air Flow; Beitr. Tabakforsch. Int. 28 (2019) 224–229. DOI: 10.2478/cttr-2019-0003
  21. Government of Canada: Canadian Tobacco Reporting Regulations: 2000-07-19 Canada Gazette Part II, Vol. 134, No. 15 Part 3: Emissions from Designated Tobacco Products. Available at: http://www.hc-sc.gc.ca/hl-vs/tobac-tabac/legislation/reg/indust/index_e.html (accessed April, 2021).
  22. International Organization for Standardization (ISO): ISO/IEC 17025:2005: General Requirements for the Competence of Testing and Calibration Laboratories; ISO, Geneva, Switzerland, 2017.
  23. Gelman, A., J.B. Carlin, H.S. Stern, D.B. Dunson, A. Vehtari, and D.B. Rubin: Bayesian Data Analysis; Third Edition, Chapman and Hall, CRC Press, 2013. Available at: https://statisticalsupportandresearch.files.wordpress.com/2017/11/bayesian_data_analysis.pdf (accessed May, 2021)
  24. Kruschke, J.: Doing Bayesian Data Analysis: A Tutorial with R, JAGS, and Stan; 2nd Edition, Academic Press, Cambridge, Massachusetts, USA, 2014. ISBN: 9780124059160
  25. Robert, C.P. and G. Casella: Introducing Monte Carlo Methods with R; Springer, New York, NY, USA, 2010, Vol. 18. ISBN: 978-1-4419-1576-4
  26. Littell, R.C., G.A. Milliken, W.W. Stroup, R.D. Wolfinger, and O. Schabenberger: SAS® for Mixed Models; SAS Institute, Cary, NC, USA, 2006. ISBN: 159047-500-3
  27. West, B.T., K.B. Welch, and A.T. Galecki: Linear Mixed Models: A Practical Guide Using Statistical Software, 2nd Edition; Chapman and Hall/CRC Press, Boca Raton, FL, USA, 2014. ISBN 9781466560994
Language: English
Page range: 109 - 126
Submitted on: Dec 4, 2020
Accepted on: Mar 30, 2021
Published on: Jul 17, 2021
Published by: Institut für Tabakforschung GmbH
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Laurent Poget, Catherine Goujon, Samuel Kleinhans, Serge Maeder, Jean-Pierre Schaller, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License.