Plasma Microrna Profiling in Overweight and Obese Pregnant Women: An Exploratory Pooled-Sample Study
References
- World Health Organization. Obesity and overweight. Updated December 8, 2025. Accessed August 3, 2026.
- Frederick IO, Rudra CB, Miller RS, Foster JC, Williams MA. Adult weight change, weight cycling, and prepregnancy obesity in relation to risk of preeclampsia. Epidemiology. 2006;17(4):428–434.
- Smith GCS, Shah I, Pell JP, Crossley JA, Dobbie R. Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort study. Am J Public Health. 2007;97(1):157–162.
- Slack E, Best KE, Rankin J, Heslehurst N. Maternal obesity classes, preterm and post-term birth: a retrospective analysis of 479,864 births in England. BMC Pregnancy Childbirth. 2019;19(1):434.
- Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15(8):509–524.
- Macfarlane LA, Murphy PR. MicroRNA: biogenesis, function and role in cancer. Curr Genomics. 2010;11(7):537–561.
- Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ et al. The microRNA spectrum in 12 body fluids. Clin Chem. 2010;56(11):1733–1741.
- Toljic M, Nikolic N, Joksic I, Carkic J, Munjas J, Karadzov Orlic N et al. Expression of miRNAs and proinflammatory cytokines in pregnant women with gestational diabetes mellitus. J Reprod Immunol. 2024; 162:104211.
- Wander PL, Boyko EJ, Hevner K, Parikh VJ, Tadesse MG, Sorensen TK et al. Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes. Diabetes Res Clin Pract. 2017; 132:1–9.
- Yoffe L, Polsky A, Gilam A, Raff C, Mecacci F, Ognibene A et al. Early diagnosis of gestational diabetes mellitus using circulating microRNAs. Eur J Endocrinol. 2019;181(5):565–577.
- Landrier JF, Derghal A, Mounien L. MicroRNAs in obesity and related metabolic disorders. Cells. 2019;8(8):859.
- Carreras-Badosa G, Bonmatí A, Ortega FJ, Mercader JM, Guindo-Martínez M, Torrents D et al. Altered circulating miRNA expression profile in pregestational and gestational obesity. J Clin Endocrinol Metab. 2015;100(11): E1446–E1456.
- Enquobahrie DA, Wander PL, Tadesse MG, Qiu C, Holzman C, Williams MA. Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy. Obes Res Clin Pract. 2017;11(4):464–474.
- Thibeault K, Légaré C, Desgagné V, White F, Hivert MF, Bouchard L. Maternal body mass index is associated with profile variation in circulating micro-RNAs at first trimester of pregnancy. Biomedicines. 2022;10(7):1726.
- Serati A, Novielli C, Anelli GM, Paleari R, Mandò C. Characterization of maternal circulating microRNAs in obese pregnancies and gestational diabetes mellitus. Antioxidants (Basel). 2023;12(2):515.
- Mavreli D, Lykoudi A, Lambrou G, Papaioannou G, Vrachnis N, Kalantaridou S et al. Deep sequencing identified dysregulated circulating microRNAs in late-onset preeclampsia. In Vivo. 2020;34(5):2317–2324.
- Ura B, Feriotto G, Monasta L, Bilel S, Zweyer M, Celeghini C. Potential role of circulating microRNAs as early markers of preeclampsia. Taiwan J Obstet Gynecol. 2014;53(2):232–234.
- Koleva L, Spasova V, Popova M, Petkova V, Dimitrov M. Obesity in pregnancy—implications on pregnancy events. Open Access Maced J Med Sci. 2020;8(B):1157–1161.
- Kolkova Z, Holubekova V, Grendar M, Nachajova M, Zubor P, Pribulova T et al. Association of circulating miRNA expression with preeclampsia, its onset, and severity. Diagnostics (Basel). 2021;11(3):476.
DOI: https://doi.org/10.2478/bjmg-2026-0012 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160
Language: English
Page range: 1 - 6
Published on: Oct 14, 2026
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Related subjects:
© 2026 V Spasova, D Hristova, B Rukova, L Koleva, M Vladimirov, A Kolev, D Koleva, O Antonova, B Karamishev, S Hadzhidekova, K Karamisheva, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution 4.0 License.