Have a personal or library account? Click to login

G Protein-Coupled Receptor 35 Holds Potential as a Beacon of Hope for Treating Chondrosarcoma

By:
A Tuncal and  R Kalkan  
Open Access
|Oct 2025

References

  1. Hogendoorn PCW, Bovée JVMG, Nielsen GP. Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma. In: Fletcher CD, Bridge JA, Hogendoorn PCW, Mertens F, eds. World Health Organization Classification of Tumours of Soft Tissue and Bone. 5th ed. Vol 5. Lyon, France: IARC Press; 2013:264–268.
  2. Fletcher CD, Bridge JA, Hogendoorn PCW, Mertens F, eds. WHO Classification of Tumours of Soft Tissue and Bone: WHO Classification of Tumours, vol 5. 4th ed. Geneva, Switzerland: World Health Organization; 2013.
  3. Chow WA. Chondrosarcoma: biology, genetics, and epigenetics. F1000Res. 2018;7: F1000. doi:10.12688/f1000research.15953.1.
  4. Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, et al. Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma. Nat Genet. 2013;45(8):923–926. doi:10.1038/ng.2668.
  5. Dienstmann R, Rodon J, Serra V, Tabernero J. Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors. Mol Cancer Ther. 2014;13(4):1021–1031. doi: 10.1158/1535-7163.MCT-13-0639.
  6. Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, et al. Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: results of a non-comparative, randomised, double-blind, placebo-controlled, multicentre phase II study. Eur J Cancer. 2021; 150:108–118. doi: 10.1016/j.ejca.2021.03.039.
  7. Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, et al. Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. Mol Cancer Ther. 2014;13(7):1259–1269. doi: 10.1158/1535-7163.MCT-13-0731.
  8. RefSeq. Jul 2008. Available from: https://www.ncbi.nlm.nih.gov/refseq/
  9. Cybulski C, Górski B, Huzarski T, Masojć B, Mierzejewski M, Dębniak T, et al. CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet. 2004;75(6):1131–5. doi:10.1086/426403.
  10. DepMap, Broad. DepMap 22Q2 Public. figshare. Published 2022.
  11. Corsello SM, Nagari RT, Spangler RD, Rossen J, Kocak M, Bryan JG, et al. Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. Nat Cancer. 2020;1(2):235–248. doi:10.1038/s43018-019-0018-6.
  12. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603–607. doi:10.1038/nature11003.
  13. Daina A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 2019;47(W1):W357–W364. doi:10.1093/nar/gkz382.
  14. Daina A, Zoete V. Testing the predictive power of reverse screening to infer drug targets, with the help of machine learning. Commun Chem. 2024;7(1):105. doi:10.1038/s42004-024-01179-2.
  15. Napolitano F, Sirci F, Carrella D, di Bernardo D. Drug-set enrichment analysis: A novel tool to investigate drug mode of action. Bioinformatics. 2016;32(2):235–241. doi:10.1093/bioinformatics/btv536.
  16. Gfeller, D., Michielin, O., and Zoete, V. (2013). Shaping the interaction landscape of bioactive molecules. Bioinformatics 29(23), 3073–3079.
  17. Dermawan JKT, Nafa K, Mohanty A, Xu Y, Rijo I, Casanova J, et al. Distinct IDH1/2-associated methylation profile and enrichment of TP53 and TERT mutations distinguish dedifferentiated chondrosarcoma from conventional chondrosarcoma. Cancer Res Commun. 2023;33(4):431–443. doi: 10.1158/2767-9764.CRC-22-0397.
  18. Perez Almeria CV, Setiawan IM, Siderius M, Smit MJ. G protein-coupled receptors as promising targets in cancer. Curr Opin Endocrinol Metab. 2021;16(2):119–127. doi: 10.1016/j.coemr.2020.10.005.
  19. Insel PA, Sriram K, Salmerón C, Wiley SZ. Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets. Future Med Chem. 2020;12(6):523–532. doi:10.4155/fmc-2019-0357.
  20. Müller-Lissner S. Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013;9(4):391–401. doi:10.1517/17425255.2013.77 3972.
  21. Criddle DN. Reactive oxygen species, Ca(2+) stores and acute pancreatitis; a step closer to therapy? Cell Calcium. 2016;60(3):180–189. doi: 10.1016/j.ceca.2016.04.007.
  22. Ivanova H, Vervliet T, Missiaen L, Parys JB, De Smedt H, Bultynck G. Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival. Biochim Biophys Acta. 2014;1843(10):2164–2183. doi: 10.1016/j.bbamcr.2014.03.007.
  23. Dong J, Aulestia FJ, Kahn SA, Zeniou M, Dubois LG, El-Habr EA, et al. Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells: Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling. Biochim Biophys Acta Mol Cell Res. 2017;1864(6):1018–27. doi: 10.1016/j.bbamcr.2017.01.010.
  24. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, et al. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012;2(7):638–51. doi:10.1158/2159-8290.CD-12-0093.
  25. Feve M, Zeniou-Meyer M, Haiech J, Chneiweiss H, Kilhoffer CM, Mameri S. US patent application publication No. US 2014/0186872 A1. Published 2014.
  26. Grunewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, et al. Sarcoma treatment in the era of molecular medicine. EMBO Mol Med. 2020;12(11):e11131. doi:10.15252/emmm.201911131.
  27. Boehme KA, Schleicher SB, Traub F, Rolauffs B. Chondrosarcoma: A rare misfortune in aging human cartilage? The role of stem and progenitor cells in proliferation, malignant degeneration, and therapeutic resistance. Int J Mol Sci. 2018;19(1):311. doi:10.3390/ijms19010311.
  28. Menendez ST, Gallego B, Murillo D, Rodriguez A, Rodriguez R. Cancer stem cells as a source of drug resistance in bone sarcomas. J Clin Med. 2021;10(12):262. doi:10.3390/jcm10122621.
  29. Rey V, Tornín J, Alba-Linares JJ, Robledo C, Murillo D, Rodríguez A, et al. A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma. EBio-Medicine. 2024; 102:105090. doi: 10.1016/j.ebiom.2024.105090.
  30. Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, et al. Biology and management of high-grade chondrosarcoma: an update on targets and treatment options. Int J Mol Sci. 2023;24(2):1361. doi:10.3390/ijms24021361.
Language: English
Published on: Oct 8, 2025
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 times per year

© 2025 A Tuncal, R Kalkan, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.