Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
Figure 7.
Figure 8.
Figure 9.
Figure 10.
Figure 11.
Figure 12.
Figure 13.
Figure 14.
Figure 15.
Figure 16.
Figure 17.
Figure 18.
Details of 24 overlapping genes between ITP and MN
| TNF | ISG15 | KIF17 | KIAA0319L | PTAFR | PODN | LRP8 |
| WASF2 | FNDC5 | ALPL | RAB3B | HSPG2 | ESPN | PINK1 |
| EFHD2 | COL8A2 | PDPN | TRABD2B | TNFRSF25 | KCNQ4 | BSND |
| FOXE3 | EPHA2 | CLCNKB |
Details of 37 overlapping genes between ITP and IgAN
| NLRP3 | PC | WDR19 | NPHS2 | COL4A4 | IL1B | EPO |
| RUNX3 | IL1RN | FCGR2B | COL4A3 | CD14 | COL5A1 | CFB |
| PSMB8 | GTF2H5 | PROC | SFRP1 | IL33 | THSD7A | RAB3B |
| TNF | HFE | UNC13B | IL6R | INVS | HGF | LMX1B |
| IL4 | IKZF2 | PPARG | ROBO2 | REN | RARRES1 | PRDM16 |
| PLA2R1 |
PCR primer sequences for TNF, NLRP3, IL-1B, and β-actin
| TNF | F: CCTCTCTCTAATCAGCCCTCTG |
| NLRP3 | F: GATCTTCGCTGCGATCAACAG |
| IL-1B | F: TTCGACACATGGGATAACGAGG |
| β-actin | F: CATGTACGTTGCTATCCAGGC |
Highly connected DEG nodes identified in the PPI network
| Name of DEG | log2|FC| | P value | Number of connections |
|---|---|---|---|
| GAPDH | 3.2953409195274 | 2.19422420641149e-07 | 110 |
| TNF | 3.68646049371584 | 1.47314840083729e-10 | 105 |
| IL1B | 2.50243396726262 | 3.13683399045308e-12 | 75 |
| CD8A | 2.86640582723886 | 7.27565725241324e-06 | 71 |
| STAT3 | 2.09730201355131 | 4.96438557174655e-06 | 70 |
| UBA52 | 4.92834353505914 | 5.23423339042131e-08 | 63 |
| UBC | 2.18610712682655 | 1.05952355437303e-05 | 60 |
| RPS3 | 2.79618429621907 | 3.63790536504739e-08 | 56 |
| UBB | 3.82095799888894 | 4.31876503261331e-08 | 56 |
| CYCS | 2.29957812821002 | 5.45213130618771e-07 | 50 |
| CCL5 | 3.55169552386934 | 3.71390385817605e-09 | 49 |
| TYROBP | 5.2780755168582 | 5.38420777664558e-13 | 46 |
| COX4I1 | 2.09433418305494 | 4.71041649541531e-06 | 39 |
| H3-3B | 22.5682455453967 | 6.62776003598768e-07 | 39 |
| ISG15 | 3.35218542157055 | 3.0642442177228e-07 | 38 |
| TNFRSF1A | 3.60578976971292 | 1.90860747716885e-09 | 38 |
| CTSS | 3.17044562984854 | 8.53715947857592e-06 | 37 |
Details of 39 overlapping genes between ITP and CKD
| RPL22 | ISG15 | HPCA | FNDC5 | KIF1B | PADI3 | TP73 | PRDM16 | CHD5 |
| RUNX3 | EFHD2 | PINK1 | CNR2 | ALPL | CA6 | RS1 | PDPN | CORT |
| TNF | PTAFR | SYF2 | SLC45A1 | TRNP1 | VWA1 | TINAGL1 | HSPG2 | CLCNKB |
| FGR | TNFRSF25 | AGTRAP | PADI4 | PHACTR4 | ZNF683 | TRIM63 | GABRD | NMNAT1 |
| ESPN | NPPB | EPHA2 |