Figure 1.
Figure 2.
Figure 3.
Differentially expressed proteins identified in blood serum samples from children with АSD and healthy controla
| No | Protein name | Accession number | Gene name | Peptides (95%) | % Cov | Fold change |
|---|---|---|---|---|---|---|
| 1 | A disintegrin and metalloproteinase with thrombospondin motifs 13 (−) | Q76LX8 | ADAMTS13 | 8 | 6.5 | 0.78 |
| 2 | Angiogenin (−) | P03950 | ANG | 3 | 21.8 | 0.81 |
| 3 | Anthrax toxin receptor 2 (+) | P58335 | ANTXR2 | 5 | 16.6 | 1.41 |
| 4 | Apolipoprotein C-II (+) | P02655 | APOC2 | 4 | 49.5 | 1.26 |
| 5 | Apolipoprotein C-IV (+) | P55056 | APOC4 | 6 | 39.4 | 1.72 |
| 6 | Apolipoprotein F (+) | Q13790 | APOF | 2 | 6.7 | 1.30 |
| 7 | Apolipoprotein L1 (+) | O14791 | APOL1 | 15 | 40.6 | 1.40 |
| 8 | Apolipoprotein(a) − precursor (+) | P08519 | LPA/APOA | 13 | 3.7 | 1.75 |
| 9 | Basement membrane-specific heparan sulfate proteoglycan core protein (−) | P98160 | HSPG2 | 5 | 1.3 | 0.73 |
| 10 | Calponin-2 (−) | Q5RFN6 | CNN2 | 3 | 14.2 | 0.72 |
| 11 | Calsyntenin-1 (−) | O94985 | CLSTN1 | 3 | 3.8 | 0.75 |
| 12 | Carboxypeptidase N catalytic chain (−) | P15169 | CPN1 | 7 | 17.5 | 0.77 |
| 13 | Carboxypeptidase N subunit 2 (−) | P22792 | CPN2 | 12 | 28.1 | 0.80 |
| 14 | Chromogranin-A (−) | P10645 | CHGA | 5 | 13.1 | 0.66 |
| 15 | Complement C1q subcomponent subunit A (+) | P02745 | C1QA | 6 | 29 | 1.29 |
| 16 | Complement C4-A (+) | P0C0L4 | C4A | 1 | 62.3 | 7.36 |
| 17 | C-reactive protein (−) | P02741 | CRP | 6 | 23.7 | 0.83 |
| 18 | Extracellular matrix protein 1 (−) | Q16610 | ECM1 | 13 | 31.3 | 0.76 |
| 19 | Fibronectin 1 (−) | Q28275 | FN1 | 2 | 45.5 | 0.76 |
| 20 | Fibulin-5 (−) | Q9UBX5 | FBLN5 | 6 | 15.4 | 0.79 |
| 21 | Flavin reductase (+) | P30043 | BLVRB | 3 | 18.9 | 1.59 |
| 22 | Glia-derived nexin (−) | P07093 | SERPINE2 | 6 | 15.6 | 0.74 |
| 23 | Heparanase (−) | Q9Y251 | HPSE | 5 | 8.8 | 0.80 |
| 24 | Histone H1.3 (+) | P43277 | H1–3 | 2 | 13.6 | 1.39 |
| 25 | Histone H2B 1/2/3/4/6 (+) | P0C1H3 | H2B-I | 3 | 23 | 1.33 |
| 26 | Histone H4 (+) | Q6WV73 | H4 | 6 | 51.5 | 1.52 |
| 27 | Immunoglobulin heavy constant gamma 1 (+) | P01857 | IGHG1 | 1 | 36.5 | 1.40 |
| 28 | Immunoglobulin heavy constant gamma 2 (+) | P01859 | IGHG2 | 1 | 33.6 | 1.35 |
| 29 | Immunoglobulin heavy constant gamma 4 (+) | P01861 | IGHG4 | 3 | 21 | 1.63 |
| 30 | Immunoglobulin heavy variable 3–23 (−) | P01764 | IGHV3–23 | 2 | 26.1 | 0.46 |
| 31 | Immunoglobulin J chain (−) | P01591 | JCHAIN | 4 | 26.4 | 0.82 |
| 32 | Immunoglobulin kappa variable 1–5 (−) | P01602 | IGKV1–5 | 3 | 40.5 | 0.82 |
| 33 | Immunoglobulin kappa variable 3–20 (−) | P01619 | IGKV3–20 | 2 | 31.5 | 0.80 |
| 34 | Immunoglobulin lambda variable 3–1 (−) | P01715 | IGLV3–1 | 1 | 27.4 | 0.78 |
| 35 | Immunoglobulin lambda variable 3–21 (−) | P80748 | IGLV3–21 | 1 | 24.5 | 0.79 |
| 36 | Immunoglobulin lambda variable 3–25 (−) | P01717 | IGLV3–25 | 1 | 36.6 | 0.77 |
| 37 | Insulin-like growth factor-binding protein 5 (−) | P24593 | IGFBP5 | 1 | 3.7 | 0.76 |
| 38 | Intelectin-1 / Omentin (−) | Q8WWA0 | ITLN1 | 5 | 19.8 | 0.73 |
| 39 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (+) | P50213 | IDH3A | 1 | 2.7 | 1.41 |
| 40 | Kallistatin (+) | P29622 | SERPINA4 | 17 | 44.7 | 1.44 |
| 41 | Keratin, type I cytoskeletal 14 (−) | P02533 | KRT14 | 4 | 15.3 | 0.34 |
| 42 | Keratin, type I cytoskeletal 9 (−) | P35527 | KRT9 | 12 | 26.3 | 0.34 |
| 43 | Latent-transforming growth factor beta-binding protein 1 (−) | Q14766 | LTBP1 | 9 | 7.8 | 0.73 |
| 44 | Lipopolysaccharide-binding protein (+) | P18428 | LBP | 11 | 26.2 | 1.32 |
| 45 | Lipoprotein lipase (−) | P06858 | LPL | 4 | 13.3 | 0.70 |
| 46 | Mimecan (−) | P20774 | OGN | 6 | 13.8 | 0.80 |
| 47 | Myosin-9 (+) | P35579 | MYH9 | 13 | 8.7 | 1.47 |
| 48 | Nidogen-1 (−) | P14543 | NID1 | 11 | 10.1 | 0.69 |
| 49 | Periostin isoform 8 precursor (+) | Q15063 | POSTN | 17 | 28.8 | 1.21 |
| 50 | Plasma serine protease inhibitor (−) | P05154 | SERPINA5 | 12 | 30.3 | 0.77 |
| 51 | Plastin-2 (+) | P13796 | LCP1 | 10 | 19.1 | 1.37 |
| 52 | Platelet basic protein (−) | P02775 | PPBP | 7 | 45.3 | 0.77 |
| 53 | Platelet factor 4 variant (−) | P10720 | PF4V1 | 2 | 48.1 | 0.79 |
| 54 | Profilin-1 (+) | P07737 | PFN1 | 4 | 35.7 | 1.43 |
| 55 | Protein disulfide-isomerase A3 (−) | Q5RDG4 | PDIA3 | 4 | 8.1 | 0.67 |
| 56 | Transforming growth factor beta-1 proprotein (−) | P01137 | TGFB1 | 7 | 19.7 | 0.78 |
| 57 | Tropomyosin alpha-4 chain (−) | P67936 | TPM4 | 5 | 28.2 | 0.80 |
| 58 | Tubulin alpha-1A chain (+) | P68362 | TUBA1A | 4 | 28.6 | 1.35 |
| 59 | Vasodilator-stimulated phosphoprotein (+) | P50552 | VASP | 2 | 6.3 | 1.31 |