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Impact of Cholecystectomy on Gastric Mucosal c-MYC and h-TERT Expression; A Potential Link to Gastric Cancer Development Cover

Impact of Cholecystectomy on Gastric Mucosal c-MYC and h-TERT Expression; A Potential Link to Gastric Cancer Development

Open Access
|May 2026

Figures & Tables

Figure 1.

Relative expressions of c-MYC and hTERT mRNA

Demographic Characteristics of Participants by Group

Gastric CancerCholecystectomyControl
Mean Age65,2 ± 10,160,5 ± 9,259,9 ± 13,5
GenderFemale n (%)16 (%50)22 (%64)23 (%67)
Male n (%)16 (%50)12 (%36)11 (%33)

Comparison of H_ pylori Infection and Intestinal Metaplasia Across Study Groups

Groupsp-value
Control (n=34)Cholecystectomy (CK) (n=34)Gastric Cancer (CA) (CA) (n=32)

H.pylori
Negative15 (%44,1)17 (%50,0)13 (%40,6)0,740
Positive19 (%55,9)17 (%50,0)19 (%59,4)

Intestinal Metaplasia
Negative20 (%58,8)26 (%76,5)-0,120
Positive14 (%41,2)8 (%23,5)

Specific Primer Sequences Used for mRNA Expression Analysis of c-MYC, hTERT, and β-Actin (5′→3′)

ACTB
  Primer setsACCAGGGCGTGATGGT (Forward) CGTCCCAGTTGGTGACG (Reverse)
c-MYC
  Primer setsCCTGGTGCTCCATGAGG (Forward) CCAGACTCTGACCTTTTGCC (Reverse)
hTERT
  Primer setsGCCGATTGTGAACATGGAC (Forward) CGTAGTTGAGCACGCTGAA (Reverse)
Language: English
Page range: 57 - 64
Published on: May 14, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2026 E Kasap, S Sabah Özcan, L Elmas, F Seher Ozalp Ates, M Korkmaz, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.