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Secretory Breast Carcinoma in A Six-Year-Old Girl: Case Report With Genetic Insights and Therapeutic Implications Cover

Secretory Breast Carcinoma in A Six-Year-Old Girl: Case Report With Genetic Insights and Therapeutic Implications

Balkan Journal of Medical Genetics
Volume 28 (2025): Issue 2 (December 2025)
By: ,  ,  ,  ,  ,  ,  ,   and    
Open Access
|May 2026
Figures & tables

Figures & Tables

Figure 1.

Gross, histopathological, and immunohistochemical features of secretory breast carcinoma in a six-year-old girl: (a) Gross specimen of the excised tumor, approximately 10 × 10 mm, well-circumscribed and lobulated; (b) Lobular tumor architecture with a clearly visible pseudocapsule (HE, ×25); (c) Microcystic, cribriform, and tubular growth patterns with intraluminal secretory material (HE, ×100); (d) High mitotic activity, reflecting the proliferative potential of the tumor (HE, ×1000); (e) Focal membranous/cytoplasmic CD117 positivity (×200); (f) Ki-67 nuclear positivity in approximately 20% of tumor cells (×200); (g) Rare scattered p63-positive nuclei (<5% of tumor cells) (×200); (h) Strong and diffuse nuclear/cytoplasmic S-100 immunopositivity (×100).

Figure 2.

Intraoperative photograph during axillary lymph node dissection performed at six-month follow-up due to two ultrasonographically suspicious nodes (22 × 18 mm and 6 × 2 mm), which were subsequently confirmed to be histologically benign.

Figure 3.

Long-term postoperative follow-up of the patient: (a) Frontal view demonstrating good cosmetic outcome after mastectomy; (b) Slightly angled frontal view, confirming a well-healed scar and symmetrical chest contour.
DOI: https://doi.org/10.2478/bjmg-2025-00019 | Journal eISSN: 2199-5761
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Language: English
Page range: 101 - 106
Published on: May 14, 2026
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Secretory breast carcinoma,
Pediatric breast cancer,
ETV6-NTRK3 fusion,
Targeted therapy,
TRK inhibitors,
Case report,
Precision oncology
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2026 A Vlahović, S Nikolić, S M Djuričić, D Dunđerović, N Ilić, A Sarajlija, M Denčić Fekete, A Cvetinović, M Vasić, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 28 (2025): Issue 2 (December 2025)
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