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PON1 (Paraoxonase 1) Q192R Gene Polymorphism in North Macedonian Population with Confirmed Coronary Artery Disease Cover

PON1 (Paraoxonase 1) Q192R Gene Polymorphism in North Macedonian Population with Confirmed Coronary Artery Disease

Open Access
|May 2026

Figures & Tables

Biochemical parameters statistical relevance between CAD and non-CAD

CADnonCADAll patientsSample sizeANOVA
Mean (StDev)Mean (StDev)Mean (StDev)(CAD/non -CAD)p
Age64.72(±8.3)61.83(±9.4)63.68(±8.8)106/590.0428
Statins (mg/day)31.42(±17.9)21.95(±17.7)28.03(±18.3)106/590.0013
Glucose7.46(±3.3)6.57(±2.1)7.15(±2.8)103/580.0508
Lp(a)40.21(±50.2)16.51(±15.2)32.19(±43.2)84/430.0031
ApoB0.92(±0.3)0.9(±0.2)0.91(±0.3)101/570.7213
ApoA11.23(±0.2)1.36(±0.3)1.28(±0.2)99/570.001
HDL1.12(±0.3)1.28(±0.3)1.17(±0.3)103/530.0011
LDL1.83(±0.9)1.89(±0.8)1.85(±0,9)99/560.7001
Total Cholesterol3.7(±1.3)3.45(±0.8)3.7(±1.1)103/550.8718
TG1.17(±0.7)1.18(±0.7)1.18(±0.7)97/560.9699
ACT22.7(±16.8)22.29(±8.2)22.56(±14.3)104/580.8622

Association between QQ vs_ QR and non-CAD vs_ stenting

non-CADStentingχ2OR (95% CI)p
QQ20 (E=14.75)17 (E=22.25)4.14320.461[0.216–0.589]0.0418
QR+RR39 (E=44.25)72 (E=66.75)

Profile of the patient group in the study

CADnon-CAD
Gender (Male)80 (72%)31(28%)
Gender (Female)26 (48%)28 (52%)
Nationality (Macedonian)87 (66%)45 (34%)
Nationality (Albanians)19 (58%)14 (42%)
Smoking31 (70%)13 (30%)
Stent36 (100%)0 (0%)
Restenosis46 (100%)0 (0%)
Diabetes36 (72%)14 (28%)
Q192R(QQ)22 (52%)20 (48%)
Q192R(QR)81 (67%)39 (33%)
Q192R(RR)2 (100%)0 (0%)

Statistical relevance of the biochemical parameters between QQ and QR+RR

QQQRQR+RRAll patientsSample sizeANOVA
Mean (StDev)Mean (StDev)Mean (StDev)Mean (StDev)QQ/QR/QR+RRp
Age62.73(±10.2)64.18(±8.2)64.2(±8.2)63.92(±8.2)45/120/1220.2756
Statins28.67(±19.7)28.29(±17.7)28 (±17.8)27.97(±18.2)45/120/1220.9437
Glucose7.71(±3.3)6.93(±2.6)6.95(±2.6)7.14(±2.8)41/117/1200.1375
Lp(a)32.81(±43)30.73(±41.2)31.98(±43.4)32.19(±43.2)32/92/950.9260
ApoB0.9(±0.3)0.89(±0.3)0.9(±0.3)0.91(±0.3)40/115/1180.2952
ApoA11.3(±0.3)1.27(±0.2)1.27(±0.2)1.28(±0.2)40/113/1160.5834
HDL1.23(±0.3)1.16(±0.3)1.16(±0.3)1.17(±0.3)38/115/1180.1731
LDL2(±0.8)1.81(±0.9)1.8(±0.9)1.85(±0.9)40/112/1150.2129
Total Chol.3.97(±1)3.62(±1.1)3.62(±1.1)3.71(±1.1)41/114/1170.0729
TG1.2(±0.7)1.16(±0.7)1.17(±0.7)1.18(±0.7)39/112/1140.7881
ACT20.9(±8.1)23.1(±16)23.12(±15.9)22.56(±14.3)41/118/1210.3934

Association between QQ vs_ QR and non-CAD vs_ CAD

non-CADCADχ2OR (95% CI)p
QQ20 (E=15.02)22 (E=26.98)3.45080.511[0.25–0.595]0.0632
QR+RR39 (E=43.98)83 (E=79.02)
Language: English
Page range: 49 - 56
Published on: May 14, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2026 K Krsteva Jakimovska, M Vavlukis, A Eftimov, S Topuzovska, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.