Figure 1.
Clinical periodontal parameters of the study participants by sex
| Females (n = 5) mean ± SD | Males (n = 5) mean ± SD | p-value | |
|---|---|---|---|
| Age | 48.4 ± 4.2 | 51.2 ± 9.9 | 1.000 |
| FMPS (%) | 53.2 ± 22.6 | 76.2 ± 18.8 | 0.095 |
| FMBS (%) | 50.2 ± 14.0 | 51.6 ± 18.0 | 0.917 |
| PPD ≤ 3 mm (%) | 33.2 ± 4.4 | 33.4 ± 8.9 | 1.000 |
| PPD 4–5 mm (%) | 52.0 ± 3.5 | 55.0 ± 7.0 | 0.599 |
| PPD > 5 mm (%) | 14.8 ± 5.9 | 11.6 ± 4.8 | 0.463 |
| CAL 1–2 mm (%) | 26.2 ± 8.3 | 22.8 ± 7.7 | 0.402 |
| CAL 3–4 mm (%) | 36.6 ± 3.3 | 40.4 ± 12.0 | 0.674 |
| CAL ≥ 5 mm (%) | 37.2 ± 10.8 | 36.8 ± 13.4 | 1.000 |
| BoP (%) | 50.4 ± 15.4 | 40.6 ± 17.0 | 0.463 |
| BL/Age | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.222 |
| Teeth lost (n) | 2.0 ± 3.4 | 3.0 ± 1.0 | 0.139 |
Differential gene expression between male and female patients with severe periodontitis
| Gene | Females (mean ± SD) | Males (mean ± SD) | log2FC (F/M) | Cohen’s d (F−M) | p-value | FDR |
|---|---|---|---|---|---|---|
| AREG | 30.77 ± 10.04 | 48.90 ± 10.94 | –0.67 | –1.73 | 0.030 | 0.150 |
| NOD2 | 65.24 ± 25.36 | 32.63 ± 22.35 | 1.00 | 1.36 | 0.030 | 0.150 |
| MEF2A | 92.79 ± 48.83 | 47.40 ± 15.99 | 0.97 | 1.25 | 0.050 | 0.150 |
| IL8 | 6774.52 ± 3034.30 | 12004.66 ± 7485.36 | –0.83 | –0.92 | 0.060 | 0.150 |
| MX1 | 294.04 ± 813.10 | 67.84 ± 25.54 | 2.12 | 0.39 | 0.080 | 0.157 |
| STAT1 | 93.86 ± 84.76 | 52.33 ± 12.30 | 0.84 | 0.69 | 0.100 | 0.157 |
| TNFSF14 | 19.79 ± 13.16 | 31.79 ± 8.72 | –0.68 | –1.07 | 0.110 | 0.157 |
| FLT1 | 16.46 ± 12.13 | 31.20 ± 18.48 | –0.92 | –0.94 | 0.150 | 0.160 |
| IFI44 | 23.26 ± 202.93 | 6.14 ± 3.47 | 1.92 | 0.12 | 0.160 | 0.160 |
| IFIT1 | 86.51 ± 478.37 | 25.99 ± 19.12 | 1.73 | 0.18 | 0.160 | 0.160 |