Figure 1:
Heatmap of the clinical, molecular and treatment response data in a cohort of 55 pediatric patients with B-ALL a white blood cell count; b copy number alterations; c prednisolone good response; d prednisolone poor response; e induction failure
Table 1.
Clinically relevant alterations in the patients with relapse
| Copy number alterations | Single nucleotide variants | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No.a | Sample type | Aneuploidy/Hybrid transcript | TP53 | EBF1 | CDKN2A/2B | PAX5 | ETV6 | CREBBP | NRAS | MSH2 | FLT3 |
| 4 | Dg | high-hyperdiploidy | -/- | -/- | -/- | -/- | -/- | - | - | - | + |
| Relapse | high-hyperdiploidy | -/- | -/- | -/- | -/- | -/- | + | + | - | - | |
| 10 | Dg | high-hyperdiploidy | -/- | -/dup | -/- | -/- | -/- | + | - | - | - |
| Relapse | high-hyperdiploidy | -/del | -/dup | -/- | -/- | -/- | + | - | - | - | |
| 32 | Dg | BCR::ABL1 | -/- | -/- | -/delb | -/delb | -/- | - | - | - | - |
| Relapse | BCR::ABL1 | -/- | -/- | -/- | -/- | -/- | + | - | + | - | |
| 35 | Dg | -/- | -/- | -/- | -/- | -/- | +c | + | - | - | |
| Relapse | -/- | -/- | -/del | -/- | -/- | +c | - | - | - | ||
| 36 | Dg | -/del | -/del | -/- | -/- | -/del | - | - | - | - | |
| Relapse | -/del | -/del | -/- | -/- | -/del | - | - | - | - | ||
1a Patient identification number from Figure 1