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CREBBP is a Major Prognostic Biomarker for Relapse in Childhood B-cell Acute Lymphoblastic Leukemia: A National Study of Unselected Cohort Cover

CREBBP is a Major Prognostic Biomarker for Relapse in Childhood B-cell Acute Lymphoblastic Leukemia: A National Study of Unselected Cohort

Balkan Journal of Medical Genetics
Volume 27 (2024): Issue 2 (December 2024)
By: E Krstevska Bozhinovikj,  N Matevska-Geshkovska,  M Staninova Stojovska,  E Gjorgievska,  A Jovanovska,  S Kocheva and  A Dimovski  
Open Access
|Mar 2025

Figures & Tables

Figure 1:

Heatmap of the clinical, molecular and treatment response data in a cohort of 55 pediatric patients with B-ALL a white blood cell count; b copy number alterations; c prednisolone good response; d prednisolone poor response; e induction failure
Heatmap of the clinical, molecular and treatment response data in a cohort of 55 pediatric patients with B-ALL a white blood cell count; b copy number alterations; c prednisolone good response; d prednisolone poor response; e induction failure

Clinically relevant alterations in the patients with relapse

Copy number alterationsSingle nucleotide variants
No.aSample typeAneuploidy/Hybrid transcriptTP53EBF1CDKN2A/2BPAX5ETV6CREBBPNRASMSH2FLT3
4Dghigh-hyperdiploidy-/--/--/--/--/----+
Relapsehigh-hyperdiploidy-/--/--/--/--/-++--
10Dghigh-hyperdiploidy-/--/dup-/--/--/-+---
Relapsehigh-hyperdiploidy-/del-/dup-/--/--/-+---
32DgBCR::ABL1-/--/--/delb-/delb-/-----
RelapseBCR::ABL1-/--/--/--/--/-+-+-
35Dg -/--/--/--/--/-+c+--
Relapse -/--/--/del-/--/-+c---
36Dg -/del-/del-/--/--/del----
Relapse -/del-/del-/--/--/del----
DOI: https://doi.org/10.2478/bjmg-2024-0020 | Journal eISSN: 2199-5761
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Language: English
Page range: 5 - 12
Published on: Mar 6, 2025
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
acute lymphoblastic leukemia,
relapse,
molecular biomarkers,
CREBBP
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2025 E Krstevska Bozhinovikj, N Matevska-Geshkovska, M Staninova Stojovska, E Gjorgievska, A Jovanovska, S Kocheva, A Dimovski, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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