Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
Figure 7.
Figure 8.
Calculated half-lives of the glycosidic bond connecting RNA ribose and nucleobase, at pH 7_ Parameters taken from Stockbridge et al_ (18)_
| Temperature | Rate constant, k | Half-life | |
|---|---|---|---|
| Days | Years | ||
| 25°C | 3.7 × 10−12 s−1 | 2,168,253 | 5,936 |
| 80°C | 5.82 × 10−9 s−1 | 1379.3 | 3.78 |
| 85°C | 1.02 × 10−8 s−1 | 790.2 | 2.16 |
| 90°C | 1.75 × 10−8 s−1 | 459.7 | 1.26 |
| 95°C | 2.96 × 10−8 s−1 | 271.4 | 0.74 |
| 100°C | 1.40 × 10−7 s−1 | 162.5 | 0.44 |